A New Theory of Consciousness: The Missing Link - Organization

What is consciousness and what is the missing link between the sensory input and the cortical centre in the brain for consciousness? In the literature there are more than a million pages written about consciousness. The perspectives range from the field of metaphysics to those of quantum mechanics. However, no one today has produced a theory which is universally accepted. Consciousness is “something” which the majority of humans know that they posses, they use it when they want to understand their environment. However, no individual human knows whether other humans also posses consciousness. unless some tests such as she is looking at me, he is talking etc., are performed. We are caught in an intellectual sort of recursive carousel – we need consciousness to understand consciousness. To understand consciousness we have to understand the mechanism of its function, which is to effectively organize sensory inputs from our environment. Consciousness is the outcome of the process of organizing these sensory inputs. This implies that organization is an act which precedes consciousness. Since every activity in nature is to organize/disorganize, what is the element which compels this action? I am proposing that just like energy is the physical element that causes action, there is another physical element I have called it NASCIUM which has the capacity to cause organization. This is the missing link. Understanding the nature of organization, i.e. nascium, will enhance our capability to understand consciousness

Conformations Of A Model Protein Revealed By An Aggregating Cuᴵᴵ Porphyrin: Sensing The Difference

Aggregated t-CuP binds to poly-L-glutamate through supramolecular interactions, revealing itself to be an extremely sensitive probe for the major conformations of the polymeric scaffold

Redox control of multidrug resistance and Its possible modulation by antioxidants

Clinical efficacy of anticancer chemotherapies is dramatically hampered by multidrug resistance (MDR) dependent on inherited traits, acquired defence against toxins, and adaptive mechanisms mounting in tumours. There is overwhelming evidence that molecular events leading to MDR are regulated by redox mechanisms. For example, chemotherapeutics which overrun the first obstacle of redox-regulated cellular uptake channels (MDR1, MDR2, and MDR3) induce a concerted action of phase I/II metabolic enzymes with a temporal redox-regulated axis. This results in rapid metabolic transformation and elimination of a toxin. This metabolic axis is tightly interconnected with the inducible Nrf2-linked pathway, a key switch-on mechanism for upregulation of endogenous antioxidant enzymes and detoxifying systems. As a result, chemotherapeutics and cytotoxic by-products of their metabolism (ROS, hydroperoxides, and aldehydes) are inactivated and MDR occurs. On the other hand, tumour cells are capable of mounting an adaptive antioxidant response against ROS produced by chemotherapeutics and host immune cells. The multiple redox-dependent mechanisms involved in MDR prompted suggesting redox-active drugs (antioxidants and prooxidants) or inhibitors of inducible antioxidant defence as a novel approach to diminish MDR. Pitfalls and progress in this direction are discussed

Invariance: a Theoretical Approach for Coding Sets of Words Modulo Literal (Anti)Morphisms

Let $A$ be a finite or countable alphabet and let $\theta$ be literal (anti)morphism onto $A^*$ (by definition, such a correspondence is determinated by a permutation of the alphabet). This paper deals with sets which are invariant under $\theta$ ($\theta$-invariant for short).We establish an extension of the famous defect theorem. Moreover, we prove that for the so-called thin $\theta$-invariant codes, maximality and completeness are two equivalent notions. We prove that a similar property holds in the framework of some special families of $\theta$-invariant codes such as prefix (bifix) codes, codes with a finite deciphering delay, uniformly synchronized codes and circular codes. For a special class of involutive antimorphisms, we prove that any regular $\theta$-invariant code may be embedded into a complete one.Comment: To appear in Acts of WORDS 201

Supergiant Fast X-ray Transients uncovered by the EXTraS project: flares reveal the development of magnetospheric instability in accreting neutron stars

The low luminosity, X-ray flaring activity, of the sub-class of high mass X-ray binaries called Supergiant Fast X-ray Transients, has been investigated using XMM-Newton public observations, taking advantage of the products made publicly available by the EXTraS project. One of the goals of EXTraS was to extract from the XMM-Newton public archive information on the aperiodic variability of all sources observed in the soft X-ray range with EPIC (0.2-12 keV). Adopting a Bayesian block decomposition of the X-ray light curves of a sample of SFXTs, we picked out 144 X-ray flares, covering a large range of soft X-ray luminosities (1e32-1e36 erg/s). We measured temporal quantities, like the rise time to and the decay time from the peak of the flares, their duration and the time interval between adjacent flares. We also estimated the peak luminosity, average accretion rate and energy release in the flares. The observed soft X-ray properties of low-luminosity flaring activity from SFXTs is in qualitative agreement with what is expected by the application of the Rayleigh-Taylor instability model in accreting plasma near the neutron star magnetosphere. In the case of rapidly rotating neutron stars, sporadic accretion from temporary discs cannot be excluded.Comment: Accepted for publication in MNRAS (accepted 2019 May 1; received 2019 April 30; in original form 2019 February 25). 22 pages, 16 figures, 3 tables

Target motion estimation via a multistatic FSR

The focus of this paper is on the estimation of the kinematic parameters of moving targets via a MIMO Forward Scatter Radar (FSR) system. A sub-optimum estimation technique is considered that exploits the information concerning the time instants at which the target crosses the individual baselines to retrieve the motion parameters. The accuracy of such technique is firstly investigated from a theoretical point of view and then the effectiveness of the proposed approach is demonstrated by applying it to live MIMO FSR data. Shown results prove the practical applicability of the proposed technique

Discovery of periodic dips in the brightest hard X-ray source of M31 with EXTraS

We performed a search for eclipsing and dipping sources in the archive of the EXTraS project - a systematic characterization of the temporal behaviour of XMM-Newton point sources. We discovered dips in the X-ray light curve of 3XMM J004232.1+411314, which has been recently associated with the hard X-ray source dominating the emission of M31. A systematic analysis of XMM-Newton observations revealed 13 dips in 40 observations (total exposure time $\sim$0.8 Ms). Among them, four observations show two dips, separated by $\sim$4.01 hr. Dip depths and durations are variable. The dips occur only during low-luminosity states (L$_{0.2-12}<1\times10^{38}$ erg s$^{-1}$), while the source reaches L$_{0.2-12}\sim2.8\times10^{38}$ erg s$^{-1}$. We propose this system to be a new dipping Low-Mass X-ray Binary in M31 seen at high inclination (60$^{\circ}$-80$^{\circ}$), the observed dipping periodicity is the orbital period of the system. A blue HST source within the Chandra error circle is the most likely optical counterpart of the accretion disk. The high luminosity of the system makes it the most luminous dipper known to date.Comment: 11 pages, 2 figures, 5 tables, accepted for publication in ApJ

POD and SPOD analysis of vertical liquid sheet

Modal analysis of thin liquid sheet driven by a harmonic forcing in the lateral velocity component at the inlet section is performed. Proper orthogonal decomposition (POD) and spectral POD (SPOD) techniques have been applied on two-dimensional two-phase numerical simulations data, obtained with the VOF approach, to characterize the main spatial and temporal structures. The investigation is carried out varying the Weber number and the Reynolds number. In supercritical regime (Weber number, > 1) both POD and SPOD techniques yield only leading sinuous modes, featuring a traveling perturbation. Spectral analysis confirms the occurrence of a discontinuity in frequency response between the supercritical and subcritical regimes. In subcritical regime ( < 1) the excitation of a combined sinuous-varicose motion is detected when the system is driven at resonance frequency for relatively high Reynolds numbers