High frequency repetitive transcranial magnetic stimulation to the left dorsolateral prefrontal cortex modulates sensorimotor cortex function in the transition to sustained muscle pain

Based on reciprocal connections between the dorsolateral prefrontal cortex (DLPFC) and basal-ganglia regions associated with sensorimotor cortical excitability, it was hypothesized that repetitive transcranial magnetic stimulation (rTMS) of the left DLPFC would modulate sensorimotor cortical excitability induced by muscle pain. Muscle pain was provoked by injections of nerve growth factor (end of Day-0 and Day-2) into the right extensor carpi radialis brevis (ECRB) muscle in two groups of 15 healthy participants receiving 5 daily sessions (Day-0 to Day-4) of active or sham rTMS. Muscle pain scores and pressure pain thresholds (PPTs) were collected (Day-0, Day-3, Day-5). Assessment of motor cortical excitability using TMS (mapping cortical ECRB muscle representation) and somatosensory evoked potentials (SEPs) from electrical stimulation of the right radial nerve were recorded at Day-0 and Day-5. At Day-0 versus Day-5, the sham compared to active group showed: Higher muscle pain scores and reduced PPTs (P < 0.04); decreased frontal N30 SEP (P < 0.01); increased TMS map volume (P < 0.03). These results indicate that muscle pain exerts modulatory effects on the sensorimotor cortical excitability and left DLPFC rTMS has analgesic effects and modulates pain-induced sensorimotor cortical adaptations. These findings suggest an important role of prefrontal to basal-ganglia function in sensorimotor cortical excitability and pain processing

Optimal tuning and assessment of inertial dampers with grounded inerter for vibration control of seismically excited base-isolated systems

In this paper, the concept of an ideal grounded linear inerter, endowing supplemental inertia to passive linear tuned mass-dampers (TMDs) through its inertance property without increasing the TMD mass, is considered to reduce lateral displacement demands in base isolated structural systems (BISs). Optimal tuned mass-damper-inerter (TMDI) design parameters are numerically determined to maximize energy dissipation by the TMDI under stationary white noise support excitation. Performance of these optimally designed TMDI-equipped BISs is assessed for stationary white and colored noise excitations as well as for four recorded earthquake acceleration ground motions (GMs) with different non-stationary frequency content. It is found that for fixed mass ratio the inclusion of the grounded inerter reduces significantly secondary mass displacement and stroke for all considered excitations while it improves appreciably BIS displacement demands except for the particular case of a near-fault accelerogram characterized by early arrival of a high-energy low-frequency pulse as captured in its wavelet spectrogram. More importantly, it leads further to reductions to BIS acceleration demands with the exception of colored noise excitation for which an insignificant increase is noted. The positive effects of the inerter saturate with increasing inertance and BIS damping ratio demonstrating that small inertance values are more effective in vibration suppression of BISs with low inherent damping. Overall, it is recommended to combine low damping isolation layers with large inertance and low secondary mass TMDIs

Late‐ but not early‐onset blindness impairs the development of audio‐haptic multisensory integration

Integrating different senses to reduce sensory uncertainty and increase perceptual precision can have an important compensatory function for individuals with visual impairment and blindness. However, how visual impairment and blindness impact the development of optimal multisensory integration in the remaining senses is currently unknown. Here we first examined how audio‐haptic integration develops and changes across the life span in 92 sighted (blindfolded) individuals between 7 to 70 years of age. We used a child‐ friendly task in which participants had to discriminate different object sizes by touching them and/or listening to them. We assessed whether audio‐haptic performance resulted in a reduction of perceptual uncertainty compared to auditory‐only and haptic‐only performance as predicted by maximum‐likelihood estimation model. We then compared how this ability develops in 28 children and adults with different levels of visual experience, focussing on low‐vision individuals and blind individuals that lost their sight at different ages during development. Our results show that in sighted individuals, adult‐like audio‐haptic integration develops around 13‐15 years of age, and remains stable until late adulthood. While early‐blind individuals, even at the youngest ages, integrate audio‐haptic information in an optimal fashion, late‐blind individuals do not. Optimal integration in low‐vision individuals follows a similar developmental trajectory as that of sighted individuals. These findings demonstrate that visual experience is not necessary for optimal audio‐haptic integration to emerge, but that consistency of sensory information across development is key for the functional outcome of optimal multisensory integration

Pela integração da inteligência competitiva nos Enterprise Information Systems (EIS)

O objetivo deste artigo é evidenciar a importância da integração de um módulo de inteligência competitiva (coleta, organização e difusão da informação externa) nos sistemas de informações para o apoio à decisão das empresas, enriquecendo assim os Enterprise Information Systems (EIS). É a efetividade do gerente na busca da identificação ou da antecipação de problemas ou oportunidades, em um cenário de cada vez maiores pressões internas e principalmente externas. O propósito maior é fornecer amplo ambiente de oferta de informações internas e externas, formais e informais, informações sobre as percepções do mercado, informações envolvidas em análises e simulações, enfim, um ambiente integrador das informações disponíveis e relevantes para o sucesso da organização e que crie condições de proatividade para os usuários

Avaliação de cultivares de arroz irrigado da Embrapa no Rio Grande do Sul, safra 2009/10.

Anualmente, desenvolve-se um trabalho para acompanhar, avaliar e relatar o comportamento de cultivares de arroz irrigado da Embrapa, nas diferentes regiões de cultivo deste cereal no RS. Neste trabalho são relatados os resultados obtidos na safra 2009/10

Impact of Supra-Optimal Temperatures on Physiology and Yield in Rice Field.

Heat stress is an increasing constraint for the productivity of rice (Oryza sativa L.) worldwide. In this context, a study was carry out to quantify the supra-optimal temperature effects on rice yield-components and secondly to investigate its effects on plant physiological attributes when different genetic backgrounds are submitted to contrasting environment air-temperatures during the anthesis, the most sensitive growth phase to heat stress. Three Embrapa's cultivars were used, BRS Pampa, BRS Sinuelo CL and IAS 12-9 Formosa which represent indica/japonica, indica and essentially japonica subspecies, respectively. One day before anthesis phase, sub plot plants were submitted to heat stress via polythene shelters for 96 h. Photosynthesis and respiration parameters were measured at 24 and 48 h after stress, and at physiological maturity, grain carbon isotope fractionation as well as yield components and grain yield were quantified. There were significant differences among genotypes for some gas exchange parameters at ambient and under increased temperatures at 24 and 48 h after stress, such as carbon assimilation and respiration rate. Heat-stress also affected yield components, especially for BRS Sinuelo CL showing the highest spikelet sterility (54%) while BRS Pampa had the lowest value (20.80%) and the highest 1000-grain weight and grain yield. These results demonstrate that although heat tolerance has been more frequently found in indica spp, this trait can also be present in genotypes combining indica/japonica genetic background, as shown by BRS Pampa cultivar.201

ErbB in NSCLC as a molecular target: Current evidences and future directions

A number of treatments have been developed for HER1, 2 and 3-driven non-small cell lung cancer (NSCLC), of which the most successful have been the epidermal growth factor receptor-tyrosine kinase inhibitors in HER1-mutant tumours resulting in highly improved progression-free survival. Human epidermal growth factor (HER)2 and 3-driven tumours represent the minority of NSCLC, and effective therapies in these patients still represent an unmet medical need. The encouraging results seen with anti-HER2 and anti-HER3 monoclonal antibodies need to be validated in larger studies, even if the greatest obstacle is represented by the exiguous number of patients bearing deregulated HER2/3 system and abnormalities of signal transduction pathway. Considering NSCLC tumour heterogeneity, which affects response and resistance to treatment, combined multiparametric approaches, such as liquid biopsy together with radiomics, may provide a better understanding of the tumour dynamics and clonal selection during the treatments