Next Generation Philanthropy: Changing the World

The Forbes 400 Summit on Philanthropy, supported by Credit Suisse, brought together 150 of the world's wealthiest and most powerful philanthropists. This subsequent Forbes Insights study was launched to better understand how high net worth individuals across the globe pursue their philanthropic goals. Forbes surveyed 264 high net worth individuals across the globe, including the US, China, Japan, India and the UK

Analysis of Heat Effects on Marine Corps AM2 Mat Mechanical Properties

Navy AM2 mats are used as portable aircraft landing platforms for the Short Take-off/Vertical Landing (STOVL) aircraft operations. This investigation presents the study performed to determine whether the surface discoloration is a precursor to degradation in the mechanical property of the AM2 mat material. The red discoloration on the mat surfaces had a clear correlation with the decrease in yield strength, ultimate strength, and hardness properties

Lipodystrophy, Diabetes and Normal Serum Insulin in PPARγ-Deficient Neonatal Mice

Peroxisome proliferator activated receptor gamma (PPARγ) is a pleiotropic ligand activated transcription factor that acts in several tissues to regulate adipocyte differentiation, lipid metabolism, insulin sensitivity and glucose homeostasis. PPARγ also regulates cardiomyocyte homeostasis and by virtue of its obligate role in placental development is required for embryonic survival. To determine the postnatal functions of PPARγ in vivo we studied globally deficient neonatal mice produced by epiblast-restricted elimination of PPARγ. PPARγ-rescued placentas support development of PPARγ-deficient embryos that are viable and born in near normal numbers. However, PPARγ-deficient neonatal mice show severe lipodystrophy, lipemia, hepatic steatosis with focal hepatitis, relative insulin deficiency and diabetes beginning soon after birth and culminating in failure to thrive and neonatal lethality between 4 and 10 days of age. These abnormalities are not observed with selective PPARγ2 deficiency or with deficiency restricted to hepatocytes, skeletal muscle, adipocytes, cardiomyocytes, endothelium or pancreatic beta cells. These observations suggest important but previously unappreciated functions for PPARγ1 in the neonatal period either alone or in combination with PPARγ2 in lipid metabolism, glucose homeostasis and insulin sensitivity

Narcissism and Stephen Crane’s the monster : a psychoanalytical reading of Dr. Trescott 2014

Stephen Crane’s novella, The Monster, 1 written in 1898, is now often considered one of his best works – but what accounts for that perception? Is it simply due to Crane’s talent as an imagistic author? Although The Monster was Crane’s second novella, the story has generated a vast amount of literary criticism, including dozens of articles highlighting the role of Dr. Trescott. Throughout the years, several critics have suggested that Dr. Trescott exemplifies immense and sincere compassion for Henry Johnson, and, as a result, he becomes a victim to the horrific townspeople of Whilomville. In his article, “Responding to Crane’s ‘The Monster,’ Ronald K. Giles argues that “Thematically considered, ‘The Monster’ is about the consequences of moral courage. Dr. Trescott devotedly cares for Henry Johnson, the man who has saved his son. He treats him, finds a family to take him in, and pays for his keep …. the doctor’s moral victory causes the community to ostracize him” (46;50). Another critic who comes to the doctor’s defense is Sy Kahn who argues that the townspeople are “monstrous” for “their terror and eventual persecution of Dr. Trescott” (37). While such suggestions seem to hold some validity on the surface, when we delve deeper into the psyche of Dr. Trescott, we begin to realize the true motive behind his “sincere compassion”; furthermore, explicating Crane’s specific use of language decenters the dominant view of Trescott’s genuine acts of kindness. Although there is no concrete evidence that Dr. Trescott suffers from any sort of diagnosed disorder, there are various incidents throughout the story which suggest that he is affected by a personality disorder known as Narcissistic Personality Disorder (NPD)

Targeting the post-synaptic proteome has therapeutic potential for psychosis in Alzheimer Disease

Abstract Individuals with Alzheimer Disease who develop psychotic symptoms (AD + P) experience more rapid cognitive decline and have reduced indices of synaptic integrity relative to those without psychosis (AD-P). We sought to determine whether the postsynaptic density (PSD) proteome is altered in AD + P relative to AD-P, analyzing PSDs from dorsolateral prefrontal cortex of AD + P, AD-P, and a reference group of cognitively normal elderly subjects. The PSD proteome of AD + P showed a global shift towards lower levels of all proteins relative to AD-P, enriched for kinases, proteins regulating Rho GTPases, and other regulators of the actin cytoskeleton. We computationally identified potential novel therapies predicted to reverse the PSD protein signature of AD + P. Five days of administration of one of these drugs, the C-C Motif Chemokine Receptor 5 inhibitor, maraviroc, led to a net reversal of the PSD protein signature in adult mice, nominating it as a novel potential treatment for AD + P