Pengaruh Prosedur Reviu, Kompetensi, Dan Jangka Waktu Pelaksanaan Terhadap Kualiats Reviu Laporan Keuangan Pemerintah Daerah Pada Inspektorat SeProvinsi Gorontalo

. This study aims to test the influence of the procedure of the review, the competence of the human resources and the implementation period on the quality of the review of the Financial Statements of the Local Government (LKPD) reported to the Inspectorate in the Province of Gorontalo. The data used in this study are primary data which were collected by using questionnaires as the research instrument and then processed by using SPSS. The data were collected from 92 respondents who are the reviewers and have reviewed the Financial Statements of the Local Government. The method used for this research was quantitative with multiple linear regression analysis. The F-test and t-test were used to test the hypothesis simultaneously and partially. The results show that the variables namely the procedure of the review, the competence of the reviewers and the implementation period altogether affect the quality of the review of the Financial Statements of the Local Government. On the other hand, the procedure of the review in partial has no positive and significant influence on the quality of the review. Thus, it can be concluded that the higher understanding of the procedure of the review, the better quality of the review of the Financial Statements of the Local Government. Then, the competence of the human resources has positive and significant influence on the quality of the review as the higher competence of the human resources of the Inspectorate in the Province of Gorontalo, the better quality of the review of the Financial Statements of the Local Governments. In addition, the implementation period has positive and significant effect on the quality of the review since the better quality of the Financial Statement of the Local Government results from the more effective time and budget allocated for the implementation period done by the staff of the inspectorate in the local government. Keywords : The Procedure of the Review, Competence, Implementation Period, the Quality of the Review

Assessment of optic disc and ganglion cell layer in diabetes mellitus type 2

The purpose of this study was to compare the optic disc parameters, retinal nerve fiber (RNFL), and macular ganglion cell layers between patients with diabetes mellitus (DM) type 2 and healthy controls. In this cross-sectional study, 69 eyes of 69 diabetic patients without diabetic retinopathy and 47 eyes of 47 healthy controls were included. Optic disc parameters (i.e., rim area, disc area, cup to disc ratio, cup volume), RNFL, and macular ganglion cell-inner plexiform layers (GCL+IPL) thickness were measured by means of spectral domain optical coherence tomography. There were not statistically significant differences between the diabetic patients and healthy controls in terms of RNFL thickness (P=.32), rim area (P=.20), disc area (P=.16), cup volume (P=.12), and average macular GCL+IPL thickness (P=.11). Nevertheless, binocular RNFL thickness symmetry percentage (P=.03), average cup to disc ratio (P=.02), and superior-nasal macular GCL+IPL thickness (P=.04) were statistically significantly different in the diabetic and control groups. Diabetic patients without retinopathy have more binocular RNFL thickness asymmetry, higher cup to disc ratio, and thinner sectoral macular GCL+IPL when compared to healthy controls. Our results may support the statement that DM causes inner retinal neurodegenerative changes. © 2017 the Author(s). Published by Wolters Kluwer Health, Inc

ANALISIS KEMAMPUAN SISWA DALAM MENYELESAIKAN SOAL UJIAN NASIONAL MATEMATIKA SMP/MTs BERDASARKAN PERSPEKTIF HIGHER ORDER THINKING SKILLS (HOTS)

This study aims to analyze the ability of mathematics junior high school students in resolving the mathematics HOTS in the national exam (UN).  The methodology used is a descriptive qualitative study. The subject of study is six students of ninth grade consisting of two capable, two people are low capacity, and two others high-profile. Data collection in this research using interviews and test one package the exam every year from 2016-2018, then been validated by the expert, who is elected seven items of about which include an item in 2016, two items of the year 2017, and four items of the year 2018. An instrument used is an enlightenment interview and the national exam in HOTS categorize. The result showed that students low capable with only able to solve the item number-1 and number-4 wich including in HOTS level-4 and 5, and students who are capable of being able to solve problems HOTS have similarities with students who are highly capable of being able to solve the questions number 1, 2, 3, 4, and 7 with HOTS levels 4, 5, and

The urinary cytokine/chemokine signature of renal hyperfiltration in adolescents with type 1 diabetes.

OBJECTIVE: Urinary cytokine/chemokine levels are elevated in adults with type 1 diabetes (T1D) exhibiting renal hyperfiltration. Whether this observation extends to adolescents with T1D remains unknown. Our first objective was to determine the relationship between hyperfiltration and urinary cytokines/chemokines in normotensive, normoalbuminuric adolescents with T1D using GFR(cystatin). Our second aim was to determine the relationship between urine and plasma levels of inflammatory biomarkers, to clarify the origin of these factors. METHODS: Urine and serum cytokines/chemokines (Luminex platform) and GFR(cystatin) were measured in normofiltering (n = 111, T1D-N, GFR<135 ml/min/1.73 m(2)) and hyperfiltering (n = 31, T1D-H, GFR ≥ 135 ml/min/1.73 m(2)) adolescents with T1D (ages 10-16), and in age and sex matched healthy control subjects (HC, n = 59). RESULTS: We noted significant step-wise increases in urinary cytokine/chemokine excretion according to filtration status with highest levels in T1D-H, with parallel trends in serum analyte concentrations. After adjusting for serum glucose at the time of sampling, differences in urinary cytokine excretion were not statistically significant. Only serum IL-2 significantly differed between HC and T1D (p = 0.0076). CONCLUSIONS: Hyperfiltration is associated with increased urinary cytokine/chemokine excretion in T1D adolescents, and parallel trends in serum cytokine concentration. The GFR-associated trends in cytokine excretion may be driven by the effects of ambient hyperglycemia. The relationship between hyperfiltration, glycemia, and variations in serum and urine cytokine expression and their impact on future renal and systemic vascular complications requires further study

Early changes in cardiovascular structure and function in adolescents with type 1 diabetes.

BACKGROUND: Children with type 1 diabetes (T1D) are at higher risk of early adult-onset cardiovascular disease. We assessed cardiovascular structure and function in adolescents with T1D compared with healthy controls and the relationships between peripheral vascular function and myocardial parameters. METHODS AND RESULTS: 199 T1D [14.4 ± 1.6 years, diabetes duration 6.2 (2.0-12.8) years] and 178 controls (14.4 ± 2.1 years) completed endothelial function by flow mediated vasodilatation (FMD), arterial stiffness using pulse wave velocity (PWV) along with M-mode, pulse wave and tissue Doppler, and myocardial deformation echocardiographic imaging. Systolic (113 ± 10 vs. 110 ± 9 mmHg; p = 0.0005) and diastolic (62 ± 7 vs. 58 ± 7 mmHg; p < 0.0001) blood pressures, carotid femoral PWV and endothelial dysfunction measurements were increased in T1D compared with controls. Systolic and diastolic left ventricular dimensions and function by M-mode and pulse wave Doppler assessment were not significantly different. Mitral valve lateral e' (17.6 ± 2.6 vs. 18.6 ± 2.6 cm/s; p < 0.001) and a' (5.4 ± 1.1 vs. 5.9 ± 1.1 cm/s; p < 0.001) myocardial velocities were decreased and E/e' (7.3 ± 1.2 vs. 6.7 ± 1.3; p = 0.0003) increased in T1D. Left ventricular mid circumferential strain (-20.4 ± 2.3 vs. -19.5 ± 1.7 %; p < 0.001) was higher, whereas global longitudinal strain was lower (-19.0 ± 1.9 vs. -19.8 ± 1.5 % p < 0.001) in T1D. CONCLUSIONS: Adolescents with T1D exhibit early changes in blood pressure, peripheral vascular function and left ventricular myocardial deformation indices with a shift from longitudinal to circumferential shortening. Longitudinal follow-up of these changes in ongoing prospective trials may allow detection of those most at risk for cardiovascular abnormalities including hypertension that could preferentially benefit from early therapeutic interventions.Funding was provided by the Juvenile Diabetes Research Foundation- Canadian Clinical Trial Network (JDRF-CCTN), the Canadian Diabetes Association, the Heart and Stroke Foundation of Canada and the Sick Kids Labatt Family Heart Center Innovation fund. Funding was also provided by the British Heart Foundation, Diabetes UK and the Juvenile Diabetes Research Foundation

Towards the first kaonic deuterium measurement with the SIDDHARTA-2 experiment at DAΦNE

The SIDDHARTA-2 experiment is going to perform the longawaited high precision X-ray measurement of kaonic deuterium, obtaining for the first time the values of the shift and the width induced by the strong interaction on the fundamental level. By combining this unprecedented result with the analogous kaonic hydrogen measurement performed by the SIDDHARTA experiment, it will be possible to extract the isospin-dependent antikaon-nucleon scattering lengths, providing direct information on the Quantum Chromodynamics (QCD) in the non-perturbative Chromodynamics (QCD) in the non-perturbative regime in the strangeness sector. This paper describes the SIDDHARTA-2 experiment, presently installed at the DAΦNE collider of Istituto Nazionale di Fisica Nucleare-Laboratori Nazionali di Frascati, and the results obtained during the kaonic helium run, preparatory for the kaonic deuterium data taking campaign planned for 2022

Studies of the linearity and stability of silicon drift detectors for kaonic atoms X-ray spectroscopy

The SIDDHARTA-2 experiment at the DAFNE collider aims to perform precision measurements of kaonic atoms X-ray spectroscopy for the investigation of the antikaon?nucleon strong interaction. To achieve this goal, novel large-area Silicon Drift Detectors (SDDs) have been developed. These devices have special geometry, field configuration, and readout electronics that ensure excellent performance in terms of linearity and stability. The paper presents preliminary results for the linearity determination and stability monitoring of the SDDs system during the measurement of kaonic deuterium carried out in the summer of 2022

Status and perspectives for low energy kaon-nucleon interaction studies at DAΦNE : from SIDDHARTA to SIDDHARTA-2

The study of the antikaon nucleon system at very low energies plays a key role for the understanding of the strong interaction between hadrons in the strangeness sector. The information provided by the low energy kaon- nucleon interaction is accessible through the study of kaonic atoms. The lightest atomic systems, namely the kaonic hydrogen and the kaonic deuterium, provide the isospin dependent kaon-nucleon scattering lengths by measuring the X-rays emitted during their de-excitation to the 1s level. Until now, the most precise kaonic hydrogen measurement and an exploratory measurement of kaonic deuterium were carried out at the DAΦNE collider by the SIDDHARTA collaboration, combining the excellent quality kaon beam delivered by the collider with new experimental techniques, as fast and very precise X-ray detectors, like the Silicon Drift Detectors. Today, the most important experimental information missing in the field of the low-energy antikaon-nucleon interactions is the experimental determination of the hadronic energy shift and width of kaonic deuterium, and will be measured by the new SIDDHARTA-2 experiment, which is installed in DAΦNE and is ready to start the data taking campaign

The SIDDHARTA-2 experiment : preparation for the first kaonic deuterium measurement

The SIDDHARTA-2 experiment aims to perform the first measurement of the kaonic deuterium 2p → 1s x-ray transitions. The apparatus is presently installed at the interaction region of the DAΦNE electron-positron collider at the National Laboratories of Frascati (LNF-INFN), in Italy. Kaonic deuterium and kaonic hydrogen 2p → 1s x-ray transitions measurements, the latter one already performed by the SIDDHARTA collaboration, allow the determination of antikaon-nucleon scattering lengths. A description of the SIDDHARTA-2 apparatus in preparation for the kaonic deuterium measurement is provided in this paper

Trigger rejection factor in the first kaonic helium run with the complete SIDDHARTA-2 setup

The SIDDHARTA-2 experiment aims to perform the first measurement of the kaonic deuterium 2p → 1s x-ray transition energy. Such measurement, together with the measurement of kaonic hydrogen 2p → 1s x-ray energy transition performed by the SIDDHARTA experiment in 2011, allows the determination of kaon proton and kaon neutron scattering lengths and represents a fundamental input for the low energies QCD in the strangeness sector theory. The SIDDHARTA-2 experiment is presently installed at the DAΦNE electronpositron collider at the National Laboratories of Frascati, in Italy. In May 2022, the kaonic $^{4}$He x-ray transitions measurement was performed by the complete SIDDHARTA-2 setup, by using a gaseous target. The result of this measurement is presented in this paper, with a specific focus on the background rejection performed by the kaon trigger system