458 research outputs found
Enseigner dans le supérieur : une approche des formations à la pédagogie par les compétences
De lâĂ©cole maternelle Ă lâuniversitĂ©, le mĂ©tier d\u27enseignant se transforme : autonomie et responsabilitĂ© accrues, pĂ©dagogies diffĂ©renciĂ©es, centration sur les dispositifs et les situations d\u27apprentissage, sensibilitĂ© au rapport au savoir, usage des TIC, pratique rĂ©flexive, professionnalisation, travail en Ă©quipe et par projets, accueil de nouveaux publicsâŠautant dâĂ©lĂ©ments qui renforcent les pratiques novatrices de formation des enseignants, notamment Ă lâuniversitĂ©, et lâadoption dâune dĂ©marche par les compĂ©tences du mĂ©tier dâenseignant. LâuniversitĂ© dâAngers a proposĂ© un rĂ©fĂ©rentiel de compĂ©tences des enseignants en concertation avec toutes les parties prenantes de lâinstitution, et a dĂ©fini les formations adaptĂ©es, destinĂ©es aux enseignants nouvellement recrutĂ©s et aux plus expĂ©rimentĂ©s qui pourront rĂ©flĂ©chir sur leurs pratiques pĂ©dagogiques et les faire Ă©voluer. PremiĂšre Ă©tape vers une formation pĂ©dagogique professionnelle continue, ce plan de formation balise ainsi un passage du statut dâĂ©tudiant Ă celui dâenseignant universitaire professionnel
Corporate social responsibility under the Petroleum Industry Act 2021: achieving environmental sustainability through multi-stakeholder partnership.
Several attempts have been made by the Nigerian government to reform the oil and gas industry. In March 2007, the first attempt to introduce the Corporate Social Responsibility (CSR) Bill was initiated by the late Senator Uche Chwukwumerije, but it failed to pass the second reading. Further attempts to reform the industry in 2009, 2012 and 2018 also failed, until the National Assembly passed the 2021 Petroleum Industry Bill, now known as the Petroleum Industry Act 2021 (PIA). Chapter 3 Section 240 (2) of the PIA has changed the voluntary and self-regulatory element of CSR to "hard" law, by making CSR contribution a mandatory levy on corporations. The authors are of the view that a multi-stakeholder approach and multi-stakeholder framework - comprising host communities, oil and gas companies as well as government - is essential to achieving the broad requirements of CSR in the Nigerian oil and gas industry. In this paper, we analyse this approach in line with the role and challenges of CSR, as provided for under the PIA
A concept for a novel polymer extruder part 2: rotational barrel segment
This paper presents a novel concept of an extrusion machine for polymer plastics, polymer-matrix
materials, and food processing applications. The design of the extruder includes a rotational barrel
segment to enable kinematic activation in the process of plasticizing the material and improvement
in the homogenization level. The tests included a FEM-based numerical analysis of the rotational
barrel segment design. The numerical calculations comprised a fully coupled thermal-stress
analysis, used to solve a non-linear geometric and physical problem. The numerical calculation
results proved that the designed structural parts of the rotational barrel segment had sufficient
strength and that the design of the rotational barrel segment was suitable in terms of the required
temperature distribution within the structural parts. The numerical calculation tool used in the
analysis was ABAQUS , commercially available software
A concept for a novel polymer extruder part 1: active grooved feed section
This paper presents a novel concept for an extruder to be used with plastics and polymer
composites, especially in the food industry. The design solutions include a grooved feed section
with adjustable geometric parameters, which makes it possible for dynamic adjustment of the
depth, inclination angle and number of grooves used for granulate transport during continuous
operation of the machine. The proposed grooved feed section concept facilitates optimum
performance, and is adjustable to suit the general parameters of production. The scope of our study
also included the numerical strength and thermal analysis of the designed grooved feed section,
conducted using the finite element method. Numerical calculation involved a coupled temperaturedisplacement
analysis which constituted a geometrically and physically non-linear problem. The
results corroborated the achievement of satisfactory strength for the structural elements of the
grooved feed section in the extruder and demonstrated the suitability of the adopted solution in
terms of temperature distribution in the parts of the machine, as well as the correct concept of the
rcial program
Characterization of the cofactor-binding site in the SPOUT-fold methyltransferases by computational docking of S-adenosylmethionine to three crystal structures
BACKGROUND: There are several evolutionarily unrelated and structurally dissimilar superfamilies of S-adenosylmethionine (AdoMet)-dependent methyltransferases (MTases). A new superfamily (SPOUT) has been recently characterized on a sequence level and three structures of its members (1gz0, 1ipa, and 1k3r) have been solved. However, none of these structures include the cofactor or the substrate. Due to the strong evolutionary divergence and the paucity of experimental information, no confident predictions of protein-ligand and protein-substrate interactions could be made, which hampered the study of sequence-structure-function relationships in the SPOUT superfamily. RESULTS: We used the computational docking program AutoDock to identify the AdoMet-binding site on the surface of three MTase structures. We analyzed the sequence divergence in two distinct lineages of the SPOUT superfamily in the context of surface features and preferred cofactor binding mode to propose specific function for the conserved residues. CONCLUSION: Our docking analysis has confidently predicted the common AdoMet-binding site in three remotely related proteins structures. In the vicinity of the cofactor-binding site, subfamily-conserved grooves were identified on the protein surface, suggesting location of the target-binding/catalytic site. Functionally important residues were inferred and a general reaction mechanism, involving conformational change of a glycine-rich loop, was proposed
Une dĂ©marche CompĂ©tences pour des formations pĂ©dagogiques professionnelles dans lâEnseignement SupĂ©rieur
Devenu incontournable dans les travaux de recherche sur la pĂ©dagogie, le concept de « compĂ©tences » connaĂźt un fort succĂšs aux Etats-Unis, au QuĂ©bec, en Suisse, en France, dans la CommunautĂ© française de Belgique et aux Pays-Bas. Largement rĂ©pandu Ă©galement en entreprise, ce concept polysĂ©mique a contribuĂ© Ă faire Ă©voluer le contenu des formations universitaires, quâelles soient professionnalisantes ou de recherche. Des curricula se sont multipliĂ©s, des rĂ©fĂ©rentiels de compĂ©tences « professionnelles » ont Ă©tĂ© dĂ©finis, des arbres de compĂ©tences et des portfolios ont Ă©tĂ© dĂ©veloppĂ©s et les certifications professionnelles sont lĂ©gionâŠ
Mais face Ă cet engouement, pourrait apparaĂźtre une forme dâobsession de lâidĂ©e de « compĂ©tences » au risque dâentraĂźner une « pensĂ©e pĂ©dagogique unique » censĂ©e servir le politique, lâentreprise et la socialisation Ă©conomique
Signatures of the disk-jet coupling in the Broad-line Radio Quasar 4C+74.26
Here we explore the disk-jet connection in the broad-line radio quasar
4C+74.26, utilizing the results of the multiwavelength monitoring of the
source. The target is unique in that its radiative output at radio wavelengths
is dominated by a moderately-beamed nuclear jet, at optical frequencies by the
accretion disk, and in the hard X-ray range by the disk corona. Our analysis
reveals a correlation (local and global significance of 96\% and 98\%,
respectively) between the optical and radio bands, with the disk lagging behind
the jet by days. We discuss the possible explanation for this,
speculating that the observed disk and the jet flux changes are generated by
magnetic fluctuations originating within the innermost parts of a truncated
disk, and that the lag is related to a delayed radiative response of the disk
when compared with the propagation timescale of magnetic perturbations along
relativistic outflow. This scenario is supported by the re-analysis of the
NuSTAR data, modelled in terms of a relativistic reflection from the disk
illuminated by the coronal emission, which returns the inner disk radius
. We discuss the global energetics in
the system, arguing that while the accretion proceeds at the Eddington rate,
with the accretion-related bolometric luminosity erg s , the jet total kinetic energy
erg s, inferred from the dynamical
modelling of the giant radio lobes in the source, constitutes only a small
fraction of the available accretion power.Comment: 9 pages and 6 figures, ApJ accepte
The Enzymatic Activity of Type 1 Iodothyronine Deiodinase (D1) is Low in Liver Hemangioma: A Preliminary Study
Type 1 iodothyronine deiodinase (D1) is a crucial enzyme which converts the prohormone thyroxine (T4) into active tri-iodothyronine (T3). There has been strong evidence that the metabolism of thyroid hormones is disturbed in some neoplastic tissues such as thyroid, renal, and breast cancer. However, there are few available data about D1 enzyme activity in benign tumors such as hemangioma, which is the most common primary liver tumor. Hence this study aimed to determine the enzymatic activity of D1 in hemangiomas in relation to healthy liver tissue. Seven tumors and healthy control tissues were obtained from patients who had liver resection due to hemangioma. The activity was assessed by measurement of radioactive iodine released by deiodination catalyzed by D1. It was found that D1 activity was significantly lower in the hemagiomas than in the healthy surrounding tissue (p = 0.0017). The results indicated that thyroid hormones play important roles not only in the regulation of cell metabolism, but also in cell growth, division, and apoptosis. The active form T3 acts through its nuclear receptors and influences the up- and down-regulation of target genes. Healthy liver tissue expresses a high level of D1, but disturbed D1 activity may result in changes in the local concentration of T3 which may impair gene transcription. These finding demonstrate a low enzymatic activity of D1 in liver hemangioma and suggest an as yet unknown role of thyroid hormones in this type of benign liver tumor
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