Tussenbalans

Niet UB, maar tijdelijk ter bevordering van de PDF bestanden in het Leids Repositorium

Tussenbalans

Niet UB, maar tijdelijk ter bevordering van de PDF bestanden in het Leids Repositorium

Forced swim stressor: trends in usage and mechanistic consideration

The acquired immobility response during the "forced swim test (FST)" is not a rodent model of depression, but the test has some validity in predicting a compound's antidepressant potential. Nevertheless, 60% of the about 600 papers that were published annually the past 2 years label the rodent's immobility response as depression-like behaviour, but the relative contribution per country is changing. When the Editors-in-Chief of 5 journals publishing most FST papers were asked for their point of view on labelling immobility as depression-like behaviour and despair, they responded that they primarily rely on the reviewers regarding scientific merit of the submission. One Editor informs authors of the recent NIMH notice () which encourages investigators to use animal models "for" addressing neurobiological questions rather than as model "of" specific mental disorders. The neurobiological questions raised by use of the FST fall in two categories. First, research on the role of endocrine and metabolic factors, with roots in the 1980s, and with focus on the bottom-up action of glucocorticoids on circuits processing salient information, executive control and memory consolidation. Second, recent findings using novel technological and computational advances that have allowed great progress in charting top-down control in the switch from active to passive coping with the inescapable stressor executed by neuronal ensembles of the medial prefrontal cortex via the peri-aquaductal grey. It is expected that combining neural top-down and endocrine bottom-up approaches will provide new insights in the role of stress-coping and adaptation in pathogenesis of mental disorders.Diabetes mellitus: pathophysiological changes and therap

COVID-19 risk, course and outcome in people with mental disorders: a systematic review and meta-analyses

Stress and Psychopatholog

Stress and estrous cycle affect strategy but not performance of female C57BL/6J mice

Stress induces a switch in learning strategies of male C57BL/6J mice from predominantly spatial to more stimulus-response learning. To study generalization of these findings over sex, we investigated female C57BL/6J mice at three phases of the estrous cycle under non stress and acute (10 min) restraint stress conditions. On a circular hole board (CHB) task, about half of the naive female mice used spatial and stimulus-response strategies to solve the task. Under stress, female mice favored spatial over stimulus-response strategies, with 100% of female mice in the estrus phase. Performance expressed as latency to solve the task is only improved in stressed female mice in the estrus phase. We conclude that the use of learning strategies is influenced by sex and this difference between sexes is aggravated by acute stress

Lifetime achievement from a brain-adrenal perspective: On the CRF-urocortin-glucocorticoid balance

Diabetes mellitus: pathophysiological changes and therap

From Receptor Balance to Rational Glucocorticoid Therapy

Diabetes mellitus: pathophysiological changes and therap