Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function

The time-keeping properties bestowed by oscillatory behavior on functional rhythms represent an evolutionarily conserved trait in living systems. Mitochondrial networks function as timekeepers maximizing energetic output while tuning reactive oxygen species (ROS) within physiological levels compatible with signaling. In this work, we explore the potential for timekeeping functions dependent on mitochondrial dynamics with the validated two-compartment mitochondrial energetic-redox (ME-R) computational model, that takes into account (a) four main redox couples [NADH, NADPH, GSH, Trx(SH)2], (b) scavenging systems (glutathione, thioredoxin, SOD, catalase) distributed in matrix and extra-matrix compartments, and (c) transport of ROS species between them. Herein, we describe that the ME-R model can exhibit highly complex oscillatory dynamics in energetic/redox variables and ROS species, consisting of at least five frequencies with modulated amplitudes and period according to power spectral analysis. By stability analysis we describe that the extent of steady state—as against complex oscillatory behavior—was dependent upon the abundance of Mn and Cu, Zn SODs, and their interplay with ROS production in the respiratory chain. Large parametric regions corresponding to oscillatory dynamics of increasingly complex waveforms were obtained at low Cu, Zn SOD concentration as a function of Mn SOD. This oscillatory domain was greatly reduced at higher levels of Cu, Zn SOD. Interestingly, the realm of complex oscillations was located at the edge between normal and pathological mitochondrial energetic behavior, and was characterized by oxidative stress. We conclude that complex oscillatory dynamics could represent a frequency- and amplitude-modulated H2O2 signaling mechanism that arises under intense oxidative stress. By modulating SOD, cells could have evolved an adaptive compromise between relative constancy and the flexibility required under stressful redox/energetic conditions.Fil: Kembro, Jackelyn Melissa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; ArgentinaFil: Cortassa, Sonia del Carmen. University Johns Hopkins; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Aon, Miguel A.. University Johns Hopkins; Estados Unido

Analysis of noise-induced temporal correlations in neuronal spike sequences

This is a copy of the author 's final draft version of an article published in the journal European physical journal. Special topics. The final publication is available at Springer via http://dx.doi.org/10.1140/epjst/e2016-60024-6We investigate temporal correlations in sequences of noise-induced neuronal spikes, using a symbolic method of time-series analysis. We focus on the sequence of time-intervals between consecutive spikes (inter-spike-intervals, ISIs). The analysis method, known as ordinal analysis, transforms the ISI sequence into a sequence of ordinal patterns (OPs), which are defined in terms of the relative ordering of consecutive ISIs. The ISI sequences are obtained from extensive simulations of two neuron models (FitzHugh-Nagumo, FHN, and integrate-and-fire, IF), with correlated noise. We find that, as the noise strength increases, temporal order gradually emerges, revealed by the existence of more frequent ordinal patterns in the ISI sequence. While in the FHN model the most frequent OP depends on the noise strength, in the IF model it is independent of the noise strength. In both models, the correlation time of the noise affects the OP probabilities but does not modify the most probable pattern.Peer ReviewedPostprint (author's final draft

The Minimal Overlap Rule: Restrictions on Mergers for Creditors' Consensus

This paper proposes a notion of partial Additivity in bankruptcy, -Additivity. We show that this property, together with Anonymity and Continuity, identifies the Minimal Overlap rule, introduced by O'Neill (1982).Bankruptcy Problems; Additivity; Minimal Overlap Rule

Optimized Design of Hot Water Storage in Solar Thermal Cooling Facilities

Solar thermal installations can provide a significant contribution to the energy needs of cooling demand of single family buildings. Unfortunately oversizing facility elements is not uncommon. Most of the design flaws concern collector field or auxiliary elements, such as backup boilers or electric resistances inside storage devices. This leads to lower than expected facility COP and SCOP, but also higher cost. Customer dissatisfaction is the result. This paper presents a numerical model of the multiple purpose solar thermal facility installed at Universidad Carlos III de Madrid (UC3M) using the TRNSYS® tool. The solar cooling facility (http://termica.uc3m.es/solar.htm) is completely monitored for its performance characterization in the production of AC, DHW and heating. Operational data for various summer seasons have been recorded, simultaneously with 7 meteorological variables. The experimental facility includes a single effect BrLi absorption chiller working at part load under summer season. TRNSYS is a completely feasible platform for simulating solar facilities and is commonly used by researchers and planners, for its simplicity and ease manipulation. This simulation tool contains general solar cooling elements found in most experimental facilities and has been kept as simple as possible. The model developed aims at analyzing facility elements in order to resize collector field and storage volumes. Furthermore it allows studying different configurations of the facility and the control schemes. These configurations include different hot water storage capacities within the facility allowing comparing with the facility without any kind of storage excepting its own thermal inertia. The simulation has been validated with instantaneous and seasonal experimental data for different summer seasons including 2003, 2004 and 2005. Simulation results show that there is a hot storage tank capacity that optimizes the facility in terms of COP, SCOP and total cold produced. Even with no storage at all, the facility still improves its behavior from current operating conditions. Simulation and experimental results are compared and an optimum configuration of the facility is proposed.Universidad Carlos III de Madrid - ITEA Research GroupPublicad

Spectral averaging techniques for Jacobi matrices

Spectral averaging techniques for one-dimensional discrete Schroedinger operators are revisited and extended. In particular, simultaneous averaging over several parameters is discussed. Special focus is put on proving lower bounds on the density of the averaged spectral measures. These Wegner type estimates are used to analyze stability properties for the spectral types of Jacobi matrices under local perturbations

Simulation of an absorption based solar cooling facility using a geothermal sink for heat rejection

An important issue of solar cooling facilities based on absorption cycles and sometimes not given the necessary attention is the recooling process of the absorber and condenser. This is critical in the overall behaviour of the facility because the condensation and absorption temperatures will affect the COP and cooling capacity of the chiller. Most of the time the recooling process is made by using a wet cooling tower in a closed loop through the absorber and condenser. The use of a wet cooling tower gives good results in terms of cooling capacity and COP, but presents some health risk, like legionella, and its use is restricted to the industrial sector and places where water scarcity is not present. This paper presents the modification of the already validated TRNSYS simulation of a solar cooling facility, implementing a geothermal heat sink instead of the wet cooling tower in order to dissipate the heat generated internally in the absorption chiller. Simulation results shows that a geothermal heat sink composed of 6 boreholes of 100 meters of depth should be sufficient in order to substitute the wet cooling tower, for a typical Spanish single family dwelling.Universidad Carlos III de Madrid - ITEA Research GroupPublicad

Deployment of Digital Video and Audio Over Electrical SCADA Networks

With the arrival of new hardware and software technologies, supervisory control and data acquisition human-machine interfaces (SCADA/HMI), usually text-based, can now benefit from the advantages the inclusion of multimedia information brings. However, due to the special requirements imposed by such systems, integrating audio and video data into the SCADA interfaces is not a trivial task. In this document we analyze those special characteristics and propose solutions so this integration is possible in power systems communication.Ministerio de Ciencia y Tecnología TIC2000-0367-P4-0

Conclusiones

El tema general que aglutina los trabajos presentados en este volumen pobreza, exclusión social y discriminación étnico-racial en América Latina y el Caribe ha sido abordado por los autores en sus múltiples interrelaciones, destacándose en todos el rol de la discriminación étnico-racial en los procesos de producción y reproducción de pobreza. De tal manera, los temas específicos tratados, a saber, discriminación laboral, género y familia, cultura e identidad, implicaciones sociales y políticas, más que un diagnóstico de la problemática en la región, han dado cuenta de las múltiples interrelaciones existentes entre esos fenómenos, y de las diversas aristas que ellos suponen para la investigación y transformación social. Los retos que quedan planteados para la continuidad en el estudio y discusión sobre los temas de pobreza, exclusión social y discriminación étnico-racial en América Latina y el Caribe pueden resumirse en los siguientes: desarrollo de estudios comparativos en la región; logro de mayor vínculo e incidencia en la esfera de la toma de decisiones; profundización en el análisis de las diversas experiencias de desarrollo en la región y de los impactos específicos de las políticas y programas sociales; y consideración de los criterios y propuestas de los actores sociales involucrados, así como de la sociedad civil

Redefining monetary policy rules: A threshold approach

In this paper, we try to analyse the extent to which a redefinition of the monetary policy rule would help to avoid the zero-lower bound, as well as to explore the conditions needed to avoid that constraint. To that aim, we estimate the threshold values of the key variables of the policy rule: the inflation gap and the output gap. The threshold model allows us to know which are the turning points from which the relationship between the key variables and the interest rate revert. In the Eurozone countries, we have found that the inflation gap always contributes to increasing the nominal interest rate. On the contrary, the output gap works differently when it reaches values above or below the threshold value, which would favour the reduction of the interest rates towards the zero levelSpanish Ministry of Economy, Industry and Competitiveness through the project ECO2015-65826-