Theory of Combined Photoassociation and Feshbach Resonances in a Bose-Einstein Condensate

We model combined photoassociation and Feshbach resonances in a Bose-Einstein condensate, where the shared dissociation continuum allows for quantum interference in losses from the condensate, as well as a dispersive-like shift of resonance. A simple analytical model, based on the limit of weakly bound molecules, agrees well with numerical experiments that explicitly include dissociation to noncondensate modes. For a resonant laser and an off-resonant magnetic field, constructive interference enables saturation of the photoassociation rate at user-friendly intensities, at a value set by the interparticle distance. This rate limit is larger for smaller condensate densities and, near the Feshbach resonance, approaches the rate limit for magnetoassociation alone. Also, we find agreement with the unitary limit--set by the condensate size--only for a limited range of near-resonant magnetic fields. Finally, for a resonant magnetic field and an off-resonant laser, magnetoassociation displays similar quantum interference and a dispersive-like shift. Unlike photoassociation, interference and the fieldshift in resonant magnetoassociation is tunable with both laser intensity and detuning. Also, the dispersive-like shift of the Feshbach resonance depends on the size of the Feshbach molecule, and is a signature of non-universal physics in a strongly interacting system.Comment: 10 pages, 5 figures, 82 reference

Growth Motivation and Well-Being in the U.S., Japan, Guatemala, and India

The present study examined how the Growth Motivation Index (GMI; J. J. Bauer et al., 2015) related to well-being and identity exploration in samples from the U.S., Japan, Guatemala, and India. The GMI has two facets. GMI-reflective measures the motive to cultivate critical self-reflection and intellectual development, whereas GMI-experiential measures the motive to cultivate personally meaningful activities and relationships. We expected and found that, when comparing the two GMI facets simultaneously, GMI-reflective predicted well-being in countries ranked as having collectivist but not individualist cultures, whereas GMI-experiential predicted well-being in countries ranked as having individualist but not collectivist cultures. GMI-reflective predicted identity exploration across cultures. Implications for growth motivation and culture are discussed

The expanding phenotype of OFD1-related disorders: Hemizygous loss-of-function variants in three patients with primary ciliary dyskinesia

Background: OFD1 has long been recognized as the gene implicated in the classic dysmorphology syndrome, oral-facial-digital syndrome type I (OFDSI). Over time, pathogenic variants in OFD1 were found to be associated with X-linked intellectual disability, Joubert syndrome type 10 (JBTS10), Simpson-Golabi-Behmel syndrome type 2 (SGBS2), and retinitis pigmentosa. Recently, OFD1 pathogenic variants have been implicated in primary ciliary dyskinesia (PCD), a disorder of the motile cilia with a phenotype that includes recurrent oto-sino-pulmonary infections, situs abnormalities, and decreased fertility. Methods: We describe three male patients with PCD who were found to have hemizygous pathogenic variants in OFD1, further supporting that PCD is part of a clinical spectrum of OFD1-related disorders. In addition, we provide a review of the available clinical literature describing patients with OFD1 variants and highlight the phenotypic variability of OFD1-related disease. Results: Some individuals with hemizygous OFD1 variants have PCD, either apparently isolated or in combination with other features of OFD1-related disorders. Conclusion: As clinicians consider the presence or absence of conditions allelic at OFD1, PCD should be considered part of the spectrum of OFD1-related disorders. Understanding the OFD1-related disease spectrum may allow for more focused genetic testing and more timely management of treatable sequelae

Development of a validated patient-reported symptom metric for pediatric Eosinophilic Esophagitis: qualitative methods

<p>Abstract</p> <p>Background</p> <p>Previous attempts to measure symptoms in pediatric Eosinophilic Esophagitis (EoE) have not fully included patients and parents in the item development process. We sought to identify and validate key patient self-reported and parent proxy-reported outcomes (PROs) specific to EoE.</p> <p>Methods</p> <p>We developed methodology for focus and cognitive interviews based on the Food and Drug Administration (FDA) guidelines for PROs, the validated generic PedsQL™ guidelines, and the consolidated criteria for reporting qualitative research (COREQ). Both child (ages 8-12 and 13-18) and parent-proxy (ages 2-4, 5-7, 8-12, and 13-18) interviews were conducted.</p> <p>Results</p> <p>We conducted 75 interviews to construct the new instrument. Items were identified and developed from individual focus interviews, followed by cognitive interviews for face and content validation. Initial domains of symptom frequency and severity were developed, and open-ended questions were used to generate specific items during the focus interviews. Once developed, the instrument construct, instructions, timeframe, scoring, and specific items were systematically reviewed with a separate group of patients and their parents during the cognitive interviews.</p> <p>Conclusions</p> <p>To capture the full impact of pediatric EoE, both histologic findings and PROs need to be included as equally important outcome measures. We have developed the face and content validated Pediatric Eosinophilic Esophagitis Symptom Score (PEESS™ v2.0). The PEESS™ v2.0 metric is now undergoing multisite national field testing as the next iterative instrument development phase.</p