16 research outputs found

    Exogenous and endogenous secretin stimulation in the conscious rat

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    The actions of intravenous secretin injection and of intraduodenal acid infusion were studied in conscious rats who had recovered from the operative procedure and were maintained at a normal body temperature. The basal secretion calculated per unit weight of pancreas was higher in the rat than in the dog, even when the basal endogenous secretin stimulation induced by gastric acid was suppressed by ligation of the pylorus. Intravenous injection of GIH secretin induced a doserelated increase in volume and bicarbonate outputs. A brief washing out of proteins occurred initially. The maximal secretory response to endogenous stimulation was less than after intravenous secretin injection. The rate of secretin release was the limiting factor of the endogenously stimulated secretion. Calculated per unit weight of gland, the maximal secretory response of the pancreas to secretin is smaller in the rat than in the dog. © 1974 by S. Karger AG, Basel.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

    Non-parallel secretion of pancreatic enzymes. Effect of parenteral amino acid administration and intestinal reinfusion of bilio-pancreatic juice

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    Chronic drainage of pancreatic juice in rats results in a non-parallel secretion of digestive enzymes. The concentration of trypsinogen, chymotrypsinogen, procarboxypeptidase B and lipase increases continuously whereas that of amylase drops. An amino acid mixture given intravenously does not affect this dissociation. Reinfusion of bilio-pancreatic juice into the duodenum on the contrary influences the relative enzyme release: the increase in concentration of the three proteolytic enzymes and of lipase is less pronounced over the 72-hour study period; amylase concentration remains unaffected. In the absence of an intravenous amino acid feeding the pancreatic protein output is more than halved and a negative nitrogen balance is observed. Reinfusion of bilio-pancreatic juice does not alter the total protein output. This report confirms the persistence of a dissociation in the rate of enzyme release in rats with chronic pancreatic fistula despite sufficient protein administration and intestinal reintroduction of bilio-pancreatic juice.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

    Enterobius vermicularis Infection with tuboovarian abscess and peritonitis occurring during pregnancy

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    Background: Extraintestinal Enterobius vermicularis infections are rare but may occasionally affect the female genital tract. Although mostly asymptomatic or causing minor clinical problems, they may lead to severe infectious complications. Methods: Case report and review of the pertinent English language literature. Results: A 31-year-old, 30-week-pregnant female was admitted with a clinical suspicion of appendicitis. At surgery, the appendix appeared normal, but generalized peritonitis of unclear origin was present. Eggs of Enterobius vermicularis were found upon microbiological and pathological examination. Because of persisting infectious disease, the patient underwent an elective caesarean section, and at that time the diagnosis of a right tuboovarian abscess was made, and salpingo-oophorectomy was performed. The pathology report confirmed the diagnosis of an E. vermicularis salpingo-oophoritis. Conclusion: This case was extraordinary because of a combination of tuboovarian abscess and generalized peritonitis with E. vermicularis infection occurring during late pregnancy. Ectopic enterobiasis should be considered in the differential diagnosis of pelvic infections of gynecological origin

    Clinical relevance of laparoscopically diagnosed hiatal hernia

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    To determine the clinical relevance of a laparoscopically diagnosed hiatal hernia. Consecutive patients undergoing an elective laparoscopy were prospectively recruited. We assessed preoperative gastroesophageal reflux symptoms using a validated score, and documented the presence or absence of a hiatal hernia during laparoscopy. Of the 95 evaluable patients, 42 (44%) had a hiatal hernia. The mean age was 49.8 years. Logistic regression analysis indicated that three features were significantly and independently associated with hiatal hernia: a higher reflux score (odds ratio [OR] 2.44; 95% confidence interval [CI] 1.48-4.05; p < 0.001), low body mass index (BMI) (OR 0.83; 95% CI 0.70-0.98; p = 0.029), and type of surgery (OR 0.34; 95% CI 0.14-0.92; p = 0.033). The diagnostic accuracy of a reflux score of more than 2 was 81%, with a sensitivity, specificity, positive predictive value, and negative predictive value of 76%, 85%, 80%, and 82%, respectively. The likelihood ratio for a positive result was 5.05. Hiatal hernia is common in this population of surgical patients undergoing an elective laparoscopy. Patients with reflux symptoms or a low BMI were more likely to have a hiatal hernia. With a reflux score of more than 2, the probability of finding a hiatal hernia during laparoscopy is 80%
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