Self-assessed neurological disturbances after surgical removal of impacted lower third molar: a pragmatic prospective study on 423 surgical extractions in 247 consecutive patients

OBJECTIVES: The aim of this study was to assess the combined role of current radiographic risk indicators and patient age in predicting lower lip sensitivity disturbances after surgical removal of impacted lower third molars. The question was which combinations indicate low or high risk. MATERIALS AND METHODS: A prospective study was implemented involving 247 consecutive outpatients who underwent 423 surgical extractions. The predictor variables were patient age and risk indicators observed on panoramic radiographs. The outcome variable was the incidence of self-assessed lip sensitivity alterations. The extractions were subdivided into four groups according to the predictors. RESULTS: Two hundred forty-five teeth were extracted in patients younger than 25 years and 178 in patients 25 years old or older; radiographic risk indicators were associated with 226 out of 423 teeth (53.43%). No permanent neurological damage was observed. Transient lip sensitivity alterations were observed in five cases (1.18%; 95% confidence interval\u2009=\u20090.4 to 2.7%), all in the older group with radiographic risk indicators. CONCLUSIONS: The data indicate a low overall incidence of transient lip sensitivity impairment that occurred only in the presence of radiographic risk indicators in patients aged 65\u200925 years. CLINICAL RELEVANCE: Informed consent should include the possibility of inferior alveolar nerve injury in mature patients with radiographic risk indicators. Prophylactic removal of impacted teeth with radiographic signs of risk may be indicated when the patient is not yet aged 25 years

Production and detection of doubly charmed tetraquarks

The feasibility of tetraquark detection is studied. For the cc\bar{u}\bar{d} tetraquark we show that in present (SELEX, Tevatron, RHIC) and future facilities (LHCb, ALICE) the production rate is promising and we propose some detectable decay channels.Comment: 6 pages, 5 figure

Double parton distributions in the leading logarithm approximation of perturbative QCD

Recent CDF measurements of the inclusive cross section for a double parton scattering attach a great importance to any theoretical calculations of two-particle distribution functions. Using a parton interpretation of the leading logarithm diagrams of perturbative QCD theory, generalized Lipatov-Altarelli-Parisi-Dokshitzer equations for the two-parton distributions are re-obtained. The solutions of these equations are not at all the product of two single-parton distributions what is usually applied to the current analysis as ansatz.Comment: 8 pages, LaTe

Immediate postextraction screw-retained partial and full-arch rehabilitation: A 3-year follow-up retrospective clinical study

The aim of this study was to document the performance of a novel technique (OnlyOne), involving immediate restoration of postextraction implants supporting a partial or full-arch restoration. A retrospective analysis of patients with at least 3 years of follow-up was performed. Implants were tilted mesiodistally and vestibulopalatally according to the available bone. Prosthetically guided definitive abutments were connected at surgery and never disconnected. Anorganic bovine bone grafting was done to preserve the buccal bone and the ridge contour. Patients received a screw-retained provisional prosthesis within 24 hours of surgery and a final screw-retained prosthesis within 1 year. Prostheses emerged from natural soft tissue. Clinical and radiographic evaluation was routinely performed. A total of 70 patients received 153 implants in fresh extraction sockets. The mean follow-up was 38.0 \ub1 3.0 months (range 36 to 51 months). One implant failed at the 3-year follow-up. Implant survival was 99.3%. Marginal bone level change averaged -0.68 \ub1 1.2 mm at the last radiographic control. Immediate placement and restoration of implants designed for high primary stability with a definitive abutment placed at surgery and final screw-retained prosthesis with no artificial gingiva is a viable procedure with excellent medium-term outcomes

APPLICAZIONE DI TECNICHE NUMERICHE ALL\u2019INTERAZIONE CINEMATICA PALO-TERRENO

Nella nota vengono presentati i risultati di modellazioni numeriche di interazione cinematica palo-terreno, eseguite sia su modelli teorici che per un esempio reale di terreni stratificati altamente deformabili. Nello studio sono stati utilizzati due diversi programmi commerciali per applicazioni di ingegneria geotecnica. Nel primo caso \ue8 stata condotta una modellazione agli elementi finiti 2D e si sono effettuati dei confronti con altri studi di letteratura. Nel secondo caso \ue8 stato invece impiegato un codice alle differenze finite 3D, adottando nelle analisi lineari anche uno smorzamento numerico non convenzionale. Si sono pertanto sviluppate le procedure di validazione e calibrazione di questo tipo di modellazione per poter procedere in futuro con analisi pi\uf9 avanzate

Soft tissue augmentation applying a collagenated porcine dermal matrix during second stage surgery: A prospective multicenter case series

BACKGROUND The achievement and preservation of an adequate amount of soft tissue around implants is a critical factor for the prognosis of the treatment. PURPOSE To evaluate the effectiveness of a porcine dermal matrix applied during second stage implant surgery for horizontal soft tissue augmentation and preservation of dimensional stability. MATERIALS AND METHODS Twenty patients (mean age 50.2 ± 11.9 [SD] years) candidate to implant therapy and requiring soft tissue augmentation were recruited in four centers. Augmentation was performed in 24 cases. A porcine dermal matrix was placed into a buccal split-thickness pouch during uncovering surgery. Silicone impressions were taken before surgery (T0), 2 weeks later at suture removal (T2), 6 months (T3), and 24 months (T4) post augmentation. Dimensional changes of soft tissue were evaluated using superimposition of digitalized study casts. RESULTS Nineteen patients (23 implants) could be evaluated at 6 months and 13 patients (17 implants) at 24 months. After 6-month follow-up, there was a significant dimensional gain respect to baseline, averaging 0.83 ± 0.64 mm (P 0.5 mm in 65.2% and 64.7% of the cases, respectively. Soft tissue shrinkage averaged 34.2% ± 77.0% from T2 to T3 (P < .01) and did not change thereafter (P = .39). Shrinkage was more consistent in the posterior mandible than in the maxilla, but not significantly (P = .23 at 6-month and .36 at 24-month). No adverse events occurred. CONCLUSION Within the limitations of this prospective case series, the use of a porcine dermal matrix may provide consistent soft tissue augmentation that maintains up to 24-month follow-up, although graft shrinkage may occur in the first 6 months, depending on the location of surgery

VBL: Virtual Biophysics Lab

VBL (Virtual Biophysics Lab) is a computational project to develop a basic numerical model of tumor spheroids. This paper is a status report that describes the structure of the code that implements the model, and the progress made up to February 2008, and also some recent results in modeling the effects of radiations on cells in a bioreactor

A quantitative study on the growth variability of tumour cell clones in vitro

Objectives: In this study, we quantify the growth variability of tumour cell clones from a human leukemia cell line. Materials and methods: We have used microplate spectrophotometry to measure the growth kinetics of hundreds of individual cell clones from the Molt3 cell line. The growth rate of each clonal population has been estimated by fitting experimental data with the logistic equation. Results: The growth rates were observed to vary among different clones. Up to six clones with a growth rate above or below the mean growth rate of the parent population were further cloned and the growth rates of their offsprings were measured. The distribution of the growth rates of the subclones did not significantly differ from that of the parent population thus suggesting that growth variability has an epigenetic origin. To explain the observed distributions of clonal growth rates we have developed a probabilistic model assuming that the fluctuations in the number of mitochondria through successive cell cycles are the leading cause of growth variability. For fitting purposes, we have estimated experimentally by flow cytometry the maximum average number of mitochondria in Molt3 cells. The model fits nicely the observed distributions of growth rates, however, cells in which the mitochondria were rendered non functional (rho-0 cells) showed only a 30% reduction in the clonal growth variability with respect to normal cells. Conclusions: A tumor cell population is a dynamic ensemble of clones with highly variable growth rate. At least part of this variability is due to fluctuations in the number of mitochondria.Comment: 31 pages, 5 figure

Same-sign W pair production as a probe of double parton scattering at the LHC

We study the production of same-sign W boson pairs at the LHC in double parton interactions. Compared with simple factorised double parton distributions (dPDFs), we show that the recently developed dPDFs, GS09, lead to non-trivial kinematic correlations between the W bosons. A numerical study of the prospects for observing this process using same-sign dilepton signatures, including same-sign WWjj, di-boson and heavy flavour backgrounds, at 14 TeV centre-of-mass energy is then performed. It is shown that a small excess of same-sign dilepton events from double parton scattering over a background dominated by single scattering WZ(gamma*) production could be observed at the LHC.Comment: 14 pages, 8 figures. Added references, slight changes in the text

Simvastatin and its impact on healing of craniofacial bone and cartilage: A systematic review

Aims and objectives: Many bone regeneration techniques have been introduced in dentistry in order to address lacking of bone tissue. Besides autogenous bone, considered the gold standard, many biomaterials have been involved, such as bone substitutes, barrier membranes, autologous and recombinant growth factors, stem cells and, lately, osteo-promotive pharmacological compounds, such as BMPs, teriparatide, statins, and others. Preclinical and clinical studies, systematic reviews and meta-analyses have investigated the potential of simvastatin in enhancing bone formation. This review aimed at assessing the relevance of simvastatin in bone regeneration, focusing on clinical and histological outcomes in oral surgery. Methodology: The PICO question was \u201cIs the adjunctive use of simvastatin beneficial respect to control for bone regeneration in dentistry?\u201d An electronic search was performed on MEDLINE, Scopus, Cochrane Central Register of Controlled Trials (CENTRAL) using a combination of keywords. A hand search was undertaken on seven oral surgery Journals: Previous systematic reviews were considered for further potential eligible studies. No limitation of language and publication year was placed. Both animal and clinical comparative studies were considered. After inclusion, data on methodology, efficacy and safety were extracted. Included studies underwent risk of bias assessment. Results: One randomized clinical study and 23 studies on animal models (rats, pigs, dogs, rabbits) were included. Simvastatin was tested in different oral applications, such as: periodontal disease, distraction osteogenesis, temporomandibular joint disease, socket preservation, orthodontics. In the range 0.5-1mg and 2.2-2.5mg simvastatin was associated with higher bone formation rate and decreased osteoclastic activity as compared to control. Immunohistochemistry revealed the increased activity of TRAP, MMP-1 and BMP and decreased activity of RANKL when using simvastatin. The outcomes were unrelated to the administration route (local or systemic). Conclusion: This review provided a detailed insight into the osteopromotive effects of simvastatin through clinical, histological and immunohistochemical markers associated with bone regeneration