Medication Abortion: A Sample Protocol for Increasing Access During a Pandemic and Beyond

No abstrac

Challenges in moderating disruptive player behavior in online competitive action games

Online competitive action games are a very popular form of entertainment. While most are respectfully enjoyed by millions of players, a small group of players engages in disruptive behavior, such as cheating and hate speech. Identifying and subsequently moderating these toxic players is a challenging task. Previous research has only studied specific aspects of this problem using curated data and with limited access to real-world moderation practices. In contrast, our work offers a unique and holistic view of the universal challenges of moderating disruptive behavior in online systems. We combine an analysis of a large dataset from a popular online competitive first-person action title (Call of Duty®: Modern Warfare®II) with insights from stakeholders involved in moderation. We identify six universal challenges related to handling disruptive behaviors in such games. We discuss challenges omitted by prior work, such as handling high-volume imbalanced data or ensuring the comfort of human moderators. We also offer a discussion of possible technical, design, and policy approaches to mitigating these challenges

Breast epithelial cell proliferation is markedly increased with short-term high levels of endogenous estrogen secondary to controlled ovarian hyperstimulation

Oocyte donors have high serum estradiol (E2) levels similar to the serum levels seen in the first trimester of pregnancy. We report in this article our studies comparing cell proliferation, Ki67 (MIB1), and estrogen and progesterone receptor levels (ERα, PRA, and PRB) in the breast terminal duct lobular units of oocyte donors, women in early pregnancy, and in normally cycling women. Breast tissue and blood samples were obtained from 10 oocyte donors, and 30 pregnant women at 5–18 weeks of gestation. Breast tissue samples were also obtained from 26 normally cycling women. In the oocyte donors: peak E2 (mean ~15,300 pmol/l) was reached on the day before oocyte (and tissue) donation; peak progesterone (P4; mean 36.3 nmol/l) was reached on the day of donation; Ki67 was positively associated with level of E2, and the mean Ki67 was 7.0% significantly greater than the mean 1.8% of cycling women. In the pregnant women: mean E2 rose from ~2,000 pmol/l at 5 weeks of gestation to ~27,000 pmol/l at 18 weeks; mean P4 did not change from ~40 nmol/l until around gestational week 11 when it increased to ~80 nmol/l; mean Ki67 was 15.4% and did not vary with gestational age or E2. Oocyte donors have greatly increased levels of E2 and of breast-cell proliferation, both comparable in the majority of donors to the levels seen in the first trimester of pregnancy. Whether their short durations of greatly increased E2 levels are associated with any long-term beneficial effects on the breast, as occurring in rodent models, is not known

Pupil size encodes uncertainty during exploration

Exploration is an important part of decision making and is crucial to maximizing long-term reward. Past work has shown that people use different forms of uncertainty to guide exploration. In this study, we investigate the role of the pupil-linked arousal system in uncertainty-guided exploration. We measured participants’ pupil dilation (N = 48) while they performed a two- armed bandit task. Consistent with previous work, we found that people adopted a hybrid of directed, random and undirected exploration, which are sensitive to relative uncertainty, total uncertainty and value difference between options, respectively. We also found a positive correlation between pupil size and total uncertainty. Furthermore, augmenting the choice model with subject-specific total uncertainty estimates decoded from the pupil size improved predictions of held-out choices, suggesting that people used the uncertainty estimate encoded in pupil size to decide which option to explore Together, the data shed light on the computations underlying uncertainty-driven exploration. Under the assumption that pupil size reflects Locus Coeruleus-Norepinephrine (LC-NE) neuromodulatory activity, these results also extend the theory of LC-NE function in exploration, highlighting its selective role in driving uncertainty- guided random exploration

Medication Abortion: A Sample Protocol for Increasing Access During a Pandemic and Beyond

No abstrac

A dose-finding, cross-over study to evaluate the effect of a Nestorone®/Estradiol transdermal gel delivery on ovulation suppression in normal ovulating women

Objective: This study aims to determine the lowest effective of three Nestorone (NES)/estradiol (E2) transdermal gel doses to ensure ovulation suppression in 90–95% of cycles. Methods: This was a randomized, open-label, three-treatment-period cross-over study to evaluate the effects of NES/E2 transdermal gel on ovulation inhibition, suppression of follicular growth and pharmacokinetic parameters. The doses were low (1.5 mg NES/0.5 mg E2), medium (3.0 mg NES/1.0 mg E2) and high (4.5 mg NES/1.5 mg E2). Participants applied gel daily to a fixed area on the abdomen for 21 consecutive days. They were interviewed regarding their experiences using the gel. Results: Eighteen participants were randomized; 16 completed the study. Median NES Cmax values for low, medium and high dose groups at day 21 were 318.6 pmol/L, 783.0 pmol/L and 1063.8 pmol/L, respectively. Median maximum follicular diameter was higher with the lowest dose with 16.2 mm versus 10.0 and 10.4 mm with the medium and high doses, respectively. Among adherent participants, ovulation was inhibited in all dose groups, except for one participant in the medium dose (6.7%) that had luteal activity and an ultrasound image suggestive of a luteinized unruptured follicle. There were few reports of unscheduled bleeding, with more episodes reported for the lower dose. Adverse events were mild, and no skin irritation was reported from gel application. Conclusion: While all three doses blocked ovulation effectively and were evaluated as safe and acceptable, the medium dose was considered the lowest effective dose based on a more adequate suppression of follicular development. Further development of this novel contraceptive delivering NES and E2 is warranted and has potential for improved safety compared to ethinyl-estradiol-based methods

Data_Sheet_1_Challenges in moderating disruptive player behavior in online competitive action games.pdf

Online competitive action games are a very popular form of entertainment. While most are respectfully enjoyed by millions of players, a small group of players engages in disruptive behavior, such as cheating and hate speech. Identifying and subsequently moderating these toxic players is a challenging task. Previous research has only studied specific aspects of this problem using curated data and with limited access to real-world moderation practices. In contrast, our work offers a unique and holistic view of the universal challenges of moderating disruptive behavior in online systems. We combine an analysis of a large dataset from a popular online competitive first-person action title (Call of Duty®: Modern Warfare®II) with insights from stakeholders involved in moderation. We identify six universal challenges related to handling disruptive behaviors in such games. We discuss challenges omitted by prior work, such as handling high-volume imbalanced data or ensuring the comfort of human moderators. We also offer a discussion of possible technical, design, and policy approaches to mitigating these challenges.</p