Transition from decelerated to accelerated cosmic expansion in braneworld universes

Braneworld theory provides a natural setting to treat, at a classical level, the cosmological effects of vacuum energy. Non-static extra dimensions can generally lead to a variable vacuum energy, which in turn may explain the present accelerated cosmic expansion. We concentrate our attention in models where the vacuum energy decreases as an inverse power law of the scale factor. These models agree with the observed accelerating universe, while fitting simultaneously the observational data for the density and deceleration parameter. The redshift at which the vacuum energy can start to dominate depends on the mass density of ordinary matter. For Omega = 0.3, the transition from decelerated to accelerated cosmic expansion occurs at z approx 0.48 +/- 0.20, which is compatible with SNe data. We set a lower bound on the deceleration parameter today, namely q > - 1 + 3 Omega/2, i.e., q > - 0.55 for Omega = 0.3. The future evolution of the universe crucially depends on the time when vacuum starts to dominate over ordinary matter. If it dominates only recently, at an epoch z < 0.64, then the universe is accelerating today and will continue that way forever. If vacuum dominates earlier, at z > 0.64, then the deceleration comes back and the universe recollapses at some point in the distant future. In the first case, quintessence and Cardassian expansion can be formally interpreted as the low energy limit of our model, although they are entirely different in philosophy. In the second case there is no correspondence between these models and ours.Comment: In V2 typos are corrected and one reference is added for section 1. To appear in General Relativity and Gravitatio

Accelerated expansion from braneworld models with variable vacuum energy

In braneworld models a variable vacuum energy may appear if the size of the extra dimension changes during the evolution of the universe. In this scenario the acceleration of the universe is related not only to the variation of the cosmological term, but also to the time evolution of $G$ and, possibly, to the variation of other fundamental "constants" as well. This is because the expansion rate of the extra dimension appears in different contexts, notably in expressions concerning the variation of rest mass and electric charge. We concentrate our attention on spatially-flat, homogeneous and isotropic, brane-universes where the matter density decreases as an inverse power of the scale factor, similar (but at different rate) to the power law in FRW-universes of general relativity. We show that these braneworld cosmologies are consistent with the observed accelerating universe and other observational requirements. In particular, $G$ becomes constant and $\Lambda_{(4)} \approx const \times H^2$ asymptotically in time. Another important feature is that the models contain no "adjustable" parameters. All the quantities, even the five-dimensional ones, can be evaluated by means of measurements in 4D. We provide precise constrains on the cosmological parameters and demonstrate that the "effective" equation of state of the universe can, in principle, be determined by measurements of the deceleration parameter alone. We give an explicit expression relating the density parameters $\Omega_{\rho}$, $\Omega_{\Lambda}$ and the deceleration parameter $q$. These results constitute concrete predictions that may help in observations for an experimental/observational test of the model.Comment: References added, typos correcte

Identification of a common HLA-DP4-restricted T-cell epitope in the conserved region of the respiratory syncytial virus G protein

The cellular immune response to respiratory syncytial virus (RSV) is important in both protection and immunopathogenesis. In contrast to HLA class I, HLA class II-restricted RSV-specific T-cell epitopes have not been identified. Here, we describe the generation and characterization of two human RSV-specific CD4(+)-T-cell clones (TCCs) associated with type 0-like cytokine profiles. TCC 1 was specific for the matrix protein and restricted over HLA-DPB1*1601, while TCC 2 was specific for the attachment protein G and restricted over either HLA-DPB1*0401 or -0402. Interestingly, the latter epitope is conserved in both RSV type A and B viruses. Given the high allele frequencies of HLA-DPB1*0401 and -0402 worldwide, this epitope could be widely recognized and boosted by recurrent RSV infections. Indeed, peptide stimulation of peripheral blood mononuclear cells from healthy adults resulted in the detection of specific responses in 8 of 13 donors. Additional G-specific TCCs were generated from three of these cultures, which recognized the identical (n = 2) or almost identical (n = 1) HLA-DP4-restricted epitope as TCC 2. No significant differences were found between the capacities of cell lines obtained from infants with severe (n = 41) or mild (n = 46) RSV lower respiratory tract infections to function as antigen-presenting cells to the G-specific TCCs, suggesting that the severity of RSV disease is not linked to the allelic frequency of HLA-DP4. In conclusion, we have identified an RSV G-specific human T helper cell epitope restricted by the widely expressed HLA class II alleles DPB1*0401 and -0402. Its putative role in protection and/or immunopathogenesis remains to be determined

Some peculiarities of motion of neutral and charged test particles in the field of a spherically symmetric charged object in General Relativity

We propose the method of investigation of radial motions for charged and neutral test particles in the Reissner-Nordstr\"{o}m field by means of mass potential. In this context we analyze special features of interaction of charges and their motions in General Relativity and construct the radial motion classification. For test particles and a central source with charges $q$ and $Q$, respectively, the conditions of attraction (when $qQ>0$) and repulsion (when $qQ<0$) are obtained. The conditions of motionless test particle states with respect to the central source are investigated and, in addition, stability conditions for such static equilibrium states are found. It is shown that stable states are possible only for the bound states of weakly charged particles in the field of a naked singularity. Frequencies of small oscillations of test particles near their equilibrium positions are also found.Comment: 15 pages, 9 figure

FRW Cosmology From Five Dimensional Vacuum Brans-Dicke Theory

We follow approach of induced matter theory for 5D vacuum BD, introduce induced matter and potential in 4D hypersurfaces, and employ generalized FRW type solution. We confine ourselves to scalar field and scale factors be functions of the time. This makes the induced potential, by its definition, vanishes. When the scale factor of fifth dimension and scalar field are not constants, 5D eqs for any geometry admit a power law relation between scalar field and scale factor of fifth dimension. Hence the procedure exhibits that 5D vacuum FRW like eqs are equivalent, in general, to corresponding 4D vacuum ones with the same spatial scale factor but new scalar field and coupling constant. We show that 5D vacuum FRW like eqs or its equivalent 4D vacuum ones admit accelerated solutions. For constant scalar field, eqs reduce to usual FRW eqs with typical radiation dominated universe. For this situation we obtain dynamics of scale factors for any geometry without any priori assumption. For nonconstant scalar fields and spatially flat geometries, solutions are found to be power law and exponential ones. We also employ weak energy condition for induced matter, that allows negative/positive pressures. All types of solutions fulfill WEC in different ranges. The power law solutions with negative/positive pressures admit both decelerating and accelerating ones. Some solutions accept shrinking extra dimension. By considering nonghost scalar fields and recent observational measurements, solutions are more restricted. We illustrate that accelerating power law solutions, which satisfy WEC and have nonghost fields, are compatible with recent observations in ranges -4/3 < \omega </- -1.3151 and 1.5208 </- n < 1.9583 for dependence of fifth dimension scale factor with usual scale factor. These ranges also fulfill condition nonghost fields in the equivalent 4D vacuum BD eqs.Comment: 18 pages, 16 figures, 11 table

Isotope Effect for the Penetration Depth in Superconductors

We show that various factors can lead to an isotopic dependence of the penetration depth $\delta$. Non-adiabaticity (Jahn-Teller crossing) leads to the isotope effect of the charge carrier concentration $n$ and, consequently, of $\delta$ in doped superconductors such as the cuprates. A general equation relating the isotope coefficients of $T_c$ and of $\delta$ is presented for London superconductors. We further show that the presence of magnetic impurities or a proximity contact also lead to an isotopic dependence of $\delta$; the isotope coefficient turns out to be temperature dependent, $\beta(T)$, in these cases. The existence of the isotope effect for the penetration depth is predicted for conventional as well as for high-temperature superconductors. Various experiments are proposed and/or discussed.Comment: 11 pages, 8 figures, accepted for publication in Phys. Rev.

Seminal magnetic fields from Inflato-electromagnetic Inflation

We extend some previous attempts to explain the origin and evolution of primordial magnetic fields during inflation induced from a 5D vacuum. We show that the usual quantum fluctuations of a generalized 5D electromagnetic field cannot provide us with the desired magnetic seeds. We show that special fields without propagation on the extra non-compact dimension are needed to arrive to appreciable magnetic strengths. We also identify a new magnetic tensor field $B_{ij}$ in this kind of extra dimensional theories. Our results are in very good agreement with observational requirements, in particular from TeV Blazars and CMB radiation limits we obtain that primordial cosmological magnetic fields should be close scale invariance.Comment: Improved version. arXiv admin note: text overlap with arXiv:1007.3891 by other author

Cranberry A-type proanthocyanidins selectively target acute myeloid leukemia cells

Most elderly patients affected with acute myeloid leukemia (AML) will relapse and die of their disease even after achieving complete remission, thus emphasizing the urgent need for new therapeutic approaches with minimum toxicity to normal hematopoietic cells. Cranberry (Vaccinium spp.) extracts have exhibited anticancer and chemopreventive properties that have been mostly attributed to A-type proanthocyanidin (A-PAC) compounds. A-PACs, isolated from a commercially available cranberry extract, were evaluated for their effects on leukemia cell lines, primary AML samples, and normal CD34+ cord blood specimens. Our results indicated potent and specific antileukemia activity in vitro. In addition, the antileukemia activity of A-PACs extended to malignant progenitor and stem cell populations, sparing their normal counterparts. The antileukemia effects of A-PACs were also observed in vivo using patient derived xenografts. Surprisingly, we found that the mechanism of cell death was driven by activation of NF-κB. Overall, our data suggest that A-PACs could be used to improve treatments for AML by targeting leukemia stem cells through a potentially novel pathway

Nodal precession of WASP-33b for 11 yr by Doppler tomographic and transit photometric observations

Stars and planetary system

Involvement of MBD4 inactivation in mismatch repair-deficient tumorigenesis

The DNA glycosylase gene MBD4 safeguards genomic stability at CpG sites and is frequently mutated at coding poly-A tracks in mismatch repair (MMR)-defective colorectal tumors (CRC). Mbd4 biallelic inactivation in mice provided conflicting results as to its role in tumorigenesis. Thus, it is unclear whether MBD4 alterations are only secondary to MMR defects without functional consequences or can contribute to the mutator phenotype. We investigated MBD4 variants in a large series of hereditary/familial and sporadic CRC cases. Whereas MBD4 frameshifts were only detected in tumors, missense variants were found in both normal and tumor DNA. In CRC with double-MBD4/MMR and single-MBD4 variants, transition mutation frequency was increased, indicating that MBD4 defects may affect the mutational landscape independently of MMR defect. Mbd4-deficient mice showed reduced survival when combined with Mlh1−/− genotype. Taken together, these data suggest that MBD4 inactivation may contribute to tumorigenesis, acting as a modifier of MMR-deficient cancer phenotype