A High-Eccentricity Low-Mass Companion to HD 89744

HD 89744 is an F7 V star with mass 1.4 M, effective temperature 6166 K, age 2.0 Gy and metallicity [Fe/H]= 0.18. The radial velocity of the star has been monitored with the AFOE spectrograph at the Whipple Observatory since 1996, and evidence has been found for a low mass companion. The data were complemented by additional data from the Hamilton spectrograph at Lick Observatory during the companion's periastron passage in fall 1999. As a result, we have determined the star's orbital wobble to have period P = 256 d, orbital amplitude K = 257 m/s, and eccentricity e = 0.7. From the stellar mass we infer that the companion has minimum mass m2 sin i = 7.2 MJup in an orbit with semi-major axis a2 = 0.88 AU. The eccentricity of the orbit, among the highest known for extra-solar planets, continues the trend that extra-solar planets with semi-major axes greater than about 0.15 AU tend to have much higher eccentricities than are found in our solar system. The high metallicity of the parent star reinforces the trend that parent stars of extra-solar planets tend to have high metallicityComment: AASTEX-LateX v5.0, 7 pages w/ 3 figures, to be published in ApJ

An Eccentric Hot Jupiter Orbiting the Subgiant HD 185269

We report the detection of a Jupiter-mass planet in a 6.838 day orbit around the 1.28 solar mass subgiant HD 185269. The eccentricity of HD 185269b (e = 0.30) is unusually large compared to other planets within 0.1 AU of their stars. Photometric observations demonstrate that the star is constant to +/-0.0001 mag on the radial velocity period, strengthening our interpretation of a planetary companion. This planet was detected as part of our radial velocity survey of evolved stars located on the subgiant branch of the H-R diagram--also known as the Hertzsprung Gap. These stars, which have masses between 1.2 and 2.5 solar masses, play an important role in the investigation of the frequency of extrasolar planets as a function of stellar mass.Comment: 18 pages, 4 figures, 3 tables, ApJ in press (scheduled for Dec 2006, v652n2

Ten Low Mass Companions from the Keck Precision Velocity Survey

Ten new low mass companions have emerged from the Keck precision Doppler velocity survey, with minimum (msini) masses ranging from 0.8 mjup to 0.34 msun. Five of these are planet candidates with msini < 12 mjup, two are brown dwarf candidates with msini ~30 mjup, and three are low mass stellar companions. Hipparcos astrometry reveals the orbital inclinations and masses for three of the (more massive) companions, and it provides upper limits to the masses for the rest. A new class of extrasolar planet is emerging, characterized by nearly circular orbits and orbital radii greater than 1 AU. The planet HD 4208b appears to be a member of this new class. The mass distribution of extrasolar planets continues to exhibit a rapid rise from 10 mjup toward the lowest detectable masses near 1 msat.Comment: 26 pages, TeX, plus 13 postscript figure

Precise Radial Velocities of Giant Stars II. Pollux and its Planetary Companion

It has long been speculated that the observed periodic radial velocity pattern for the K giant Pollux might be explained in terms of an orbiting planetary companion. We have collected 80 high-resolution spectra for Pollux at Lick Observatory yielding precise radial velocities with a mean error of 3.8 m/s, providing the most comprehensive and precise data set available for this star. Our data confirm the periodicity previously seen in the radial velocities. We derive a period of 589.7+/-3.5 days and, assuming a primary mass of 1.86 M_Sun, a minimum companion mass of 2.9+/-0.3 M_Jup, consistent with earlier determinations. No evidence for any periodicities is visible in our analysis of the shapes of the spectral lines via the bisector method, so that we conclude that evidence is accumulating and compelling for a planet around Pollux. However, some last doubt remains about this interpretation, because non-radial pulsations which might be present in giant stars could in principle also explain the observed radial velocities, while the accompanying bisector variations might be too small to be detectable with current data.Comment: 13 pages, 4 figures, accepted by Ap

A Planet at 5 AU Around 55 Cancri

We report precise Doppler shift measurements of 55 Cancri (G8V) obtained from 1989 to 2002 at Lick Observatory. The velocities reveal evidence for an outer planetary companion to 55 Cancri orbiting at 5.5 AU. The velocities also confirm a second, inner planet at 0.11 AU. The outer planet is the first extrasolar planet found that orbits near or beyond the orbit of Jupiter. It was drawn from a sample of ~50 stars observed with sufficient duration and quality to detect a giant planet at 5 AU, implying that such planets are not rare. The properties of this jupiter analog may be compared directly to those of the Jovian planets in our Solar System. Its eccentricity is modest, e=0.16, compared with e=0.05 for both Jupiter and Saturn. Its mass is at least 4.0 jupiter masses (M sin i). The two planets do not perturb each other significantly. Moreover, a third planet of sub-Jupiter mass could easily survive in between these two known planets. Indeed a third periodicity remains in the velocity measurements with P = 44.3 d and a semi-amplitude of 13 m/s. This periodicity is caused either by a third planet at a=0.24 AU or by inhomogeneities on the stellar surface that rotates with period 42 d. The planet interpretation is more likely, as the stellar surface is quiet, exhibiting log(R'_{HK}) = -5.0 and brightness variations less than 1 millimag, and any hypothetical surface inhomogeneity would have to persist in longitude for 14 yr. Even with all three planets, an additional planet of terrestrial--mass could orbit stably at ~1 AU. The star 55 Cancri is apparently a normal, middle-aged main sequence star with a mass of 0.95 solar masses, rich in heavy elements ([Fe/H] = +0.27). This high metallicity raises the issue of the relationship between its age, rotation, and chromosphere.Comment: 47 pages, 4 tables, 12 figures, uses AASTE

Retired A Stars and Their Companions. III. Comparing the Mass-Period Distributions of Planets Around A-Type Stars and Sun-Like Stars

We present an analysis of ~5 years of Lick Observatory radial velocity measurements targeting a uniform sample of 31 intermediate-mass subgiants (1.5 < M*/Msun < 2.0) with the goal of measuring the occurrence rate of Jovian planets around (evolved) A-type stars and comparing the distributions of their orbital and physical characteristics to those of planets around Sun-like stars. We provide updated orbital solutions incorporating new radial velocity measurements for five known planet-hosting stars in our sample; uncertainties in the fitted parameters are assessed using a Markov Chain Monte Carlo method. The frequency of Jovian planets interior to 3 AU is 26 (+9,-8)%, which is significantly higher than the ~5-10% frequency observed around solar-mass stars. The median detection threshold for our sample includes minimum masses down to {0.2, 0.3, 0.5, 0.6, 1.3} MJup within {0.1, 0.3, 0.6, 1.0, 3.0} AU. To compare the properties of planets around intermediate-mass stars to those around solar-mass stars we synthesize a population of planets based on the parametric relationship dN ~ M^{alpha}P^{beta} dlnM dlnP, the observed planet frequency, and the detection limits we derived. We find that the values of alpha and beta for planets around solar-type stars from Cumming et al. fail to reproduce the observed properties of planets in our sample at the 4 sigma level, even when accounting for the different planet occurrence rates. Thus, the properties of planets around A stars are markedly different than those around Sun-like stars, suggesting that only a small (~ 50%) increase in stellar mass has a large influence on the formation and orbital evolution of planets.Comment: Accepted by the Astrophysical Journal; 15 pages, 15 figure

MerTK inhibition in tumor leukocytes decreases tumor growth and metastasis

MerTK, a receptor tyrosine kinase (RTK) of the TYRO3/AXL/MerTK family, is expressed in myeloid lineage cells in which it acts to suppress proinflammatory cytokines following ingestion of apoptotic material. Using syngeneic mouse models of breast cancer, melanoma, and colon cancer, we found that tumors grew slowly and were poorly metastatic in MerTK–/– mice. Transplantation of MerTK–/– bone marrow, but not wild-type bone marrow, into lethally irradiated MMTV-PyVmT mice (a model of metastatic breast cancer) decreased tumor growth and altered cytokine production by tumor CD11b+ cells. Although MerTK expression was not required for tumor infiltration by leukocytes, MerTK–/– leukocytes exhibited lower tumor cell–induced expression of wound healing cytokines, e.g., IL-10 and growth arrest-specific 6 (GAS6), and enhanced expression of acute inflammatory cytokines, e.g., IL-12 and IL-6. Intratumoral CD8+ T lymphocyte numbers were higher and lymphocyte proliferation was increased in tumor-bearing MerTK–/– mice compared with tumor-bearing wild-type mice. Antibody-mediated CD8+ T lymphocyte depletion restored tumor growth in MerTK–/– mice. These data demonstrate that MerTK signaling in tumor-associated CD11b+ leukocytes promotes tumor growth by dampening acute inflammatory cytokines while inducing wound healing cytokines. These results suggest that inhibition of MerTK in the tumor microenvironment may have clinical benefit, stimulating antitumor immune responses or enhancing immunotherapeutic strategies

PTB Domain-Directed Substrate Targeting in a Tyrosine Kinase from the Unicellular Choanoflagellate Monosiga brevicollis

Choanoflagellates are considered to be the closest living unicellular relatives of metazoans. The genome of the choanoflagellate Monosiga brevicollis contains a surprisingly high number and diversity of tyrosine kinases, tyrosine phosphatases, and phosphotyrosine-binding domains. Many of the tyrosine kinases possess combinations of domains that have not been observed in any multicellular organism. The role of these protein interaction domains in M. brevicollis kinase signaling is not clear. Here, we have carried out a biochemical characterization of Monosiga HMTK1, a protein containing a putative PTB domain linked to a tyrosine kinase catalytic domain. We cloned, expressed, and purified HMTK1, and we demonstrated that it possesses tyrosine kinase activity. We used immobilized peptide arrays to define a preferred ligand for the third PTB domain of HMTK1. Peptide sequences containing this ligand sequence are phosphorylated efficiently by recombinant HMTK1, suggesting that the PTB domain of HMTK1 has a role in substrate recognition analogous to the SH2 and SH3 domains of mammalian Src family kinases. We suggest that the substrate recruitment function of the noncatalytic domains of tyrosine kinases arose before their roles in autoinhibition

Structure and Evolution of Nearby Stars with Planets II. Physical Properties of ~1000 Cool Stars from the SPOCS Catalog

We derive detailed theoretical models for 1074 nearby stars from the SPOCS (Spectroscopic Properties of Cool Stars) Catalog. The California and Carnegie Planet Search has obtained high-quality echelle spectra of over 1000 nearby stars taken with the Hamilton spectrograph at Lick Observatory, the HIRES spectrograph at Keck, and UCLES at the Anglo Australian Observatory. A uniform analysis of the high-resolution spectra has yielded precise stellar parameters, enabling systematic error analyses and accurate theoretical stellar modeling. We have created a large database of theoretical stellar evolution tracks using the Yale Stellar Evolution Code (YREC) to match the observed parameters of the SPOCS stars. Our very dense grids of evolutionary tracks eliminate the need for interpolation between stellar evolutionary tracks and allow precise determinations of physical stellar parameters (mass, age, radius, size and mass of the convective zone, etc.). Combining our stellar models with the observed stellar atmospheric parameters and uncertainties, we compute the likelihood for each set of stellar model parameters separated by uniform time steps along the stellar evolutionary tracks. The computed likelihoods are used for a Bayesian analysis to derive posterior probability distribution functions for the physical stellar parameters of interest. We provide a catalog of physical parameters for 1074 stars that are based on a uniform set of high quality spectral observations, a uniform spectral reduction procedure, and a uniform set of stellar evolutionary models. We explore this catalog for various possible correlations between stellar and planetary properties, which may help constrain the formation and dynamical histories of other planetary systems.Comment: 28 pages, 19 figures, 5 tables, Accepted for publication in ApJS; the catalog of stellar parameters is available at http://exoplanets.org/SPOCS_evol.htm

Implications For The Origin Of GRB 051103 From LIGO Observations

We present the results of a LIGO search for gravitational waves (GWs) associated with GRB 051103, a short-duration hard-spectrum gamma-ray burst (GRB) whose electromagnetically determined sky position is coincident with the spiral galaxy M81, which is 3.6 Mpc from Earth. Possible progenitors for short-hard GRBs include compact object mergers and soft gamma repeater (SGR) giant flares. A merger progenitor would produce a characteristic GW signal that should be detectable at the distance of M81, while GW emission from an SGR is not expected to be detectable at that distance. We found no evidence of a GW signal associated with GRB 051103. Assuming weakly beamed gamma-ray emission with a jet semi-angle of 30 deg we exclude a binary neutron star merger in M81 as the progenitor with a confidence of 98%. Neutron star-black hole mergers are excluded with > 99% confidence. If the event occurred in M81 our findings support the the hypothesis that GRB 051103 was due to an SGR giant flare, making it the most distant extragalactic magnetar observed to date.Comment: 8 pages, 3 figures. For a repository of data used in the publication, go to: https://dcc.ligo.org/cgi-bin/DocDB/ShowDocument?docid=15166 . Also see the announcement for this paper on ligo.org at: http://www.ligo.org/science/Publication-GRB051103/index.ph