Fuzzy clustering of spatial interval-valued data

In this paper, two fuzzy clustering methods for spatial intervalvalued data are proposed, i.e. the fuzzy C-Medoids clustering of spatial interval-valued data with and without entropy regularization. Both methods are based on the Partitioning Around Medoids (PAM) algorithm, inheriting the great advantage of obtaining non-fictitious representative units for each cluster. In both methods, the units are endowed with a relation of contiguity, represented by a symmetric binary matrix. This can be intended both as contiguity in a physical space and as a more abstract notion of contiguity. The performances of the methods are proved by simulation, testing the methods with different contiguity matrices associated to natural clusters of units. In order to show the effectiveness of the methods in empirical studies, three applications are presented: the clustering of municipalities based on interval-valued pollutants levels, the clustering of European fact-checkers based on interval-valued data on the average number of impressions received by their tweets and the clustering of the residential zones of the city of Rome based on the interval of price values

Article 6 Piloting: State of Play and Stakeholder Experiences

This report is the 3rd edition of a series started in 2019 and provides an updated overview of all aspects related to the piloting and operationalization of Article 6 of the Paris Agreement. Despite the continued uncertainty regarding the finalization of the Article 6 rules, practical Article 6 piloting is continuing apace and the landscape of Article 6 piloting initiatives evolves. Testing how Article 6 cooperation could work in practice in order to inform negotiations as well as getting early access to sources of emissions credits is seen as important to fulfill national mitigation commitments. As a framework for the analysis in our study, we apply a ‘concentric ring’ model that clearly differentiates between piloting activities that aim at generating Internationally Transferred Mitigation Outcomes (ITMOs) or adaptation benefits (ABs), initiatives that will eventually be governed by Article 6 rules and the enabling environment, which is essential to drive piloting efforts forward. In an additional analytical step, we classify piloting activities in the inner circle according to three different phases: the preparatory phase, the pilot phase and the full implementation phase. Moreover, we summarise current stakeholder experiences with Article 6 piloting and provide an overview of our insights from broad and deep stakeholder consultations, including the views of buyer countries, host countries and project developers

Cannabinoid receptor 2 signaling in neurodegenerative disorders: From pathogenesis to a promising therapeutic target

As a consequence of an increasingly aging population, the number of people affected by neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease and Huntington's disease, is rapidly increasing. Although the etiology of these diseases has not been completely defined, common molecular mechanisms including neuroinflammation, excitotoxicity and mitochondrial dysfunction have been confirmed and can be targeted therapeutically. Moreover, recent studies have shown that endogenous cannabinoid signaling plays a number of modulatory roles throughout the central nervous system (CNS), including the neuroinflammation and neurogenesis. In particular, the up-regulation of type-2 cannabinoid (CB2) receptors has been found in a number of neurodegenerative disorders. Thus, the modulation of CB2 receptor signaling may represent a promising therapeutic target with minimal psychotropic effects that can be used to modulate endocannabinoid-based therapeutic approaches and to reduce neuronal degeneration. For these reasons this review will focus on the CB2 receptor as a promising pharmacological target in a number of neurodegenerative diseases

Carbon nanotube film/silicon heterojunction photodetector for new cutting-edge technological devices

Photodetector (PD) devices based on carbon nanotube/n-silicon heterojunction (NSH) have been realized, with a linear response in a large optical power range, proving competitive performances with respect to a recent nanostructure-based detector and those currently available on the market. The core of these devices is a thin semi-transparent and conductive single-walled carbon nanotubes film with a multitask role: junction element, light absorber and transmitter, photocarrier transporting layer, and charge collector. The PD exhibits rise times of some nanoseconds, detecting light from ultraviolet (240 nm) to infrared (1600 nm), and external quantum efficiency reaching 300% in the VIS spectra region

Le Elezioni Politiche 2013

Le elezioni politiche del 24 e 25 febbraio 2013 hanno sancito un forte cambiamento della struttura del sistema partitico italiano. In un contesto di altissima volatilità elettorale e di accelerato declino della partecipazione al voto, il sistema è divenuto sostanzialmente tripolare, dopo vent’anni di strutturazione e tenuta del bipolarismo. A questo esito hanno concorso da un lato l’erosione dei principali schieramenti politici che a partire dal novembre 2011 avevano sostenuto l’esperienza del governo Monti (nonché la deludente prova elettorale dello stesso Presidente del Consiglio uscente), e dall’altro lo straordinario successo del Movimento 5 stelle. Quest’ultimo, al primo test elettorale di livello nazionale, ha raccolto un risultato sorprendente, giungendo ad oltre un quarto dei voti validi. Siamo di fronte ad una parentesi momentanea dovuta all’effetto combinato di crisi economica e crisi politica, oppure le contraddizioni interne alla Seconda Repubblica l’hanno condotta effettivamente al suo crepuscolo? Come uscirà il sistema partitico italiano da questa nuova fase di destabilizzazione? Questo quarto Dossier CISE, che raccoglie contributi apparsi sul sito web del Cise prima e dopo le elezioni, fornisce una prima analisi del voto, presentando elaborazioni su dati aggregati, stime dei flussi elettorali, alcune prime analisi su dati di sondaggio, nonché una panoramica dei nuovi eletti e un’appendice ricca di tabelle e mappe riassuntive del risultato elettorale. Come i precedenti Dossier, si tratta di uno strumento prodotto rapidamente all’indomani del voto, con l’intento di suggerire primi spunti di interpretazione da approfondire in seguito, cercando di contribuire alla lettura di un risultato elettorale cruciale, in una delicata fase di cambiamento del sistema partitico italiano

Measurement of Glutathionylated Haemoglobin by MALDI-ToF Mass Spectrometry as a Biomarker of Oxidative Stress in Heavy Smokers and in Occupational Obese Subjects

Glutathionyl-haemoglobin (Hb-SSG) is a minor form of haemoglobin characterized by the presence of a disulfide bond between the β-93 cysteine residue and the thiol group of glutathione. Hb-SSG is naturally present in the erythrocytes at levels comparable to those of glycated haemoglobin and can be measured by MALDI mass spectrometry on very small samples of erythrocytes from peripheral blood. Since Hb-SSG has been recognized as a sensitive biomarker of oxidative stress in several degenerative diseases (diabetes, hyperlipidemia, kidney disease) and in healthy workers exposed to glutathione-depleting toxic agents such as butadiene, we have measured for the first time the levels of Hb-SSG in two groups: healthy heavy cigarette smokers and overweight-obese

Equilibrium and off-equilibrium simulations of the 4d Gaussian spin glass

In this paper we study the on and off-equilibrium properties of the four dimensional Gaussian spin glass. In the static case we determine with more precision that in previous simulations both the critical temperature as well as the critical exponents. In the off-equilibrium case we settle the general form of the autocorrelation function, and show that is possible to obtain dynamically, for the first time, a value for the order parameter.Comment: 16 pages and 13 figures, uses epsfig.sty and rotate.sty. Some minor grammatical changes. Also available at http://chimera.roma1.infn.it/index_papers_complex.htm