42 research outputs found

    Traversing probe Patent

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    Flow meter for measuring stagnation pressure in boundary layer around high speed flight vehicl

    WOSMIP II- Workshop on Signatures of Medical and Industrial Isotope Production

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    Medical and industrial fadioisotopes are fundamental tools used in science, medicine and industry with an ever expanding usage in medical practice where their availability is vital. Very sensitive environmental radionuclide monitoring networks have been developed for nuclear-security-related monitoring [particularly Comprehensive Test-Ban-Treaty (CTBT) compliance verification] and are now operational

    Rho GTPases as therapeutic targets in Alzheimer’s disease

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    The progress we have made in understanding Alzheimer’s disease (AD) pathogenesis has led to the identification of several novel pathways and potential therapeutic targets. Rho GTPases have been implicated as critical components in AD pathogenesis, but their various functions and interactions make understanding their complex signaling challenging to study. Recent advancements in both the field of AD and Rho GTPase drug development provide novel tools for the elucidation of Rho GTPases as a viable target for AD. Herein, we summarize the fluctuating activity of Rho GTPases in various stages of AD pathogenesis and in several in vitro and in vivo AD models. We also review the current pharmacological tools such as NSAIDs, RhoA/ROCK, Rac1, and Cdc42 inhibitors used to target Rho GTPases and their use in AD-related studies. Finally, we summarize the behavioral modifications following Rho GTPase modulation in several AD mouse models. As key regulators of several AD-related signals, Rho GTPases have been studied as targets in AD. However, a consensus has yet to be reached regarding the stage at which targeting Rho GTPases would be the most beneficial. The studies discussed herein emphasize the critical role of Rho GTPases and the benefits of their modulation in AD

    Spotlight on dry aging beef: effects of loin type, aging methods, and aging time

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    Dry aging is an old-time process used to produce a high quality beef product marketed to high-end customers. Its most unique quality is the distinctive dry-aged flavor. Dry aging has been accomplished through many protocols over the years, but an optimum protocol has not been adopted. Practitioners of this art are very interested in providing a consistent, quality, safe product. Traditionally, dry aging is done without packaging, which places more emphasis on plant quality control practices to achieve a consistent product. This limits the number of processors that have the ability to produce dry-aged product. Packaging bags with a very high water vapor transmission rate that may simulate traditional dry aging are now available. If the quality from dry aging in these bags is equal to that obtained with the traditional unpackaged method, other processors might consider dry aging because this bag allows for less stringent facility needs and potentially greater yields. Overall, an in-thebag dry-aging system would require fewer controls and still result in decreased weight losses, which would provide a significant yield advantage. Objectives of this research were to determine the combined effects of two different dryaging methods (unpackaged and in the bag), two loin-cut styles (bone-in shell loins and boneless strip loins), and two aging times (21 and 28 days) on flavor, juiciness, tenderness, palatability, development of the unique dry-aged flavor, moisture vapor loss, and microbial growth. An additional objective was to determine effects of vacuum packaging after dry aging on dry-aged flavor stability of steaks
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