2,143 research outputs found
Effective usage of e-resources
There is large quantity of subscribed e-resources which contain quality rich information in most of the technical institute libraries. In spite of advantages in terms of access and search capabilities, they are underused. Systematic plan has to be in place for their promotion of use. While a good ICT infrastructure is a prerequisite, it alone will not do. Proactive strategies are required and these need to be adopted imaginatively. Access to e-resources need to be made easier for both on campus and off campus users. Training will increase the confidence level of the users. Traditional awareness methods include: Personal visits, orientations, brochures, posters and displays. Newer technologies from the Web 2.0 such as RSS alert service, Blogs, Wikis and Face book make the interaction with the library not only interesting but also add more value
Effective usage of e-resources
There is large quantity of subscribed e-resources which contain quality rich information in most of the technical institute libraries. In spite of advantages in terms of access and search capabilities, they are underused. Systematic plan has to be in place for their promotion of use. While a good ICT infrastructure is a prerequisite, it alone will not do. Proactive strategies are required and these need to be adopted imaginatively. Access to e-resources need to be made easier for both on campus and off campus users. Training will increase the confidence level of the users. Traditional awareness methods include: Personal visits, orientations, brochures, posters and displays. Newer technologies from the Web 2.0 such as RSS alert service, Blogs, Wikis and Face book make the interaction with the library not only interesting but also add more value
Characterization of PARIS LaBr(Ce)-NaI(Tl) phoswich detectors upto 22 MeV
In order to understand the performance of the PARIS (Photon Array for the
studies with Radioactive Ion and Stable beams) detector, detailed
characterization of two individual phoswich (LaBr(Ce)-NaI(Tl)) elements has
been carried out. The detector response is investigated over a wide range of
= 0.6 to 22.6 MeV using radioactive sources and employing
reaction at = 163 keV and = 7.2 MeV. The
linearity of energy response of the LaBr(Ce) detector is tested upto 22.6
MeV using three different voltage dividers. The data acquisition system using
CAEN digitizers is set up and optimized to get the best energy and time
resolution. The energy resolution of 2.1% at = 22.6~MeV is
measured for the configuration giving best linearity upto high energy. Time
resolution of the phoswich detector is measured with a Co source after
implementing CFD algorithm for the digitized pulses and is found to be
excellent (FWHM 315~ps). In order to study the effect of count rate on
detectors, the centroid position and width of the = 835~keV peak
were measured upto 220 kHz count rate. The measured efficiency data with
radioactive sources are in good agreement with GEANT4 based simulations. The
total energy spectrum after the add-back of energy signals in phoswich
components is also presented.Comment: Accepted in JINS
Ulocuplumab (BMS-936564 / MDX1338): a fully human anti-CXCR4 antibody induces cell death in chronic lymphocytic leukemia mediated through a reactive oxygen species-dependent pathway.
The CXCR4 receptor (Chemokine C-X-C motif receptor 4) is highly expressed in different hematological malignancies including chronic lymphocytic leukemia (CLL). The CXCR4 ligand (CXCL12) stimulates CXCR4 promoting cell survival and proliferation, and may contribute to the tropism of leukemia cells towards lymphoid tissues. Therefore, strategies targeting CXCR4 may constitute an effective therapeutic approach for CLL. To address that question, we studied the effect of Ulocuplumab (BMS-936564), a fully human IgG4 anti-CXCR4 antibody, using a stroma--CLL cells co-culture model. We found that Ulocuplumab (BMS-936564) inhibited CXCL12 mediated CXCR4 activation-migration of CLL cells at nanomolar concentrations. This effect was comparable to AMD3100 (Plerixafor--Mozobil), a small molecule CXCR4 inhibitor. However, Ulocuplumab (BMS-936564) but not AMD3100 induced apoptosis in CLL at nanomolar concentrations in the presence or absence of stromal cell support. This pro-apoptotic effect was independent of CLL high-risk prognostic markers, was associated with production of reactive oxygen species and did not require caspase activation. Overall, these findings are evidence that Ulocuplumab (BMS-936564) has biological activity in CLL, highlight the relevance of the CXCR4-CXCL12 pathway as a therapeutic target in CLL, and provide biological rationale for ongoing clinical trials in CLL and other hematological malignancies
Beneficial health effects of cumin (Cuminum cyminum) seeds upon incorporation as a potential feed additive in livestock and poultry: A mini-review
Cumin (Cuminum cyminum Linn) is an annual plant of the family Umbelliferae, with its use dating back to ancient times when it was cultivated for its medicinal and culinary potential. Cumin seeds could contain a wide variety of phytochemicals, including alkaloids, coumarins, anthraquinones, flavonoids, glycosides, proteins, resins, saponins, tannins, and steroids. In particular, linoleic acid, one of the unsaturated fatty acids found in abundance in cumin oleoresin, is credited with promoting good health. Many of cumin's purported biological actions in livestock and poultry have been attributed to flavonoids such as apigenin, luteolin, and glycosides. Cumin has several healthful qualities, such as antibacterial, insecticidal, anti-inflammatory, analgesic, antioxidant, anticancer, anti-diabetic, anti-platelet aggregation, hypotensive, bronchodilatory, immunological, anti-amyloidogenic, and anti-osteoporotic properties. Cumin supplementation may improve milk production and reproductive function in dairy cows by altering the feeding pattern of bacteria in the rumen, encouraging the growth of beneficial microbes, or stimulating the secretion of certain digestive enzymes. Because of the low price of cumin seed, it could be concluded that its inclusion in the diet might be beneficial to the commercial poultry industry and reduce the overall cost of egg and meat production. In recent years a rise in cumin's popularity has been seen as a result of the herbal movement spearheaded by naturopaths, yoga gurus, advocates of alternative medicine, and manufacturers of feed additives. Animal nutritionists are exploring the use of cumin for its potential to boost growth, improve nutrient usage efficiency, and reduce greenhouse gas emissions. This mini-review discusses how cumin could be used as a feed ingredient to boost productivity and ensure healthy animal reproduction
A music context for teaching introductory computing
We describe myro.chuck, a Python module for controlling music synthesis, and its applications to teaching introductory computer science. The module was built within the Myro framework using the ChucK programming language, and was used in an introductory computer science course combining robots, graphics and music. The results supported the value of music in engaging students and broadening their view of computer science
Sequence Characterisation and Genotyping of Allelic Variants of Beta Casein Gene Establishes Native Cattle of Ladakh to be a Natural Resource for A2 Milk
Bovine milk is regarded as nature's perfect food due to presence of vital nutrients. However some peptides are generated after proteolytic digestion of β-casein that have opioid properties and may increase the risk of chronic diseases. There are 13 genetic variants of bovine beta-casein; out of these A1 and A2 are the most common in dairy cattle breeds. The A1 and A2 variants differ only at position 67, which is histidine in A1 or proline in A2 milk. Earlier published reports have indicated that A1 β casein could be responsible for several health disorders like diabetes, coronary heart disease etc. while A2 β-casein is generally considered safe for human consumption. In the present study, an effort was made to sequence characterize β casein gene and identify allelic distribution of A1A2 alleles in native cattle of Ladakh region adapted to high altitude and low oxygen condition. The data showed 2 non-synonymous variations in coding region, while 5’UTR was completely conserved. The 3’UTR showed 2 more variations in Ladakhi samples. Further, the genotyping in 85 Ladakhi cattle for A1A2 alleles revealed that in Ladakhi cattle, A2 allele is predominantly present as reported for some of the other Indian breeds. The frequency of A2 allele was 0.90 and frequency of A2A2 genotype was found to be 0.79 in Ladakhi cattle. The present data strongly indicate that local cattle of Ladakh with higher frequency of A2 allele and A2A2 genotype is natural resource for A2 milk. Systematic efforts should be made for long term conservation and genetic improvement of this invaluable genetic resource of Ladakh
Physics Potential of the ICAL detector at the India-based Neutrino Observatory (INO)
The upcoming 50 kt magnetized iron calorimeter (ICAL) detector at the
India-based Neutrino Observatory (INO) is designed to study the atmospheric
neutrinos and antineutrinos separately over a wide range of energies and path
lengths. The primary focus of this experiment is to explore the Earth matter
effects by observing the energy and zenith angle dependence of the atmospheric
neutrinos in the multi-GeV range. This study will be crucial to address some of
the outstanding issues in neutrino oscillation physics, including the
fundamental issue of neutrino mass hierarchy. In this document, we present the
physics potential of the detector as obtained from realistic detector
simulations. We describe the simulation framework, the neutrino interactions in
the detector, and the expected response of the detector to particles traversing
it. The ICAL detector can determine the energy and direction of the muons to a
high precision, and in addition, its sensitivity to multi-GeV hadrons increases
its physics reach substantially. Its charge identification capability, and
hence its ability to distinguish neutrinos from antineutrinos, makes it an
efficient detector for determining the neutrino mass hierarchy. In this report,
we outline the analyses carried out for the determination of neutrino mass
hierarchy and precision measurements of atmospheric neutrino mixing parameters
at ICAL, and give the expected physics reach of the detector with 10 years of
runtime. We also explore the potential of ICAL for probing new physics
scenarios like CPT violation and the presence of magnetic monopoles.Comment: 139 pages, Physics White Paper of the ICAL (INO) Collaboration,
Contents identical with the version published in Pramana - J. Physic
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