293 research outputs found
A case study of random field models applied to thin-walled composite cylinders in finite element analysis
Towards improved management of coastal submersion crises - CRISMA-WAVE solution as an example of CRISMA Framework application
Coping with various types of natural or man-made hazards the FP7 SECURITY CRISMA project (http://www.crisrnaprojecteu) has designed and developed an experimental software framework allowing building crisis management simulation application. One of the five pilot applications of CRISMA dealing with preparedness to the coastal submersions was developed and implemented using return of experience of the reference Xynthia storm surge event in the Charente Maritime County in France. The paper addresses the generic CRISMA Framework applicability to simulate mitigation effects of a coastal submersion through CRISMA-Wave implementation of a full modelling cycle. The CRISMA-Wave paradigm reflects user needs for simulation of "what-if" scenarios for short and long-term actions and the paper describes in particular its different components : *Simulation of submersion effects at a range of temporal and spatial scales, *Preparedness Planning, *Assessment of impacts depending on scenarios based on options for managing the inundation risks, *Cascading effects and *Evaluation of damages with comparison of submersion defence scenarios based on cost-benefit and multi criteria analysis
Zn, Cu, Cd and Hg binding to metallothioneins in harbour porpoises <i>Phocoena phocoena</i> from the southern North Sea
Background: Harbour porpoises Phocoena phocoena from the southern North Sea are known to display high levels of Zn and Hg in their tissues linked to their nutritional status (emaciation). The question arises regarding a potential role of metallothioneins (MTs) with regard to these high metal levels. In the present study, metallothionein detection and associated Zn, Cd, Cu and Hg concentrations were investigated in the liver and kidney of 14 harbour porpoises collected along the Belgian coast. Results: Metallothioneins seemed to play a key role in essential metal homeostasis, as they were shown to bind 50% of the total hepatic Zn and 36% of the total hepatic Cu concentrations. Renal MTs also participated in Cd detoxification, as they were shown to bind 56% of the total renal Cd. Hg was mainly found in the insoluble fraction of both liver and kidney. Concomitant increases in total Zn concentration and Zn bound to MTs were observed in the liver, whereas Zn concentration bound to high molecular weight proteins remained constant. Cu, Zn and Cd were accumulated preferentially in the MT fraction and their content in this fraction increased with the amount in the hepatocytosol. Conclusion: MTs have a key role in Zn and Cu homeostasis in harbour porpoises. We demonstrated that increasing hepatic Zn concentration led to an increase in Zn linked to MTs, suggesting that these small proteins take over the Zn overload linked to the poor body condition of debilitated harbour porpoises
Time delays in quasi-periodic pulsations observed during the X2.2 solar flare on 2011 February 15
We report observations of quasi-periodic pulsations (QPPs) during the X2.2
flare of 2011 February 15, observed simultaneously in several wavebands. We
focus on fluctuations on time scale 1-30 s and find different time lags between
different wavebands. During the impulsive phase, the Reuven Ramaty High Energy
Solar Spectroscopic Imager (RHESSI) channels in the range 25-100 keV lead all
the other channels. They are followed by the Nobeyama RadioPolarimeters at 9
and 17 GHz and the Extreme Ultra-Violet (EUV) channels of the Euv
SpectroPhotometer (ESP) onboard the Solar Dynamic Observatory (SDO). The
Zirconium and Aluminum filter channels of the Large Yield Radiometer (LYRA)
onboard the Project for On-Board Autonomy (PROBA2) satellite and the SXR
channel of ESP follow. The largest lags occur in observations from the
Geostationary Operational Environmental Satellite (GOES), where the channel at
1-8 {\AA} leads the 0.5-4 {\AA} channel by several seconds. The time lags
between the first and last channels is up to 9 s. We identified at least two
distinct time intervals during the flare impulsive phase, during which the QPPs
were associated with two different sources in the Nobeyama RadioHeliograph at
17 GHz. The radio as well as the hard X-ray channels showed different lags
during these two intervals. To our knowledge, this is the first time that time
lags are reported between EUV and SXR fluctuations on these time scales. We
discuss possible emission mechanisms and interpretations, including flare
electron trapping
The SWAP EUV Imaging Telescope Part I: Instrument Overview and Pre-Flight Testing
The Sun Watcher with Active Pixels and Image Processing (SWAP) is an EUV
solar telescope on board ESA's Project for Onboard Autonomy 2 (PROBA2) mission
launched on 2 November 2009. SWAP has a spectral bandpass centered on 17.4 nm
and provides images of the low solar corona over a 54x54 arcmin field-of-view
with 3.2 arcsec pixels and an imaging cadence of about two minutes. SWAP is
designed to monitor all space-weather-relevant events and features in the low
solar corona. Given the limited resources of the PROBA2 microsatellite, the
SWAP telescope is designed with various innovative technologies, including an
off-axis optical design and a CMOS-APS detector. This article provides
reference documentation for users of the SWAP image data.Comment: 26 pages, 9 figures, 1 movi
An interactive web-based educational tool improves detection and delineation of Barrett’s esophagus related neoplasia
Background & Aims: Endoscopic detection of early Barrett’s esophagus-related neoplasia (BORN) is a challenge. We aimed to develop a web-based teaching tool for improving detection and delineation of BORN. Methods: We made high-definition digital videos during endoscopies of patients with BORN and non-dysplastic Barrett’s esophagus (NDBE). Three experts superimposed their delineations of BORN lesions on the videos using special tools. In phase 1, 68 general endoscopists from 4 countries assessed 4 batches of 20 videos. After each batch, mandatory feedback compared assessors interpretations with those from experts . These data informed selection of 25 videos for the phase 2 module, which was completed by 121 new assessors from 5 countries. A 5-video test batch was completed before and after scoring of the four 5-video training batches. Mandatory feedback was as in phase 1. Outcome measures were scores for detection, delineation, agreement delineation, and relative delineation of BORN. Results: A linear mixed-effect model showed significant sequential improvement for all 4 outcomes over successive training batches in both phases. In phase 2, median detection rates of BORN in the test batch increased by 30% (P [less than].001) after training. From baseline to the end of the study, there were relative increases in scores of 46% for detection, 129% for delineation, 105% for agreement delineation, and 106% for relative delineation (all P [less than].001). Scores improved independent of assessors’ country of origin or level of endoscopic experience
Torsional Alfven waves in stratified and expanding magnetic flux tubes
The effects of both density stratification and magnetic field expansion on
torsional Alfven waves in magnetic flux tubes are studied. The frequencies, the
period ratio P1/P2 of the fundamental and its first-overtone, and
eigenfunctions of torsional Alfven modes are obtained. Our numerical results
show that the density stratification and magnetic field expansion have opposite
effects on the oscillating properties of torsional Alfven waves.Comment: 13 pages, 7 figures, Accepted for publication in Astrophysics and
Space Scienc
Targeting the latent human cytomegalovirus reservoir for T-cell-mediated killing with virus-specific nanobodies.
Funder: Department of HealthLatent human cytomegalovirus (HCMV) infection is characterized by limited gene expression, making latent HCMV infections refractory to current treatments targeting viral replication. However, reactivation of latent HCMV in immunosuppressed solid organ and stem cell transplant patients often results in morbidity. Here, we report the killing of latently infected cells via a virus-specific nanobody (VUN100bv) that partially inhibits signaling of the viral receptor US28. VUN100bv reactivates immediate early gene expression in latently infected cells without inducing virus production. This allows recognition and killing of latently infected monocytes by autologous cytotoxic T lymphocytes from HCMV-seropositive individuals, which could serve as a therapy to reduce the HCMV latent reservoir of transplant patients
Excitation of standing kink oscillations in coronal loops
In this work we review the efforts that have been done to study the
excitation of the standing fast kink body mode in coronal loops. We mainly
focus on the time-dependent problem, which is appropriate to describe flare or
CME induced kink oscillations. The analytical and numerical studies in slab and
cylindrical loop geometries are reviewed. We discuss the results from very
simple one-dimensional models to more realistic (but still simple) loop
configurations. We emphasise how the results of the initial value problem
complement the eigenmode calculations. The possible damping mechanisms of the
kink oscillations are also discussed
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