H.264 sensor aided video encoder for UAV BLOS missions

This paper presents a new low-complexity H.264 encoder, based on x264 implementation, for Unmanned Aerial Vehicles (UAV) applications. The encoder employs a new motion estimation scheme which make use of the global motion information provided by the onboard navigation system. The results are relevant in low frame rate video coding, which is a typical scenario in UAV behind line-of-sight (BLOS) missions

Nutraceuticals for peripheral vestibular pathology: Properties, usefulness, future perspectives and medico-legal aspects

Vestibular disorders may generate complex signs and symptoms, which may alter pa-tients’ balance and the quality of life. Dizziness and vertigo can strongly affect daily activities and relations. Despite the presence of conventional drugs, maneuvers, and surgery, another interesting therapeutic opportunity is offered by nutraceuticals. These molecules are often used in the treatment of dizziness and vertigo, but the rationale of their application is not always solidly demon-strated by the scientific evidence. Several substances have shown a variable level of efficacy/useful-ness in this field, but there is lack of important evidence for most of them. From a medico-legal point of view, specific information must be provided to the patient regarding the efficacy and possibilities that the use of these preparations can allow. Administering the right nutraceutical to the proper patient is a fundamental clinical skill. Integrating conventional drug treatment with nutraceutical administration seems to be easy, but it may be difficult considering the (in part unexplored) phar-macodynamics and pharmacokinetics of nutraceuticals. The aim of the scientific community should be to elevate nutraceuticals to the same law and technical dignity of conventional drugs

Drug–drug interactions in vestibular diseases, clinical problems, and medico-legal implications

Peripheral vestibular disease can be treated with several approaches (e.g., maneuvers, surgery, or medical approach). Comorbidity is common in elderly patients, so polytherapy is used, but it can generate the development of drug–drug interactions (DDIs) that play a role in both adverse drug reactions and reduced adherence. For this reason, they need a complex kind of approach, considering all their individual characteristics. Physicians must be able to prescribe and deprescribe drugs based on a solid knowledge of pharmacokinetics, pharmacodynamics, and clinical indications. Moreover, full information is required to reach a real therapeutic alliance, to improve the safety of care and reduce possible malpractice claims related to drug–drug interactions. In this review, using PubMed, Embase, and Cochrane library, we searched articles published until 30 August 2021, and described both pharmacokinetic and pharmacodynamic DDIs in patients with vestibular disorders, focusing the interest on their clinical implications and on risk management strategies

The Cu-Zn superoxide dismutase (SOD1) inhibits ERK phosphorylation by muscarinic receptor modulation in rat pituitary GH3 cells

The Cu-Zn superoxide dismutase (SOD1) belongs to a family of isoenzymes that are able to dismutate the oxygen superoxide in hydrogen peroxide and molecular oxygen. This enzyme is secreted by many cellular lines and it is also released trough a calcium-dependent depolarization mechanism involving SNARE protein SNAP 25. Using rat pituitary GH3 cells that express muscarinic receptors we found that SOD1 inhibits P-ERK1/2 pathway trough an interaction with muscarinic M1 receptor. This effect is strengthened by oxotremorine, a muscarinic M agonist and partially reverted by pyrenzepine, an antagonist of M1 receptor; moreover this effect is independent from increased intracellular calcium concentration induced by SOD1. Finally, P-ERK1/2 inhibition was accompanied by the reduction of GH3 cell proliferation. These data indicate that SOD1 beside the well studied antioxidant properties can be considered as a neuromodulator able to affect mitogen-activated protein kinase in rat pituitary cells trough a M1 muscarinic receptor

Sensor aided H.264 video encoder for UAV applications

This paper presents a new low-complexity H.264 encoder for Unmanned Aerial Vehicles (UAV) applications. Standard video coding systems currently employed in UAV applications do not rely on some peculiarities in terms of scene 3D model and correlation among successive frames. In particular, the observed scene is static, i.e. the camera movement is dominant, and it can often be well approximated with a plane. Moreover, camera position and orientation can be obtained from the navigation system. Therefore, correspondent points on two video frames are linked by a simple homography. The encoder employs a new motion estimation scheme which make use of the global motion information provided by the onboard navigation system. The homography is used in order to initialize the block matching algorithm allowing a more robust motion estimation and a smaller search window, and hence reducing the complexity. Experimental results show that the proposed scheme ouperforms standard H.264 in terms of PSNR and throughput. The results are relevant in low frame rate video coding, which is a typical scenario in UAV behind line-of-sight (BLOS) missions. Experiments open new drections in developing new sensor aided video coding standard

Haemorrhage from varicose veins and varicose ulceration: A systematic review

Varicose veins (VVs) and varicose ulceration (VU) are usually considered non-life-threatening conditions, but in some cases they can lead to major complications such as fatal bleeding. The aim of this systematic review is to evidence the most updated information on bleeding from VV and VU. As evidence acquisition, we planned to include all the studies dealing with “Haemorrhage/Bleeding” and “VVs/VU”. We excluded all the studies, which did not properly fit our research question, and with insufficient data. As evidence synthesis, of the 172 records found, after removing of duplicates, and after records excluded in title and abstract, 85 matched our inclusion criteria. After reading the full-text articles, we decided to exclude 68 articles because of the following reasons: (1) not responding properly to our research questions; (2) insufficient data; the final set included 17 articles. From literature searching, we identify the following main issues to be discussed in the review: epidemiology and predisposing factors, pathophysiology and forensic aspects, first aid. It has been estimated that deaths for bleeding due to peripheral venous problems account up to 0.01% of autopsy cases. From a pathological point of view, venous bleeding may arise from either acute or chronic perforation of an enlarged vein segment through the weakened skin. From a forensic point of view, in cases of fatal haemorrhage the death scene can even simulate non-natural events, due to crime or suicide. In most cases, incorrect first aid led to fatal complications. Further investigation on epidemiology and prevention measures are needed

Mechanisms underlying Reactive Oxygen Species (ROS) induction by platelet derived growth factor receptor pathway

Abstract a Congress

Management of the corpse with suspect, probable or confirmed COVID-19 respiratory infection – Italian interim recommendations for personnel potentially exposed to material from corpses, including body fluids, in morgue structures and during autopsy practice

37nononenoneFineschi V.; Aprile A.; Aquila I.; Arcangeli M.; Asmundo A.; Bacci M.; Cingolani M.; Cipolloni L.; D'Errico S.; de Casamassimi I.; Mizio G.D.; Paolo M.D.; Focardi M.; Frati P.; Gabbrielli M.; Russa R.L.; Maiese A.; Manetti F.; Martelloni M.; Mazzeo E.; Montana A.; Neri M.; Padovano M.; Pinchi V.; Pomara C.; Ricci P.; Salerno M.; Santurro A.; Scopetti M.; Testi R.; Turillazzi E.; Vacchiano G.; Crivelli F.; Bonoldi E.; Facchetti F.; Nebuloni M.; Sapino A.Fineschi, V.; Aprile, A.; Aquila, I.; Arcangeli, M.; Asmundo, A.; Bacci, M.; Cingolani, M.; Cipolloni, L.; D'Errico, S.; de Casamassimi, I.; Mizio, G. D.; Paolo, M. D.; Focardi, M.; Frati, P.; Gabbrielli, M.; Russa, R. L.; Maiese, A.; Manetti, F.; Martelloni, M.; Mazzeo, E.; Montana, A.; Neri, M.; Padovano, M.; Pinchi, V.; Pomara, C.; Ricci, P.; Salerno, M.; Santurro, A.; Scopetti, M.; Testi, R.; Turillazzi, E.; Vacchiano, G.; Crivelli, F.; Bonoldi, E.; Facchetti, F.; Nebuloni, M.; Sapino, A