Function of the Endolysosomal Network in Cholesterol Homeostasis and Metabolic Associated Fatty Liver Disease (MAFLD)

BACKGROUND: Metabolic associated fatty liver disease (MAFLD), also known as non-alcoholic fatty liver disease, has become the leading cause of chronic liver disease worldwide. Besides hepatic accumulation of triglycerides, dysregulated cholesterol metabolism is an important contributor to the pathogenesis of MAFLD. Maintenance of cholesterol homeostasis is highly dependent on cellular cholesterol uptake, and subsequently cholesterol transport to other membrane compartments, such as the endocytic reticulum (ER). SCOPE OF REVIEW: The endolysosomal network is key for regulating cellular homeostasis and adaptation, and emerging evidence has shown that the endolysosomal network is crucial to maintain metabolic homeostasis. In this review, we will summarize our current understanding of the role of the endolysosomal network in cholesterol homeostasis and its implications in MAFLD pathogenesis. MAJOR CONCLUSIONS: Although multiple endolysosomal proteins have been identified in the regulation of cholesterol uptake, intracellular transport, and degradation, their physiological role is incompletely understood. Further research should elucidate their role in controlling metabolic homeostasis and development of fatty liver disease

Exploring the relationship between the COVID-19 pandemic and changes in travel behaviour: A qualitative study

During the COVID-19 crisis, a series of measures were taken to restrict travel and social activities outside the home in order to curb the pandemic and ameliorate its negative effects. These unprecedented measures have had a profound impact on the number and purposes of trips and modes of travel. In China, although the pandemic is now generally under control and transport availability has returned to nearly normal, the extent of the changes in travel behaviour wrought during and after the pandemic still remains unclear. Therefore, the aim of this paper is to investigate the differences in individual travel behaviours during and after the COVID-19 pandemic, using Huzhou as an example. Semi-structured interviews were used to examine the influence of COVID-19 on the travel behaviour and perceptions of different groups. The results indicate that, initially, travel demand was greatly reduced. Second, decreased travel reduced participation in activities, which can have adverse effects on people’s health as well as their subjective well-being. Third, the degree and duration of such impacts varied from person to person. Students, lower income cohorts, groups living in small communities with insufficient green spaces, and those working in tourism, catering, informal businesses and transport-related sectors were more vulnerable than others. Policymakers, urban and transport planners should therefore pay attention to the social inequities that arise from unequal access to transport and heterogeneity between individuals. Additionally, public transport systems require further development to promote social cohesion

Cosmic rays studied with a hybrid high school detector array

The LORUN/NAHSA system is a pathfinder for hybrid cosmic ray research combined with education and outreach in the field of astro-particle physics. Particle detectors and radio antennae were mainly setup by students and placed on public buildings. After fully digital data acquisition, coincidence detections were selected. Three candidate events confirmed a working prototype, which can be multiplied to extend further particle detector arrays on high schools.Comment: 10 pages, 6 figures. Nigl, A., Timmermans, C., Schellart, P., Kuijpers, J., Falcke, H., Horneffer, A., de Vos, C. M., Koopman, Y., Pepping, H. J., Schoonderbeek, G., Cosmic rays studied with a hybrid high school detector array, Europhysics News (EPN), Vol. 38, No. 5, accepted on 22/08/200

The influence of the built environment on online purchases of intangible services: Examining the mediating role of online purchase attitudes

Via the internet, people can easily access high quantities of (information on) intangible services (e.g., dining out services, movie theater visits), often at low(er) prices. Therefore, purchasing these services online likely stimulates consumers to make extra trips for on-site consumption, thus posing a possible challenge for transportation systems. Meanwhile, attitudes toward online purchases may vary by the built environment. People in non-urban areas (compared to those in urban areas) may benefit more from online purchases due to lower accessibility to physical purchase opportunities. Therefore, they may have more positive attitudes toward online purchases and thus purchase more online. In this study, we analyze the effects of the built environment on online purchases – considering the potential mediating effects of attitudes – in order to clarify whether implementing built environment interventions is effective to cope with this transportation challenge. Using data acquired from 717 interviews in Beijing, China in 2015, a Structural Equation Modeling analysis indicates that higher employment density, lower accessibility to metro stations, and lower street density have direct and positive effects on online buying of intangible services. Additionally, higher accessibility to shopping centers has an indirect and adverse effect on online buying behavior through attitudes toward online buying. Therefore, implementing built environment interventions might be valid to moderate travel demands resulting from online purchases of intangible services

Akkermansia muciniphila in the Human Gastrointestinal Tract: When, Where, and How?

Akkermansia muciniphila is a mucin-degrading bacterium of the phylum Verrucomicrobia. Its abundance in the human intestinal tract is inversely correlated to several disease states. A. muciniphila resides in the mucus layer of the large intestine, where it is involved in maintaining intestinal integrity. We explore the presence of Akkermansia-like spp. based on its 16S rRNA sequence and metagenomic signatures in the human body so as to understand its colonization pattern in time and space. A. muciniphila signatures were detected in colonic samples as early as a few weeks after birth and likely could be maintained throughout life. The sites where Akkermansia-like sequences (including Verrucomicrobia phylum and/or Akkermansia spp. sequences found in the literature) were detected apart from the colon included human milk, the oral cavity, the pancreas, the biliary system, the small intestine, and the appendix. The function of Akkermansia-like spp. in these sites may differ from that in the mucosal layer of the colon. A. muciniphila present in the appendix or in human milk could play a role in the re-colonization of the colon or breast-fed infants, respectively. In conclusion, even though A. muciniphila is most abundantly present in the colon, the presence of Akkermansia-like spp. along the digestive tract indicates that this bacterium might have more functions than those currently known.Peer reviewe

A first phase in the habitat classification for the Zeeschelde: Bed form classification

Within the scope of the long term vision of the Schelde Estuary and the Development Outline 2010 low dynamic intertidal and shallow water areas are considered to be of high ecological value. Little is known about the occurrence of such valuable reas in the Schelde Estuary, nor are the physical and morphological processes which determine the occurrence of these areas fully understood. Based on the results and recommendations of a 2008-2009 research project in the Westerschelde, a new research project was defined to determine relationships between abiotic (bedforms, hydrodynamics, sediment) and biotic (benthos) characteristics in the Zeeschelde (Belgium) and to set up a classification of deep and undeep subtidal areas. A first phase in the habitat classification comprises of the analysis of bed form occurrence and the setup of a bed form classification based on multibeam echo sounding data. Results show within the different sub areas a variation in bed forms going from hard bed layers to no bed forms to ripples (H ~ 0,1 to 0,3 m | L ~ 10 m) and smaller dunes (H ~ 0,5 to 1 m | L ~ 15 to 25 m). On-going research investigates relationships between the bed form characteristics and flow and sediment characteristics. Preliminary results

On Statistical Analysis of Brain Variability.

We discuss what we believe could be an improvement in future discussions of the ever-changing brain. We do so by distinguishing different types of brain variability and outlining methods suitable to analyse them. We argue that, when studying brain and behaviour data, classical methods such as regression analysis and more advanced approaches both aim to decompose the total variance into sensible variance components. In parallel, we argue that a distinction needs to be made between innate and acquired brain variability. For varying high-dimensional brain data, we present methods useful to extract their low-dimensional representations. Finally, to trace potential causes and predict plausible consequences of brain variability, we discuss how to combine statistical principles and neurobiological insights to make associative, explanatory, predictive, and causal enquires; but cautions are needed to raise association- or prediction-based neurobiological findings to causal claims