Microwave scattering and emission properties of large impact craters on the surface of Venus

Many of the impact craters on Venus imaged by the Magellan synthetic aperture radar (SAR) have interior floors with oblique incidence angle backscatter cross sections 2 to 16 times (3 dB to 12 dB) greater than the average scattering properties of the planet's surface. Such high backscatter cross sections are indicative of a high degree of wavelength-scale surface roughness and/or a high intrinsic reflectivity of the material forming the crater floors. Fifty-three of these (radar) bright floored craters are associated with 93 percent of the parabolic-shaped radar-dark features found in the Magellan SAR and emissivity data, features that are thought to be among the youngest on the surface of Venus. It was suggested by Campbell et al. that either the bright floors of the parabolic feature parent craters are indicative of a young impact and the floor properties are modified with time to a lower backscatter cross section or that they result from some property of the surface or subsurface material at the point of impact or from the properties of the impacting object. As a continuation of earlier work we have examined all craters with diameters greater than 30 km (except 6 that were outside the available data) so both the backscatter cross section and emissivity of the crater floors could be estimated from the Magellan data

Acute neuroinflammation induces AIS structural plasticity in a NOX2-dependent manner

Background Chronic microglia-mediated inflammation and oxidative stress are well-characterized underlying factors in neurodegenerative disease, whereby reactive inflammatory microglia enhance ROS production and impact neuronal integrity. Recently, it has been shown that during chronic inflammation, neuronal integrity is compromised through targeted disruption of the axon initial segment (AIS), the axonal domain critical for action potential initiation. AIS disruption was associated with contact by reactive inflammatory microglia which wrap around the AIS, increasing association with disease progression. While it is clear that chronic microglial inflammation and enhanced ROS production impact neuronal integrity, little is known about how acute microglial inflammation influences AIS stability. Here, we demonstrate that acute neuroinflammation induces AIS structural plasticity in a ROS-mediated and calpain-dependent manner. Methods C57BL/6J and NOX2−/− mice were given a single injection of lipopolysaccharide (LPS; 5 mg/kg) or vehicle (0.9% saline, 10 mL/kg) and analyzed at 6 h–2 weeks post-injection. Anti-inflammatory Didox (250 mg/kg) or vehicle (0.9% saline, 10 mL/kg) was administered beginning 24 h post-LPS injection and continued for 5 days; animals were analyzed 1 week post-injection. Microglial inflammation was assessed using immunohistochemistry (IHC) and RT-qPCR, and AIS integrity was quantitatively analyzed using ankyrinG immunolabeling. Data were statistically compared by one-way or two-way ANOVA where mean differences were significant as assessed using Tukey’s post hoc analysis. Results LPS-induced neuroinflammation, characterized by enhanced microglial inflammation and increased expression of ROS-producing enzymes, altered AIS protein clustering. Importantly, inflammation-induced AIS changes were reversed following resolution of microglial inflammation. Modulation of the inflammatory response using anti-inflammatory Didox, even after significant AIS disruption occurred, increased the rate of AIS recovery. qPCR and IHC analysis revealed that expression of microglial NOX2, a ROS-producing enzyme, was significantly increased correlating with AIS disruption. Furthermore, ablation of NOX2 prevented inflammation-induced AIS plasticity, suggesting that ROS drive AIS structural plasticity. Conclusions In the presence of acute microglial inflammation, the AIS undergoes an adaptive change that is capable of spontaneous recovery. Moreover, recovery can be therapeutically accelerated. Together, these findings underscore the dynamic capabilities of this domain in the presence of a pathological insult and provide evidence that the AIS is a viable therapeutic target

Patients with diabetes in the intensive care unit; not served by treatment, yet protected?

Diabetes is associated with severe complications and decreased life expectancy. However, in the previous issue of Critical Care, Vincent and colleagues report no difference in mortality between patients with insulin-treated diabetes and patients without diabetes in the intensive care unit (ICU), despite larger severity of illness in the diabetes group at admission. This study contributes to the growing evidence that diabetes in itself is not a risk factor for ICU mortality, although the mechanisms are not yet fully understood. On the other hand, patients with diabetes seem not to benefit from tight glycemic control during their ICU stay. Different treatment approaches may be needed for patients with diabetes and patients with stress hyperglycemia

Exoskeletal predator defenses of juvenile California spiny lobsters (Panulirus interruptus) are affected by fluctuating ocean acidification-like conditions

Spiny lobsters rely on multiple biomineralized exoskeletal predator defenses that may be sensitive to ocean acidification (OA). Compromised mechanical integrity of these defensive structures may tilt predator-prey outcomes, leading to increased mortality in the lobsters’ environment. Here, we tested the effects of OA-like conditions on the mechanical integrity of selected exoskeletal defenses of juvenile California spiny lobster, Panulirus interruptus. Young spiny lobsters reside in kelp forests with dynamic carbonate chemistry due to local metabolism and photosynthesis as well as seasonal upwelling, yielding daily and seasonal fluctuations in pH. Lobsters were exposed to a series of stable and diurnally fluctuating reduced pH conditions for three months (ambient pH/stable, 7.97; reduced pH/stable 7.67; reduced pH with low fluctuations, 7.67 ± 0.05; reduced pH with high fluctuations, 7.67 ± 0.10), after which we examined the intermolt composition (Ca and Mg content), ultrastructure (cuticle and layer thickness), and mechanical properties (hardness and stiffness) of selected exoskeletal predator defenses. Cuticle ultrastructure was consistently robust to pH conditions, while mineralization and mechanical properties were variable. Notably, the carapace was less mineralized under both reduced pH treatments with fluctuations, but with no effect on material properties, and the rostral horn had lower hardness in reduced/high fluctuating conditions without a corresponding difference in mineralization. Antennal flexural stiffness was lower in reduced, stable pH conditions compared to the reduced pH treatment with high fluctuations and not correlated with changes in cuticle structure or mineralization. These results demonstrate a complex relationship between mineralization and mechanical properties of the exoskeleton under changing ocean chemistry, and that fluctuating reduced pH conditions can induce responses not observed under the stable reduced pH conditions often used in OA research. Furthermore, this study shows that some juvenile California spiny lobster exoskeletal defenses are responsive to changes in ocean carbonate chemistry, even during the intermolt period, in ways that can potentially increase susceptibility to predation among this critical life stage

The WHO 2013 oral glucose tolerance test:The utility of isolated glucose measurements - A retrospective cohort study

Objective: The WHO 2013 guidelines recommend screening for gestational diabetes mellitus (GDM) by 3-point oral glucose tolerance test (OGTT). The objective of this retrospective cohort study was to evaluate GDM diagnosed by an isolated high glucose. Study design: We included pregnant women deemed at risk for GDM were offered GDM screening. We examined the records of 1939 consecutively screened pregnancies at two teaching hospitals in Amsterdam during 2016–2020. Using the WHO 2013 diagnostic criteria, we calculated the proportion of GDM cases diagnosed by isolated abnormal glucose values. Results: Among those screened in our high risk cohort, GDM incidence was 31.5%. Of the GDM diagnoses, 57.0% were based on an isolated fasting glucose value, 30.9% based on multiple raised glucose measurements, 7.4% on an isolated raised 2-hour glucose and 4.7% on an isolated raised 1-hour glucose. For 1-hour glucose, the number needed to screen was 67 persons for one additional GDM case. Conclusion: The 1-hour glucose in the 3 point OGTT, as suggested by the WHO 2013 guidelines for GDM, contributes only small numbers of GDM cases and a high number needed to screen (67 for 1 additional case in a selective high risk GDM screening strategy), and is likely even less effective in universally screened populations.</p

The effect of beta-alanine supplementation on neuromuscular fatigue in elderly (55–92 Years): a double-blind randomized study

<p>Abstract</p> <p>Background</p> <p>Ageing is associated with a significant reduction in skeletal muscle carnosine which has been linked with a reduction in the buffering capacity of muscle and in theory, may increase the rate of fatigue during exercise. Supplementing beta-alanine has been shown to significantly increase skeletal muscle carnosine. The purpose of this study, therefore, was to examine the effects of ninety days of beta-alanine supplementation on the physical working capacity at the fatigue threshold (PWC_FT) in elderly men and women.</p> <p>Methods</p> <p>Using a double-blind placebo controlled design, twenty-six men (n = 9) and women (n = 17) (age ± SD = 72.8 ± 11.1 yrs) were randomly assigned to either beta-alanine (BA: 800 mg × 3 per day; n = 12; CarnoSyn™) or Placebo (PL; n = 14) group. Before (pre) and after (post) the supplementation period, participants performed a discontinuous cycle ergometry test to determine the PWC_FT.</p> <p>Results</p> <p>Significant increases in PWC_FT(28.6%) from pre- to post-supplementation were found for the BA treatment group (p < 0.05), but no change was observed with PL treatment. These findings suggest that ninety days of BA supplementation may increase physical working capacity by delaying the onset of neuromuscular fatigue in elderly men and women.</p> <p>Conclusion</p> <p>We suggest that BA supplementation, by improving intracellular pH control, improves muscle endurance in the elderly. This, we believe, could have importance in the prevention of falls, and the maintenance of health and independent living in elderly men and women.</p

All-solid-state electrochromic reflectance device for emittance modulation in the far-infrared spectral region

All-solid-state electrochromic reflectance devices for thermal emittance modulation were designed for operation in the spectral region from mid- to far-infrared wavelengths (2–40 μm). All device constituent layers were grown by magnetron sputtering. The electrochromic (polycrystalline WO3), ion conductor (Ta2O5), and Li+ ion-storage layer (amorphous WO3), optimized for their infrared (IR) optical thicknesses, are sandwiched between a highly IR reflecting Al mirror, and a 90% IR transmissive Al grid top electrode, thereby meeting the requirements for a reversible Li+ ion insertion electrochromic device to operate within the 300 K blackbody emission range. Multicycle optical switching and emittance modulation is demonstrated. The measured change in emissivity of the device is to 20%

Self-Consistent Relativistic Calculation of Nucleon Mean Free Path

We present a fully self-consistent and relativistic calculation of the nucleon mean free path in nuclear matter and finite nuclei. Starting from the Bonn potential, the Dirac-Brueckner-Hartree-Fock results for nuclear matter are parametrized in terms of an effective $\sigma$-$\omega$ Lagrangian suitable for the relativistic density-dependent Hartree-Fock (RDHF) approximation. The nucleon mean free path in nuclear matter is derived from this effective Lagrangian taking diagrams up to fourth-order into account. For the nucleon mean free path in finite nuclei, we make use of the density determined by the RDHF calculation in the local density approximation. Our microscopic results are in good agreement with the empirical data and predictions by Dirac phenomenology.Comment: 16 pages RevTex and 6 figures (paper, available upon request from [email protected]) UI-NTH-931

Capacity Building Impact of the Foundation Programme in Sexual Health Promotion: A Multiple Stakeholder Perspective.

Today, there is widespread agreement that investment in comprehensive sexuality education is critical if as a society we wish to promote sexual health amongst citizens. To this end, in addition to investing in sexual health education, there is an international, national and regional recognition that part of that investment must be in the area of capacity building, which is a key feature of sustainable and effective health promotion. Building capacity increases the range of people, organisations and communities who are able to address health problems, and increases critical problem solving and collaboration within and across organisations, thus multiplying health gains. Similar to international trends, within Ireland the importance of sexual health promotion has been identified as a priority in a number of policy documents and research reports. In addition, there is a move from an issues-driven focus on unintended pregnancy, crisis pregnancy and sexually transmitted infections to a broader multi-sectoral and multidisciplinary concentration on the determinants of sexual health, other forms of sexual health promotion, and sexual health capacity building. However, despite this, there is a limited knowledge base evaluating the outcomes of education and training for those involved in sexual health promotion for capacity building, within both the national and international literature. The focus of this report is the evaluation of the Foundation Programme in Sexual Health Promotion (FPSHP). The FPSHP was developed by staff within the southern region of the Irish Health Service Executive (HSE) in response to an identified need for a more comprehensive programme to develop the sexual health promotion capacity of health, education and community workers in this region. The overall aim of the FPSHP is to enhance participants’ capacity to incorporate sexual health promotion into their work through the development of their comfort levels, confidence, knowledge and skills in relation to sexual health. The programme is comprised of ten days education, with five, two-day sessions spread over four to five months. Between 2009 and the summer of 2012, when the evaluation process began, 12 programmes had been delivered in three HSE South regions. In total, 200 participants completed the programme, drawn from a variety of health, education and social care backgrounds. The evaluation study aimed to: - evaluate the effectiveness of the FPSHP (and its support activities) in building capacity amongst health, education and community professionals with regard to the promotion of sexual health within HSE South; and - establish whether the FPSHP demonstrated sufficient promise in relation to its contribution to sexual health promotion capacity building to warrant a further feasibility study regarding its extension beyond HSE South