A superconducting absolute spin valve

A superconductor with a spin-split excitation spectrum behaves as an ideal ferromagnetic spin-injector in a tunneling junction. It was theoretical predicted that the combination of two such spin-split superconductors with independently tunable magnetizations, may be used as an ideal $absolute$ spin-valve. Here we report on the first switchable superconducting spin-valve based on two EuS/Al bilayers coupled through an aluminum oxide tunnel barrier. The spin-valve shows a relative resistance change between the parallel and antiparallel configuration of the EuS layers up to 900% that demonstrates a highly spin-polarized currents through the junction. Our device may be pivotal for realization of thermoelectric radiation detectors, logical element for a memory cell in cryogenics superconductor-based computers and superconducting spintronics in general.Comment: 6 pages, 4 color figures, 1 tabl

Revealing the magnetic proximity effect in EuS/Al bilayers through superconducting tunneling spectroscopy

A ferromagnetic insulator attached to a superconductor is known to induce an exchange splitting of the Bardeen-Cooper-Schrieffer (BCS) singularity by a magnitude proportional to the magnetization, and penetrating into the superconductor to a depth comparable with the superconducting coherence length. We study this long-range magnetic proximity effect in EuS/Al bilayers and find that the exchange splitting of the BCS peaks is present already in the unpolarized state of the ferromagnetic insulator (EuS), and is being further enhanced when magnetizing the sample by a magnetic field. The measurement data taken at the lowest temperatures feature a high contrast which has allowed us to relate the line shape of the split BCS conductance peaks to the characteristic magnetic domain structure of the EuS layer in the unpolarized state. These results pave the way to engineering triplet superconducting correlations at domain walls in EuS/Al bilayers. Furthermore, the hard gap and clear splitting observed in our tunneling spectroscopy measurements indicate that EuS/Al bilayers are excellent candidates for substituting strong magnetic fields in experiments studying Majorana bound states.Comment: 9 pages, 4 color figure

Optical supercavitation in soft-matter

We investigate theoretically, numerically and experimentally nonlinear optical waves in an absorbing out-of-equilibrium colloidal material at the gelification transition. At sufficiently high optical intensity, absorption is frustrated and light propagates into the medium. The process is mediated by the formation of a matter-shock wave due to optically induced thermodiffusion, and largely resembles the mechanism of hydrodynamical supercavitation, as it is accompanied by a dynamic phase-transition region between the beam and the absorbing material.Comment: 4 pages, 5 figures, revised version: corrected typos and reference

Elasto-viscoplastic modeling of subsidence above gas fields in the Adriatic Sea

Abstract. From the analysis of GPS monitoring data collected above gas fields in the Adriatic Sea, in a few cases subsidence responses have been observed not to directly correlate with the production trend. Such behavior, already described in the literature, may be due to several physical phenomena, ranging from simple delayed aquifer depletion to a much more complex time-dependent mechanical response of subsurface geomaterials to fluid withdrawal. In order to accurately reproduce it and therefore to be able to provide reliable forecasts, in the last years Eni has enriched its 3D finite element geomechanical modeling workflow by adopting an advanced constitutive model (Vermeer and Neher, 1999), which also considers the viscous component of the deformation. While the numerical implementation of such methodology has already been validated at laboratory scale and tested on synthetic hydrocarbon fields, the work herein presents its first application to a real gas field in the Adriatic Sea where the phenomenon has been observed. The results show that the model is capable to reproduce very accurately both GPS data and other available measurements. It is worth remarking that initial runs, characterized by the use of model parameter values directly obtained from the interpretation of mechanical laboratory tests, already provided very good results and only minor tuning operations have been required to perfect the model outcomes. Ongoing R&D projects are focused on a regional scale characterization of the Adriatic Sea basin in the framework of the Vermeer and Neher model approach

Characterisation of the secondary-neutron production in particle therapy treatments with the MONDO tracking detector

Particle Therapy (PT) is a non-invasive technique that exploits charged light ions for the irradiation of tumours that cannot be effectively treated with surgery or conventional radiotherapy. While the largest dose fraction is released to the tumour volume by the primary beam, a non-negligible amount of additional dose is due to the beam fragmentation that occurs along the path towards the target volume. In particular, the produced neutrons are particularly dangerous as they can release their energy far away from the treated area, increasing the risk of developing a radiogenic secondary malignant neoplasm after undergoing a treatment. A precise measurement of the neutron flux, energy spectrum and angular distributions is eagerly needed in order to improve the treatment planning system software, so as to predict the normal tissue toxicity in the target region and the risk of late complications in the whole body. The MONDO (MOnitor for Neutron Dose in hadrOntherapy) project is dedicated to the characterisation of the secondary ultra-fast neutrons ([20-400] MeV energy range) produced in PT. The neutron tracking system exploits the reconstruction of the recoil protons produced in two consecutive (n, p) elastic scattering interactions to measure simultaneously the neutron incoming direction and energy. The tracker active media is a matrix of thin squared scintillating fibers arranged in orthogonally oriented layers that are read out by a sensor (SBAM) based on SPAD (Single-Photon Avalanche Diode) detectors developed in collaboration with the Fondazione Bruno Kessler (FBK)

In-room test results at CNAO of an innovative PT treatments online monitor (Dose Profiler)

The use of C, He and O ions as projectiles in Particle Therapy (PT) treatments is getting more and more widespread as a consequence of their enhanced relative biological effectiveness and oxygen enhancement ratio, when compared to the protons one. The advantages related to the incoming radiation improved efficacy are requiring an accurate online monitor of the dose release spatial distribution. Such monitor is necessary to prevent unwanted damage to the tissues surrounding the tumour that can arise, for example, due to morphological changes occurred in the patient during the treatment with respect to the initial CT scan. PT treatments with ions can be monitored by detecting the secondary radiation produced by the primary beam interactions with the patient body along the path towards the target volume. Charged fragments produced in the nuclear process of projectile fragmentation can be emitted at large angles with respect to the incoming beam direction and can be detected with high efficiency in a nearly background-free environment. The Dose Profiler (DP) detector, developed within the INSIDE project, is a scintillating fibre tracker that allows an online reconstruction and backtracking of such secondary charged fragments. The construction and preliminary in-room tests performed on the DP, carried out using the 12C ions beam of the CNAO treatment centre using an anthropomorphic phantom as a target, will be reviewed in this contribution. The impact of the secondary fragments interactions with the patient body will be discussed in view of a clinical application. Furthermore, the results implications for a pre-clinical trial on CNAO patients, foreseen in 2019, will be discussed

Effects of Upstream Wakes on the Boundary Layer Over a Low-Pressure Turbine Blade

In the present work, the evolution of the boundary layer over a low-pressure turbine blade is studied using direct numerical simulations, with the aim of investigating the unsteady flow field induced by the rotor-stator interaction. The freestream flow is characterized by the high level of freestream turbulence and periodically impinging wakes. As in the experiments, the wakes are shed by moving bars modeling the rotor blades and placed upstream of the turbine blades. To include the presence of the wake without employing an ad-hoc model, we simulate both the moving bars and the stationary blades in their respective frames of reference and the coupling of the two domains is done through appropriate boundary conditions. The presence of the wake mainly affects the development of the boundary layer on the suction side of the blade. In particular, the flow separation in the rear part of the blade is suppressed. Moreover, the presence of the wake introduces alternating regions in the streamwise direction of high- and low-velocity fluctuations inside the boundary layer. These fluctuations are responsible for significant variations of the shear stress. The analysis of the velocity fields allows the characterization of the streaky structures forced in the boundary layer by turbulence carried by upstream wakes. The breakdown events are observed once positive streamwise velocity fluctuations reach the end of the blade. Both the fluctuations induced by the migration of the wake in the blade passage and the presence of the streaks contribute to high values of the disturbance velocity inside the boundary layer with respect to a steady inflow case. The amplification of the boundary layer disturbances associated with different spanwise wavenumbers has been computed. It was found that the migration of the wake in the blade passage stands for the most part of the perturbations with zero spanwise wavenumber. The non-zero wavenumbers are found to be amplified in the rear part of the blade at the boundary between the lowand high-speed regions associated with the wakes. [DOI: 10.1115/1.4056108

Electronic reminders and rewards to improve adherence to inhaled asthma treatment in adolescents: a non-randomised feasibility study in tertiary care

OBJECTIVE: To test the feasibility and acceptability of a short-term reminder and incentives intervention in adolescents with low adherence to asthma medications. METHODS: Mixed-methods feasibility study in a tertiary care clinic. Adolescents recruited to a 24-week programme with three 8-weekly visits, receiving electronic reminders to prompt inhaled corticosteroid (ICS) inhalation through a mobile app coupled with electronic monitoring devices (EMD). From the second visit, monetary incentives based on adherence of ICS inhalation: £1 per dose, maximum £2 /day, up to £112/study, collected as gift cards at the third visit. End of study interviews and questionnaires assessing perceptions of asthma and ICS, analysed using the Perceptions and Practicalities Framework. PARTICIPANTS: Adolescents (11-18 years) with documented low ICS adherence (<80% by EMD), and poor asthma control at the first clinic visit. RESULTS: 10 out of 12 adolescents approached were recruited (7 males, 3 females, 12-16 years). Eight participants provided adherence measures up to the fourth visits and received rewards. Mean study duration was 281 days, with 7/10 participants unable to attend their fourth visit due to COVID-19 lockdown. Only 3/10 participants managed to pair the app/EMD up to the fourth visit, which was associated with improved ICS adherence (from 0.51, SD 0.07 to 0.86, SD 0.05). Adherence did not change in adolescents unable to pair the app/EMD. The intervention was acceptable to participants and parents/guardians. Exit interviews showed that participants welcomed reminders and incentives, though expressed frustration with app/EMD technological difficulties. Participants stated the intervention helped through reminding ICS doses, promoting self-monitoring and increasing motivation to take inhalers. CONCLUSIONS: An intervention using electronic reminders and incentives through an app coupled with an EMD was feasible and acceptable to adolescents with asthma. A pilot randomised controlled trial is warranted to better estimate the effect size on adherence, with improved technical support for the EMD

Barriers and facilitators to adherence to secondary stroke prevention medications after stroke: Analysis of survivors’ and caregivers’ views from an online stroke forum

$\textbf{Objective:}$ To identify barriers and facilitators of medication adherence in patients with stroke along with their caregivers. DESIGN: Qualitative thematic analysis of posts about secondary prevention medications, informed by Perceptions and Practicalities Approach. $\textbf{Setting:}$ Posts written by the UK stroke survivors and their family members taking part in the online forum of the Stroke Association, between 2004 and 2011. $\textbf{Participants:}$ 84 participants: 49 stroke survivors, 33 caregivers, 2 not stated, identified using the keywords 'taking medication', 'pills', 'size', 'side-effects', 'routine', 'blister' as well as secondary prevention medication terms. $\textbf{Results:}$ Perceptions reducing the motivation to adhere included dealing with medication side effects, questioning doctors' prescribing practices and negative publicity about medications, especially in regard to statins. Caregivers faced difficulties with ensuring medications were taken while respecting the patient's decisions not to take tablets. They struggled in their role as advocates of patient's needs with healthcare professionals. Not experiencing side effects, attributing importance to medications, positive personal experiences of taking tablets and obtaining modification of treatment to manage side effects were facilitators of adherence. Key practical barriers included difficulties with swallowing tablets, dealing with the burden of treatment and drug cost. Using medication storage devices, following routines and getting help with medications from caregivers were important facilitators of adherence. $\textbf{Conclusions:}$ An online stroke forum is a novel and valuable resource to investigate use of secondary prevention medications. Analysis of this forum highlighted significant barriers and facilitators of medication adherence faced by stroke survivors and their caregivers. Addressing perceptual and practical barriers highlighted here can inform the development of future interventions aimed at improving adherence to secondary prevention medication after stroke.DS is funded by a National Institute for Health Research (NIHR) Academic Clinical Lectureship. JJ was supported by a research grant from The Stroke Association and the British Heart Foundation

Effects of treatment for acromegaly on Bone Mineral Density (BMD): is Pegvisomant protective on lumbar BMD?

The abstract deals with the different effects of treatments for acromegaly on bon