Kaon physics with the KLOE detector

In this paper we discuss the recent finalized analyses by the KLOE experiment at DA$\Phi$NE: the CPT and Lorentz invariance test with entangled $K^0 \bar{K}^0$ pairs, and the precision measurement of the branching fraction of the decay ${ K^+} \rightarrow \pi^+\pi^-\pi^+(\gamma)$. We also present the status of an ongoing analysis aiming to precisely measure the $K^{\pm}$ mass

Modelling of the carburizing and nitriding processes

The thermo-chemical diffusion process of carburizing and nitriding was modeled in the present study. The analyses led to the prediction of surface hardened layers dimensions and hardness in commercial steels. A diffusion model based on Fick’s laws was applied to such steels in order to describe the growth kinetics of layers, then the analytical model was employed to perform finite element calculations. In such a way it was possible to calculate the carbon and nitrogen concentration in the cross sections of cylindrical samples and the consequent hardness profiles coupled with those of the residual stresses. The results from analytical model and FE calculations were compared with experimental data

Evaluating the expression of urokinase and tissue leukocyte being in benign and malignant breast disease

Introduction: Our objectives is to show that the expression of uPA leukocyte could be considered, in the future, as a marker of the expression of uPA in the malignant tissue and therefore a potential indicator of prognosis. Methods: We examined the expression of uPa in leukocytes and tissues of three groups of women: with breast cancer; with benign breast lesion and healthy women (control group). We used RT Real Time PCR assay. The expression of urokinase is significantly higher in malignant breast lumps compared to benign lesions. However, in women with carcinoma of the breast, malignant tissue expresses higher amounts of uPA than the healthy counterpart. There are no statistically significant differences in the expression of uPA, between tissues taken from women with benign lesions. The lymphocytes taken from healthy volunteers show a level of expression of uPA significantly lower than the other tested samples Lymphocytes extracted from cancer patients express higher amounts of uPA compared to lymphocytes belonging to women with benign breast lesions. The expression of uPA was compared with the clinical and biological parameters commonly used in clinical practice for the definition of the prognosis. The only exception found, concerns those tumors characterized by the simultaneous negativity for estrogen receptors, progesterone and HER2 (state of triple negative), in which the expression of uPA is very high. Results and conclusions: Our data show that uPA expressed by leukocytes of each individual patient is the mirror image of the one expressed by malignant nodular uPA.Introduction: Our objectives is to show that the expression of uPA leukocyte could be considered, in the future, as a marker of the expression of uPA in the malignant tissue and therefore a potential indicator of prognosis. Methods: We examined the expression of uPa in leukocytes and tissues of three groups of women: with breast cancer; with benign breast lesion and healthy women (control group). We used RT Real Time PCR assay. The expression of urokinase is significantly higher in malignant breast lumps compared to benign lesions. However, in women with carcinoma of the breast, malignant tissue expresses higher amounts of uPA than the healthy counterpart. There are no statistically significant differences in the expression of uPA, between tissues taken from women with benign lesions. The lymphocytes taken from healthy volunteers show a level of expression of uPA significantly lower than the other tested samples Lymphocytes extracted from cancer patients express higher amounts of uPA compared to lymphocytes belonging to women with benign breast lesions. The expression of uPA was compared with the clinical and biological parameters commonly used in clinical practice for the definition of the prognosis. The only exception found, concerns those tumors characterized by the simultaneous negativity for estrogen receptors, progesterone and HER2 (state of triple negative), in which the expression of uPA is very high. Results and conclusions: Our data show that uPA expressed by leukocytes of each individual patient is the mirror image of the one expressed by malignant nodular uPA

One-step replica symmetry breaking solution of the quadrupolar glass model

We consider the quadrupolar glass model with infinite-range random interaction. Introducing a simple one-step replica symmetry breaking ansatz we investigate the para-glass continuous (discontinuous) transition which occurs below (above) a critical value of the quadrupole dimension m*. By using a mean-field approximation we study the stability of the one-step replica symmetry breaking solution and show that for m>m* there are two transitions. The thermodynamic transition is discontinuous but there is no latent heat. At a higher temperature we find the dynamical or glass transition temperature and the corresponding discontinuous jump of the order parameter.Comment: 10 pages, 3 figure

Effect of anisotropy on Fatigue properties of AA2198 Al-Li plates joined by Friction Stir Welding

Al-Li alloys are characterized by a strong anisotropy in mechanical and microstructural properties with respect to the rolling direction. In the present paper sheets, 4 mm thick, of AA2198 Al-Li alloy were joined via Friction Stir Welding (FSW) by employing a rotating speed of 1000 RPM and a welding speed of 80 mm/min, in parallel and orthogonal direction with respect to the rolling one. The joint mechanical properties were evaluated by means of tensile tests at room temperature. In addition, fatigue tests were performed by using a resonant electro-mechanical testing machine under constant amplitude control up to 250 Hz sinusoidal loading. The fatigue tests were conducted in axial control mode with R=?min/?max=0.33, for all the welding and rotating speeds conditions. The damage behavior was studied by applying thermoelastic stress analysis (TSA) to the crack formation and propagation of friction stir welded sheets under cyclic fatigue tests. The fatigue crack propagation experiments were performed on single edge notched specimens. Fatigue tests were carried out up to failure in tension- tension with load ratio R=0.33. The TSA measurement system allowed crack evolution to be observed in real-time during fatigue cycles and stress fields to be derived on the specimens from the temperature variation. The thermoelastic data were used to measure the principal stresses and principal strains on the specimens surface and the crack growth rate during tests. All the results were validated by employing finite element analysis performed with ABAQUS software. SEM observations of the fractured surfaces were done to characterize the weld performances

A geobotanical survey on acidophilous grasslands in the Abruzzo, Lazio and Molise National Park (Central Italy)

The acidophilous grasslands of the south-eastern part of the Abruzzo, Lazio and Molise National Park was studied by the phytosociological method and analyzed from a synecological viewpoint with the help of soil analysis. Four clusters of relevés resulted from the numerical classification. Syntaxonomically they were ascribed to the following associations: Poo violaceae-Nardetum strictae, Potentillo rigoanae-Festucetum paniculatae, Nardo strictae-Brachypodietum genuensis and Potentillo rigoanae-Brachypodietum genuensis. Since the original proposal of all the syntaxa identified in the present study were affected by nomenclatural mistakes, they were corrected in accordance with the rules of ICPN. The occurrence of Anthoxanto-Brachypodietum in central Apennines, is excluded since this association falls in syntaxonomical synonymy with Potentillo-Brachypodietum. The synecological analysis proved that the distribution of the different communities identified within the study area to be correlated with topographic, geomorphological and soil factors. Among these latter, the ratio H+/basic cations, pH behave as the most influencing parameters in the distribution of the communities identified

Which is the most accurate diagnostic procedure in Tamoxifen treated breast cancer patients

Purpose: The aim of this study was to evaluate the diagnostic accuracy of bi-dimensional (2D) and three-dimensional (3D) transvaginal ultrasound (TVUS), hysterosonography (HSSG) and hysteroscopy in the detection of endometrial pathology in women treated with tamoxifen (TMX) for breast cancer. Methods: Forty-two patients, affected by breast cancer under treatment with TMX, underwent 2D-3D TVUS, HSSG and hysteroscopy completed by biopsy, after abnormal findings following a routine 2D TVUS examination. Results: 3D-TVUS was more accurate than 2D-TVUS in the detection of atrophic endometrium confirmed by biopsy and in the detection of endometrial polyps. HSSG and hysteroscopy detected atrophic endometrium and endometrial polyps significantly better than ultrasound scan. Endometrial carcinoma was detected in two cases, and in both HSSG and hysteroscopy were 100% diagnostic. Conclusion: In TMX treated breast cancer patients, HSSG and hysteroscopy provide more accurate diagnosis than 2D-3D ultrasound in the detection of treatment related endometrial lesions

Differences in gluten protein composition between old and modern durum wheat genotypes in relation to 20th century breeding in Italy

The impact of breeding on grain yields of wheat varieties released during the 20th century has been extensively studied, whereas less information is available on the changes in gluten quality associated with effects on the amount and composition of glutenins and gliadins. In order to explore the effects of breeding during the 20th century on gluten quality of durum wheat for processing and health we have compared a set of old and modern Italian genotypes grown under Mediterranean conditions. The better technological performance observed for the modern varieties was found to be due not only to the introgression of superior alleles of high (HMW-GS) and low molecular weight (LMW-GS) glutenin subunits encoded at Glu-B1 and Glu-B3 loci, but also to differential expression of specific storage proteins. In particular, the higher gluten index observed in modern genotypes was correlated with an increased glutenin/gliadin ratio and the expression of B-type LMW-GS which was, on average, two times higher in the modern than in the old group of durum wheat genotypes. By contrast, no significant differences were found between old and modern durum wheat genotypes in relation to the expression of α-type and γ-type gliadins which are major fractions that trigger coeliac disease (CD) in susceptible individuals. Furthermore, a drastic decrease was observed in the expression of ω-type gliadins in the modern genotypes, mainly ω-5 gliadin (also known as Tri a 19) which is a major allergen in wheat dependent exercise induced anaphylaxis (WDEIA). Immunological and 2DE SDS-PAGE analyses indicated that these differences could be related either to a general down-regulation or to differences in numbers of isoforms. Lower rainfall during grain filling period was related to overall higher expression of HMW-GS and ω-gliadins. In conclusion, breeding activity carried out in Italy during the 20th century appears to have improved durum wheat gluten quality, both in relation to technological performance and allergenic potential