EU-China relations: through the narrative of China's media

China is the second-biggest trading partner of the European Union, and the EU is the biggest trading partner of China. Hence, it is vital to find the media perception of the EU and the political ideology behind it. This article aims to examine China’s official media perception of the EU by systematically examine the previous study. This study finds that Chinese media frame EU as an economic and political partner in a positive way but try to avoid mentioning the contradiction and friction, the selective negative issues are mainly for propaganda and conform to Chinese government attitude. Hence, this study discusses that Chinese official media follow the narrative of the Chinese government and reflect the EU-China relationship from the Chinese government perspective

AFP-Net: Realtime Anchor-Free Polyp Detection in Colonoscopy

Colorectal cancer (CRC) is a common and lethal disease. Globally, CRC is the third most commonly diagnosed cancer in males and the second in females. For colorectal cancer, the best screening test available is the colonoscopy. During a colonoscopic procedure, a tiny camera at the tip of the endoscope generates a video of the internal mucosa of the colon. The video data are displayed on a monitor for the physician to examine the lining of the entire colon and check for colorectal polyps. Detection and removal of colorectal polyps are associated with a reduction in mortality from colorectal cancer. However, the miss rate of polyp detection during colonoscopy procedure is often high even for very experienced physicians. The reason lies in the high variation of polyp in terms of shape, size, textural, color and illumination. Though challenging, with the great advances in object detection techniques, automated polyp detection still demonstrates a great potential in reducing the false negative rate while maintaining a high precision. In this paper, we propose a novel anchor free polyp detector that can localize polyps without using predefined anchor boxes. To further strengthen the model, we leverage a Context Enhancement Module and Cosine Ground truth Projection. Our approach can respond in real time while achieving state-of-the-art performance with 99.36% precision and 96.44% recall

CCL3 and CCL20-recruited dendritic cells modified by melanoma antigen gene-1 induce anti-tumor immunity against gastric cancer ex vivo and in vivo

<p>Abstract</p> <p>Background</p> <p>To investigate whether dendritic cell (DC) precursors, recruited by injection of <b>chemokine ligand 3 (CCL3) and CCL20</b>, induce anti-tumor immunity against gastric cancer induced by a DC vaccine expressing melanoma antigen gene-1 (MAGE-1) ex vivo and in vivo.</p> <p>Methods</p> <p>B6 mice were injected with CCL3 and CCL20 via the tail vein. Freshly isolated F4/80^-B220^-CD11c⁺cells cultured with cytokines were analyzed by phenotype analysis and mixed lymphocyte reaction (MLR). For adenoviral (Ad)-mediated gene transduction, cultured F4/80^-B220^-CD11c⁺cells were incubated with Ad-MAGE-1. Vaccination of stimulated DC induced T lymphocytes. The killing effect of these T cells against gastric carcinoma cells was assayed by MTT. INF-γ production was determined with an INF-γ ELISA kit. In the solid tumor and metastases model, DC-based vaccines were used for immunization after challenge with MFC cells. <b>Tumor size, survival of mice, and number of pulmonary metastatic foci were used to assess the therapeutic effect of DC vaccines</b>.</p> <p>Results</p> <p>F4/80^-B220^-CD11c⁺cell numbers increased after <b>CCL3 and CCL20 </b>injection. Freshly isolated F4/80^-B220^-CD11c⁺cells cultured with cytokines were phenotyically identical to typical DC and gained the capacity to stimulate allogeneic T cells. These DCs were transduced with Ad-MAGE-1, which were prepared for DC vaccines expressing tumor antigen. T lymphocytes stimulated by DCs transduced with Ad-MAGE-1 exhibited specific killing effects on gastric carcinoma cells and produced high levels of INF-γ ex vivo. In vivo, tumor sizes of the experimental group were much smaller than both the positive control group and the negative control groups (<it>P </it>< 0.05). Kaplan-Meier survival curves showed that survival of the experimental group mice was significantly longer than the control groups (<it>P </it>< 0.05). In addition, MAGE-1-transduced DCs were also a therapeutic benefit on an established metastatic tumor, resulting in a tremendous decrease in the number of pulmonary metastatic foci.</p> <p>Conclusions</p> <p><b>CCL3 and CCL20</b>-recruited DCs modified by adenovirus-trasnsduced, tumor-associated antigen, MAGE-1, can stimulate anti-tumor immunity specific to gastric cancer ex vivo and in vivo. This system may prove to be an efficient strategy for anti-tumor immunotherapy.</p

ANALYSIS AND STUDY ON 47 CASES OF ADVERSE REACTIONS OF CHINESE MEDICINE INJECTION

Background: Along with efficacy, Chinese medicine is increasingly being known to people, Chinese medicine and its preparations are increasingly widespread in clinical use. People generally believe that Chinese medicine has few side effects and is safe, especially Chinese medicine injections. Due to the direct injection in blood, rapid onset and good efficacy, they are welcomed by people. However, with increased use, adverse reactions are increasing, even causing serious consequences. The objective is to learn about the characteristics and laws of the adverse effects of Chinese medicine injections, provide references for the clinical safe drug use, and reduce the incidence of adverse reactions. Materials and Methods: The method was established to analyze the data of 47 cases of adverse reactions caused by Chinese medicine injections in our hospital from the year, 2009 to 2010. Results: The organs / systems involved in the 47 cases of adverse reactions are primarily skin and its accessories and secondly systemic damage, involving a total of eight varieties of drugs. Conclusion: The adverse reactions of Chinese medicine injections are mostly in Chinese patent drugs, which should be paid attention to, to find out the problems and laws, use the drugs rationally, and reduce the incidence of the adverse reactions

Explore postgraduate biomedical engineering course integration between medical signal processing and drug development: example for drug development in brain disease

Medical signal processing is a compulsory course in our university’s undergraduate biomedical engineering programme. Recently, application of medical signal processing in supporting new drug development has emerged as a promising strategy in neurosciences. Here, we discuss the curriculum reformation in biomedical signal processing course in the context of drug development and application in central nervous system, with a particular emphasis in knowledge integration

Specialization and Market Penetration of Bilateral Trade between Peru and United States: An Exploratory Analysis

This paper aims to investigate the dynamics of bilateral trade, specialization and export market penetration of Peru's trade with the United States of America. This research explored Peru's potentials in export market penetration with the United States for 16 industry sectors. The paper also applied the Export Intensity, Import Intensity, Trade Intensity and Revealed Comparative Advantage (RCA) indices by analyzing data from 1992 to 2017 of 16 industry sectors (HS2 digits classification) of Peru's trade with the United States. The investigation over the trading relationship between the two countries in the mentioned indexes revealed the status of specialization and market penetration of Peru for its 16-industry sector's trade with the United States. The results stated several measures and policy implications to be implemented for improving the specialization of the mentioned sectors of Peru's trade with the United States as well as it will contribute to the academic literature in this area. Key Words: Sectorial Analysis, Export Specialization, Market Penetration, Peru, The United States JEL Classification: F12, F13, F14, O24 DOI: 10.7176/JESD/12-12-11 Publication date:June 30th 202