2,589 research outputs found
Low-dimensional chaos in populations of strongly-coupled noisy maps
We characterize the macroscopic attractor of infinite populations of noisy
maps subjected to global and strong coupling by using an expansion in order
parameters. We show that for any noise amplitude there exists a large region of
strong coupling where the macroscopic dynamics exhibits low-dimensional chaos
embedded in a hierarchically-organized, folded, infinite-dimensional set. Both
this structure and the dynamics occuring on it are well-captured by our
expansion. In particular, even low-degree approximations allow to calculate
efficiently the first macroscopic Lyapunov exponents of the full system.Comment: 16 pages, 9 figures. Progress of Theoretical Physics, to appea
Noise-induced macroscopic bifurcations in globally-coupled chaotic units
Large populations of globally-coupled identical maps subjected to independent
additive noise are shown to undergo qualitative changes as the features of the
stochastic process are varied. We show that for strong coupling, the collective
dynamics can be described in terms of a few effective macroscopic degrees of
freedom, whose deterministic equations of motion are systematically derived
through an order parameter expansion.Comment: Phys. Rev. Lett., accepte
Evolving social behavior through selection of single-cell adhesion in Dictyostelium discoideum
The social amoeba Dictyostelium discoideum commonly forms chimeric fruiting bodies. Genetic variants that produce a higher proportion of spores are predicted to undercut multicellular organization unless cooperators assort positively. Cell adhesion is considered a primary factor driving such assortment, but evolution of adhesion has not been experimentally connected to changes in social performance. We modified by experimental evolution the efficiency of individual cells in attaching to a surface. Surprisingly, evolution appears to have produced social cooperators irrespective of whether stronger or weaker adhesion was selected. Quantification of reproductive success, cell-cell adhesion, and developmental patterns, however, revealed two distinct social behaviors, as captured when the classical metric for social success is generalized by considering clonal spore production. Our work shows that cell mechanical interactions can constrain the evolution of development and sociality in chimeras and that elucidation of proximate mechanisms is necessary to understand the ultimate emergence of multicellular organization
The Kuramoto model with distributed shear
We uncover a solvable generalization of the Kuramoto model in which shears
(or nonisochronicities) and natural frequencies are distributed and
statistically dependent. We show that the strength and sign of this dependence
greatly alter synchronization and yield qualitatively different phase diagrams.
The Ott-Antonsen ansatz allows us to obtain analytical results for a specific
family of joint distributions. We also derive, using linear stability analysis,
general formulae for the stability border of incoherence.Comment: 6 page
Platelet-rich gel for the adjuvant treatment of wound healing of transposed flap for arteriovenous fistula in systemic scleroderma
LETTER TO EDITO
Oscillations in Optional Public Good Games
We present a new mechanism promoting cooperative behavior among selfish individuals in the public goods game. This game represents a straightforward generalization of the prisoner's dilemma to an arbitrary number of players. In contrast to the compulsory public goods game, optional participation provides a natural way to avoid deadlocks in the state of mutual defection. The three resulting strategies - collaboration or defection in the public goods game, as well as not joining at all -are studied by means of a replicator dynamics, which can be completely analysed in spite of the fact that some payoff terms are nonlinear. If cooperation is valuable enough, the dynamics exhibits a rock-scissors-paper type of cycling between the three strategies, leading to sizeable average levels of cooperation in the population. Thus, voluntary participation makes cooperation possible. But for each strategy, the average payoff value remains equal to the earnings of those not participating in the public goods game
Design, synthesis and biological activity of selective hCAs inhibitors based on 2-(benzylsulfinyl)benzoic acid scaffold
A large library of derivatives based on the scaffold of 2-(benzylsulfinyl)benzoic acid were synthesised and tested as atypical inhibitors against four different isoforms of human carbonic anhydrase (hCA I, II, IX and XII, EC 4.2.1.1). The exploration of the chemical space around the main functional groups led to the discovery of selective hCA IX inhibitors in the micromolar/nanomolar range, thus establishing robust structure-activity relationships within this versatile scaffold. HPLC separation of some selected chiral compounds and biological evaluation of the corresponding enantiomers was performed along with molecular modelling studies on the most active derivatives
Synchronization and oscillator death in oscillatory media with stirring
The effect of stirring in an inhomogeneous oscillatory medium is
investigated. We show that the stirring rate can control the macroscopic
behavior of the system producing collective oscillations (synchronization) or
complete quenching of the oscillations (oscillator death). We interpret the
homogenization rate due to mixing as a measure of global coupling and compare
the phase diagrams of stirred oscillatory media and of populations of globally
coupled oscillators.Comment: to appear in Phys. Rev. Let
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