New Russulaceae species in south-east Queensland

Russula species are ectomycorrhizal basidiomycetes common throughout Australian woodlands. Molecular and morphological examination of Russula specimens from various sites in South-east Queensland has uncovered a number of phylogenetically diverse and potentially undescribed specimens. At this stage, most of these remain as individual specimens. However, several specimens have been grouped into project species. In this presentation, two potentially new species of Russula will be described. Both species are widespread on red to black clay soils in the Toowoomba region and appear to be phylogenetically related to each other. Project species 1 has a white stipe which developed a pink flush after collection and red to pink centrally depressed cap with white gills. The spores of this species were subglobose, white and ornamented with amyloid warts connected in short chains. The second species, project species 3, is macroscopically similar, differing with its larger size, purple-pink cap colour, and rougher cap texture. Its spores are globose to subglobose, white and ornamented with small amyloid warts connected in short chains. Continued molecular and morphological studies of the Russula species of South-east Queensland may uncover more novel Australian species

Molecular taxonomy of Australian endophytic Pezizales

The order Pezizales contains a wide variety of striking macro ascomycetes not commonly observed in Australia. Known as cup fungi and false morels due to the prominent, often brightly coloured apothecia that are produced, most samples may be observed on the ground or on decaying leaf and bark material. Recently, 33 likely novel isolates belonging to Sarcosomataceae and Sarcoscyphaceae were found occurring endophytically in leaves collected from a semi evergreen vine thicket in the Brigalow Belt in South-East Queensland. An endophytic life mode is considered rare for these families and so this observation raises interesting ecological questions. The 33 isolates were analysed to determine their phylogenetic relationship with other known Sarcosomataceae and Sarcoscyphaceae and found to belong to three potentially new genera. This observation represents an increase in the observance of Sarcosomataceae in Australia and also a possible range expansion for one genus within the Sarcoscyphaceae

Molecular dynamics simulations of oxide memory resistors (memristors)

Reversible bipolar nano-switches that can be set and read electronically in a solid-state two-terminal device are very promising for applications. We have performed molecular-dynamics simulations that mimic systems with oxygen vacancies interacting via realistic potentials and driven by an external bias voltage. The competing short- and long-range interactions among charged mobile vacancies lead to density fluctuations and short-range ordering, while illustrating some aspects of observed experimental behavior, such as memristor polarity inversion.Comment: 15 pages, 5 figure

Cryosurgery Versus Primary Androgen Deprivation Therapy for Locally Recurrent Prostate Cancer After Primary Radiotherapy: A Propensity-Matched Survival Analysis.

Background Optimal management of isolated local recurrence of prostate cancer after primary radiotherapy remains to be defined. Up-front androgen deprivation therapy (ADT) is widely used but may adversely affect the quality of life and is essentially a palliative treatment. Local salvage carries a different side-effect profile and is potentially curative, but it has not been compared to ADT. Materials and methods We conducted a propensity-matched analysis of cohorts of men treated with either whole gland cryotherapy (CRYO) or primary ADT following the diagnosis of locally recurrent prostate cancer. Our specific objectives were to compare overall survival (OS) and prostate cancer-specific mortality (PCSM) between CRYO vs. ADT. Results After a one-to-one matching, 169 patients from each cohort were included in comparisons. Median follow-up time was 6.7 years (ADT) vs. 18 years (CRYO). The 10-year PCSM was 18.5% (ADT) vs. 16.2% (CRYO), which was not statistically different [hazard ratioo (HR): 0.69, 95% CI: 0.36-1.34, p=0.27]. The median OS was 12.3 years (CRYO) versus 10.2 years (ADT) (HR: 0.63, 95% CI: 0.42-0.95, p=0.03). Conclusions While PCSM was similar between the two strategies, CRYO was associated with a longer OS compared to primary ADT. Given the retrospective nature of the trial, these results should be considered hypothesis-generating, and phase III trials comparing these two options are required to further explore these findings

High dose BCNU chemotherapy with autologous bone marrow transplantation and full dose radiotherapy for grade IV astrocytoma.

In a series of 22 patients, high dose BCNU (800-1,000mg m-2) with autologous bone marrow transplantation was given as the first post-surgical treatment for grade IV astrocytoma and followed by full dose radiotherapy. When compared to historical experience and matched to control patients in national studies, there appeared to be a small prolongation of survival but no increase in the proportion of long survivors. Acute myelosuppression was mild but toxicity to lung and liver was substantial and limited further dose escalation. Late bone marrow failure was seen in 4 patients. Pharmacokinetic studies were performed and suggested that the late marrow failure was due to persistence of BCNU at the time of marrow return. Despite the suggestion of a prolongation of survival this approach is not routinely recommended and a randomised trial is probably not justified