Relationship between Levels of Brain-Derived Neurotrophic Factor and Metabolic Parameters in Patients with Type 2 Diabetes Mellitus

Background and Aim. Studies have suggested that brain-derived neurotrophic factor (BDNF) plays a role in glucose and lipid metabolism and inflammation. The aim of this study was to evaluate the relationship between serum BDNF levels and various metabolic parameters and inflammatory markers in patients with type 2 diabetes mellitus (T2DM). Materials and Methods. The study included 88 T2DM patients and 33 healthy controls. Fasting blood samples were obtained from the patients and the control group. The serum levels of BDNF were measured with an ELISA kit. The current paper introduces a receiver-operating characteristic (ROC) generalization curve to identify cut-off for the BDNF values in type 2 diabetes patients. Results. The serum levels of BDNF were significantly higher in T2DM patients than in the healthy controls (206.81 ± 107.32 pg/mL versus 130.84 ± 59.81 pg/mL; P<0.001). They showed a positive correlation with the homeostasis model assessment of insulin resistance (HOMA-IR) (r=0.28; P<0.05), the triglyceride level (r=0.265; P<0.05), and white blood cell (WBC) count (r=0.35; P<0.001). In logistic regression analysis, age (P<0.05), body mass index (BMI) (P<0.05), C-reactive protein (CRP) (P<0.05), and BDNF (P<0.01) were independently associated with T2DM. In ROC curve analysis, BDNF cut-off was 137. Conclusion. The serum BDNF level was higher in patients with T2DM. The BDNF had a cut-off value of 137. The findings suggest that BDNF may contribute to glucose and lipid metabolism and inflammation

Substituted phthalocyanines and their electropolymerization properties

Biyiklioglu, Zekeriya/0000-0001-5138-214X; AKCAY, Hakki Turker/0000-0002-8502-9608WOS: 000383811300083In this study, new metal-free and metallo-phthalocyanine complexes (Co, TiO) were synthesized using a piperazine-substituted phthalonitrile derivative. All proposed structures were supported by instrumental methods. Electrochemical studies of H-2-Pc, (TiOPc)-O-IV, and (COPc)-Pc-II were examined using cyclic voltammetry (CV) and square-wave voltammetry (SWV) techniques. Voltammetric analyses of phthalocyanines supported the proposed structure of the synthesized complexes. All studied phthalocyanines were oxidatively electropolymerized on the working electrode during the repetitive anodic potential scans. (C) 2016 Elsevier B.V. All rights reserved.Karadeniz Technical UniversityKaradeniz Technical University; Sinop UniversitySinop UniversityThe authors wish to thank Karadeniz Technical University and Sinop University

Preconcentration of trace elements on amberlite XAD-4 resin functionalised with 1,2-bis (o-aminophenylthio) ethane and their determination by FAAS in environmental samples

WOS: 000252247100009The use of chemically modified XAD-4-1,2-bis (o-aminophenylthio) ethane chelating resin for pre-concentrating Cr6+, Mn2+, Fe3+, Co2+, Cu2+, Cd2+, Zn2+, Pb2+, and Ni2+ was studied using flame atomic absorption spectrometry (FAAS) for metal monitoring in environmental samples. Cd2+, Zn2+, Pb2+, and Ni2+ ions were quantitatively recovered at the rate of 96.0%, 101.0%, 101.0%, and 95.0%, respectively (RSD < 5%), from the studied solutions. The procedure is based on the retention of analytes on a short column of 1,2-bis (o-aminophenylthio) ethane-XAD-4 chelating resin from a buffered sample solution and subsequent elution with 1 M HNO3. Various parameters, such as pH, eluent type, and concentration, flow rate of sample solution and matrix interference effect on the retention oft he metal ions have been studied. The optimum pH for the sorption of the above-mentioned metal ions was about 6. The adsorption and batch capacity of adsorbent and loading half time ( t(1/2)) for Ni2+, Zn2+, Cd2+, and Pb2+ were established. The limit of detection was 3.0 mu g L-1 for Pb2+ and Ni2+, 0.6 mu g L-1 for Cd2+, and 0.3 mu g L-1 for Zn2+. The validation of the procedure was carried out by analysis of certified reference materials and standard addition. The proposed enrichment method was applied to environmental samples from Trabzon

New bis 1,3,4-oxadiazole derivatives: syntheses, characterizations, computational studies, and antioxidant activities

WOS: 000450109800007In this study, two new bis oxadiazole derivatives (2a and 2b) were synthesized. The new compounds were characterized by elemental analyses, IR, H-1 NMR, C-13 NMR, and mass spectral studies and were tested for their antioxidant activity. According to the results, it was observed that the synthesized compounds (2a and 2b) had a very high activity in both 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing ability of plasma (FRAP) tests. The approximate geometries of the compounds 2a and 2b were prepared with GaussView5 visualization program. The optimized molecular geometric parameters. vibrational wavenumbers, UV-vis parameters, and HOMO-LUMO simulations were computed using Gaussian 09W program. The computations were performed at 6-3114-14(d,p) basis set using the B3LYP functional in density functional theory (DFT) method. The harmonic vibrational wavenumbers computed in gas phase were scaled with 0.958 (1700-4000 cm(-1)) and 0.983 (0-1700 cm(-1)) for the B3LYP/6-3114-1-G(d,p) level. To calculated the UV-vis spectroscopic parameters with TD-DFT method, the compounds 2a and 2b were optimized in DMF and DMSO solvents using the integral equation formalism polarizable continuum model (IEFPCM) method at the B3LYP/6-311++G(d,p) level. The HOMO, LUMO, and UV-vis analyses were studied to interpret intramolecular charge transfers

Photophysical and photochemical study on the tetra 4-isopropylbenzyloxy substituted phthalocyanines

Yalcin, Izzet/0000-0001-6780-1054; AKCAY, Hakki Turker/0000-0002-8502-9608;WOS: 000413037400107In this study, the novel peripherally tetra 4-isopropylbenzyloxy substituted metal-free (4) zinc(II) (5) and oxotitanium(IV) (6) phthalocyanine complexes were synthesized. Furthermore, the axially 4-isopropylbenzyloxy substituted silicon(IV) phthalocyanine derivative (7) was also synthesized. These novel compounds were characterized by different spectroscopic methods such as FT-IR, H-1 NMR, UV-vis and mass. the spectroscopic, photophysical and photochemical properties including electronic absorption, steady state fluorescence, singlet oxygen generation and photostability were studied in toluene.Karadeniz Techincal University [FHD-2016-5630]This study was supported by Karadeniz Techincal University - Research Funding (Project no FHD-2016-5630)

Impact of Neuro-Behcet Disease Immunoglobulin G on Neuronal Apoptosis

Introduction: Parenchymal neuro-Behcet disease (NBD) is encountered in 5%-15% of Behcet disease (BD) patients and is characterized by inflammation of the brainstem and diencephalon structures. Neuronal apoptosis has been shown to participate in neuronal cell loss. Anti-neuronal antibodies have been identified in NBD patients. However, the pathogenic properties of these antibodies have not been studied

Synthesis, spectra and crystal structure of 2-({[3-(methyl{3-[(2-hydroxybenzylidene)amino]propyl} amino)propyl]imino}methyl)phenol copper(II) complex

A copper(II) complex, [Cu(salenN3], [salenN3H2 = 2-({[3-(methyl{3-[(2-hydroxybenzylidene)amino]propyl}amino)propyl]imino}methyl)phenol] was synthesized and characterized by elemental analyses, FTIR spectra and single crystal X-ray diffraction. The complex crystallizes in the monoclinic space group P21/c with a = 6.877(3), b = 14.109(6), c = 20.106(8) Angstrom, beta = 92.231(14), V = 1949.5(14) Angstrom(3). The salen ligand loses two phenolic hydrogens being a dianion and coordinates to the copper(II) ion as a pentadentate ligand through its two O and three N atoms. The copper(II) complex is five-coordinate, lying between perfect square pyramidal and trigonal-bipyramidal extremes. Use of the structural index parameter (tau) for five coordinate metal complexes indicated that the copper(II) complex exhibits a grater tendency toward trigonal-based-pyramidal geometry (tau &gt; 0.5). The individual molecules in the crystal are held together by C-H(...)pi and (HH)-H-... interactions. The IR and electronic spectra of the complex were discussed in detail. (C) 2003 Elsevier Science B.V. All rights reserved.</p