ECONOMICS OF BIOMASS GASIFICATION/COMBUSTION AT FUEL ETHANOL PLANTS

Published in Applied Engineering in Agriculture, Vol. 25(3): 391‐400Ethanol, Biomass, Economics, CHP, Emissions, Process heat, Electricity production, Resource /Energy Economics and Policy,

INTEGRATING BIOMASS TO PRODUCE HEAT AND POWER AT ETHANOL PLANTS

Published in: Applied Engineering in Agriculture, Vol. 25(2): 227‐244Biomass, Renewable, Sustainable, Model, Gasification, Combustion, Emissions, Ethanol production, Combined heat and power, Resource /Energy Economics and Policy,

Smooth HI Low Column Density Outskirts In Nearby Galaxies

This is an author-created, un-copyedited version of an article published in The Astronomical Journal. The Version of Record is available online at https://doi.org/10.3847/1538-3881/aabbaa.The low column density gas at the outskirts of galaxies as traced by the 21 cm hydrogen line emission (H i) represents the interface between galaxies and the intergalactic medium, i.e., where galaxies are believed to get their supply of gas to fuel future episodes of star formation. Photoionization models predict a break in the radial profiles of H i at a column density of ∼5 × 10 19 cm -2 due to the lack of self-shielding against extragalactic ionizing photons. To investigate the prevalence of such breaks in galactic disks and to characterize what determines the potential edge of the H i disks, we study the azimuthally averaged H i column density profiles of 17 nearby galaxies from the H i Nearby Galaxy Survey and supplemented in two cases with published Hydrogen Accretion in LOcal GAlaxieS data. To detect potential faint H i emission that would otherwise be undetected using conventional moment map analysis, we line up individual profiles to the same reference velocity and average them azimuthally to derive stacked radial profiles. To do so, we use model velocity fields created from a simple extrapolation of the rotation curves to align the profiles in velocity at radii beyond the extent probed with the sensitivity of traditional integrated H i maps. With this method, we improve our sensitivity to outer-disk H i emission by up to an order of magnitude. Except for a few disturbed galaxies, none show evidence of a sudden change in the slope of the H i radial profiles: the alleged signature of ionization by the extragalactic background.Peer reviewedFinal Accepted Versio

Feminist Experiences of ‘Studying up’: Encounters with International Institutions

Feminist Experiences of \u27Studying up\u27: Encounters with International Institutions This article makes the case for feminist IR to build knowledge of international institutions. It emerges from a roundtable titled ‘Challenges and Opportunities for Feminist IR: Researching Gendered Institutions’ which took place at the International Studies Association Annual Convention in Baltimore in 2017. Here, we engage in self-reflexivity, drawing upon our conversation to consider what it means for feminist scholars to ‘study up’. We argue that feminist IR conceptions of narratives and the everyday make a valuable contribution to feminist institutionalist understandings of the formal and informal. We also draw attention to the value of postcolonial approaches, and multi-site analysis of international institutions for creating a counter-narrative to hegemonic accounts emerging from both the institutions themselves, and scholars studying them without a critical feminist perspective. In so doing, we draw attention to the salience of considering not just what we study as feminist International Relations scholars but how we study it. Spanish Experiencias feministas de \uabEstudiar a los de arriba\ubb: encuentros con instituciones internacionales Este art\uedculo plantea el argumento de que las relaciones internacionales (RR. II.) feministas pueden fomentar el conocimiento de las instituciones internacionales. Se destila de una mesa redonda denominada Challenges and Opportunities for Feminist IR: Researching Gendered Institutions(Retos y oportunidades para las RR. II. feministas: el estudio de las instituciones marcadas por el g\ue9nero) que tuvo lugar en la convenci\uf3n anual de la Asociaci\uf3n de Estudios Internacionales celebrada en Baltimore en 2017. Aqu\ued, nos sumergimos en la autorreflexi\uf3n, recurriendo a nuestra conversaci\uf3n para dilucidar qu\ue9 significa para los acad\ue9micos feministas \uabestudiar a los de arriba\ubb. Argumentamos que las concepciones feministas de las RR. II. sobre los relatos y lo cotidiano realizan una valiosa contribuci\uf3n a las interpretaciones institucionalistas feministas de lo formal y lo informal. Tambi\ue9n queremos destacar el valor de los enfoques poscoloniales y el an\ue1lisis de m\ufaltiples ubicaciones de las instituciones internacionales para crear un contrarrelato frente a los discursos hegem\uf3nicos que se derivan tanto de las propias instituciones como de los acad\ue9micos que las estudian sin una perspectiva feminista cr\uedtica. Al hacerlo, pretendemos destacar la trascendencia de tener en cuenta no solo lo que estudiamos como acad\ue9micos feministas de Relaciones Internacionales, sino tambi\ue9n c\uf3mo lo estudiamos.Palabras clave: g\ue9nero, instituciones internacionales, relaciones internacionales feministas French Exp\ue9riences f\ue9ministes de \uab studying up \ubb : \uc0 la rencontre des institutions internationalesCet article affirme la n\ue9cessit\ue9 pour l’approche f\ue9ministe des RI de renforcer le savoir en mati\ue8re d’institutions internationales. Il est issu d’une table ronde intitul\ue9e \uab D\ue9fis et opportunit\ue9s pour l’approche f\ue9ministes des RI : Recherche sur les institutions genr\ue9es \ubb ayant eu lieu \ue0 Baltimore en 2017 lors de la convention annuelle de l’International Studies Association. Nous entreprenons ici un travail de r\ue9flexion sur nous-m\ueames \ue0 partir de notre discussion sur la question de savoir ce que \uab study up \ubb signifie pour les chercheurs f\ue9ministes. Nous soutenons que les conceptions f\ue9ministes des r\ue9cits et du quotidien dans les RI contribuent positivement \ue0 une compr\ue9hension f\ue9ministe institutionnaliste du formel et de l’informel. Nous mettons \ue9galement en exergue la valeur des approches postcoloniales et de l’analyse sur plusieurs sites des institutions internationales dans la cr\ue9ation d’un r\ue9cit alternatif aux r\ue9cits h\ue9g\ue9moniques provenant \ue0 la fois des institutions elles-m\ueames et des chercheurs qui les \ue9tudient sans cadre d’analyse critique f\ue9ministe. Nous attirons ainsi l’attention sur l’importance pour nous, en tant que sp\ue9cialistes des relations internationales sous un angle f\ue9ministe, de bien r\ue9fl\ue9chir non seulement \ue0 l’objet de nos recherches, mais \ue9galement \ue0 la mani\ue8re dont nous effectuons ces recherches.Mots-cl\ue9s : genre, institutions internationales, relations internationales f\ue9ministes

The ultraviolet B inflammation model: postinflammatory hyperpigmentation and validation of a reduced UVB exposure paradigm for inducing hyperalgesia in healthy subjects

Background Pain models are commonly used in drug development to demonstrate analgesic activity in healthy subjects and should therefore not cause long-term adverse effects. The ultraviolet B (UVB) model is a model for inflammatory pain in which three times the minimal erythema dose (3MED) is typically applied to induce sensitization. Based on reports of long-lasting postinflammatory hyperpigmentation (PIH) associated with 3MED, it was decided to investigate the prevalence of PIH among subjects who were previously exposed to 3MED at our research centre. In addition, re-evaluation of the UVB inflammation model using a reduced exposure paradigm (2MED) was performed in healthy subjects. Methods In the first study, all 142 subjects previously exposed to 3MED UVB were invited for a clinical evaluation of PIH. In the second study, 18 healthy subjects were exposed to 2MED UVB, and heat pain detection threshold (PDT) and PIH were evaluated. Results In total, 78 of the 142 subjects responded. The prevalence of PIH among responders was 53.8%. In the second study, we found a significant and stable difference in PDT between UVB-exposed and control skin 3 hr after irradiation; 13 hr post-irradiation, the least squares mean estimate of the difference in PDT ranged from -2.6 degrees C to -4.5 degrees C (p < 0.0001). Finally, the prevalence of PIH was lower in the 2MED group compared to the 3MED group. Conclusions The 3MED model is associated with a relatively high prevalence of long-lasting PIH. In contrast, 2MED exposure produces stable hyperalgesia and has a lower risk of PIH and is therefore recommended for modelling inflammatory pain. Significance Postinflammatory hyperpigmentation is an unwanted long-term side effect associated with the UVB inflammation model using the 3x minimal erythema dose (3MED) paradigm. In contrast, using a 2MED paradigm results in hyperalgesia that is stable for 36 hr and has a lower risk of inducing postinflammatory hyperpigmentation.Drug Delivery Technolog

Chiral Transparency

Color transparency is the vanishing of initial and final state interactions, predicted by QCD to occur in high momentum transfer quasielastic nuclear reactions. For specific reactions involving nucleons, the initial and final state interactions are expected to be dominated by exchanges of pions. We argue that these interactions are also suppressed in high momentum transfer nuclear quasielastic reactions; this is ``chiral transparency". We show that studies of the $e ^3He \to e'\Delta^{++} nn$ reaction could reveal the influence of chiral transparency.Comment: 20 pages, three figures available by fax from [email protected]; submitted to Phys. Rev.

Clinical, Cellular, and Molecular Effects of Corticosteroids on the Response to Intradermal Lipopolysaccharide Administration in Healthy Volunteers

The intradermal lipopolysaccharide (LPS) challenge in healthy volunteers has proven to be a valuable tool to study local inflammation in vivo. In the current study the inhibitory effects of oral and topical corticosteroid treatment on intradermal LPS responses were evaluated to benchmark the challenge for future investigational drugs. Twenty-four healthy male volunteers received a two-and-a-half-day twice daily (b.i.d.) pretreatment with topical clobetasol propionate 0.05% and six healthy volunteers received a two-and-a-half-day b.i.d. pretreatment with oral prednisolone at 0.25 mg/kg body weight per administration. Participants received one injection regimen of either 0, 2, or 4 intradermal LPS injections (5 ng LPS in 50 µL 0.9% sodium chloride solution). The LPS response was evaluated by noninvasive (perfusion, skin temperature, and erythema) and invasive assessments (cellular and cytokine responses) in suction blister exudate. Both corticosteroids significantly suppressed the clinical inflammatory response (erythema P = 0.0001 for clobetasol and P = 0.0016 for prednisolone; heat P = 0.0245 for clobetasol, perfusion P < 0.0001 for clobetasol and P = 0.0036 for prednisolone). Clobetasol also significantly reduced the number of monocytes subsets, dendritic cells, natural killer cells, and T cells in blister exudate. A similar effect was observed for prednisolone. No relevant corticosteroid effects were observed on the cytokine response to LPS. We successfully demonstrated that the anti-inflammatory effects of corticosteroids can be detected using our intradermal LPS challenge model, validating it for evaluation of future investigational drugs, as an initial assessment of the anti-inflammatory effects of such compounds in a minimally invasive manner

Report on short-term side effects of treatments with 177Lu- octreotate in combination with capecitabine in seven patients with gastroenteropancreatic neuroendocrine tumours

Purpose: Treatment with the radiolabelled somatostatin analogue177Lu-octreotate results in tumour remission in 47% of patients with gastroenteropancreatic neuroendocrine tumours. Adding capecitabine to177Lu-octreotate, as a radio-sensitiser, may enhance these anti-tumour effects. We now present the short-term toxicity profile of this novel combination. Methods: Seven patients were treated with 7.4 GBq177Lu-octreotate and capecitabine (1650 mg/m2per day) for 2 weeks with an intended number of four cycles. Toxicity, and especially haematological and renal parameters, were monitored on a weekly basis for the first two cycles and 4 and 6 weeks after subsequent cycles. Results: None of the patients had hand-foot syndrome. One patient had grade 1 stomatitis occurring after one of four cycles. Grade 3 or 4 leukopenia or neutropenia did not occur. One patient had grade 3 anaemia, but none had grade 4 anaemia. One patient had grade 2 thrombocytopenia after the fourth cycle, and one had grade 3 thrombocytopenia. Grade 4 thrombocytopenia did not occur. No significant changes in serum creatinine levels were observed. None of the patients had symptoms of cardiac ischaemia. Conclusions: Treatment with the combination of177Lu-octreotate and capecitabine was feasible and safe considering acute and subacute side effects. We therefore started a randomised, controlled clinical trial to compare this combination with177Lu-octreotate as single agent with regard to anti-tumour effects and side effects

Intradermal lipopolysaccharide challenge as an acute in vivo inflammatory model in healthy volunteers

Aims: Whereas intravenous administration of Toll-like receptor 4 ligand lipopolysaccharide (LPS) to human volunteers is frequently used in clinical pharmacology studies, systemic use of LPS has practical limitations. We aimed to characterize the intradermal LPS response in healthy volunteers, and as such qualify the method as local inflammation model for clinical pharmacology studies. Methods: Eighteen healthy male volunteers received 2 or 4 intradermal 10 ng LPS injections and 1 saline injection on the forearms. The LPS response was evaluated by noninvasive (perfusion, skin temperature and erythema) and invasive assessments (cellular and cytokine responses) in skin biopsy and blister exudate. Results: LPS elicited a visible response and returned to baseline at 48 hours. Erythema, perfusion and temperature were statistically significant (P < .0001) over a 24-hour time course compared to saline. The protein response was dominated by an acute interleukin (IL)-6, IL-8 and tumour necrosis factor response followed by IL-1β, IL-10 and interferon-γ. The cellular response consisted of an acute neutrophil influx followed by different monocyte subsets and dendritic cells. Discussion: Intradermal LPS administration in humans causes an acute, localized and transient inflammatory reaction that is well-tolerated by healthy volunteers. This may be a valuable inflammation model for evaluating the pharmacological activity of anti-inflammatory investigational compounds in proof of pharmacology studies

The difference that tenure makes

This paper argues that housing tenures cannot be reduced to either production relations or consumption relations. Instead, they need to be understood as modes of housing distribution, and as having complex and dynamic relations with social classes. Building on a critique of both the productionist and the consumptionist literature, as well as of formalist accounts of the relations between tenure and class, the paper attempts to lay the foundations for a new theory of housing tenure. In order to do this, a new theory of class is articulated, which is then used to throw new light on the nature of class-tenure relations