Thaumetopoea Pinivora Treitschke, 1834, Thaumetopoidae nou per a la fauna de Catalunya (Lepidoptera)

Se da cuenta del hallazgo en Cataluña (Els Coms de Das, Baixa Cerdanya, Pirineo oriental) de Thaumetopoea pinivora Treitschke, 1834, Thaumetopoeidae nuevo para la región. Se exponent los aspectos más interesantes de su bionomía y se pone al día la distribución de esta especie en la Península Ibérica.Thaumetopoea pinivora Treitschke, 1834, Thaumetopoidae new for Catalonia (Lepidoptera). In this paper the authors report the found in Catalonia (Els Coms de Das, Baixa Cerdanya, Pirineu oriental) of Thaumetopoea pinivora Treitschke, 1834, Thaumetopoeidae new for the area. We expose the more interesting aspects of its bionomy and actualize its distribution in the lberian fauna

<b><i>Topoisomerase 1</i></b> Promoter Variants and Benefit from Irinotecan in Metastatic Colorectal Cancer Patients

Objective: Topoisomerase 1 (topo-1) is an important target for the treatment of metastatic colorectal cancer (CRC). The aim of the present study was to evaluate the correlation between topo-1 single-nucleotide polymorphisms (SNPs) and clinical outcome in metastatic CRC (mCRC) patients. Methods: With the use of specific software (PROMO 3.0), we performed an in silico analysis of topo-1 promoter SNPs; the rs6072249 and rs34282819 SNPs were included in the study. DNA was extracted from 105 mCRC patients treated with FOLFIRI ± bevacizumab in the first line. SNP genotyping was performed by real-time PCR. Genotypes were correlated with clinical parameters (objective response rate, progression-free survival, and overall survival). Results: No single genotype was significantly associated with clinical variables. The G allelic variant of rs6072249 topo-1 SNP is responsible for GC factor and X-box-binding protein transcription factor binding. The same allelic variant showed a nonsignificant trend toward a shorter progression-free survival (GG, 7.5 months; other genotypes, 9.3 months; HR 1.823, 95% CI 0.8904-3.734; p = 0.1). Conclusion: Further analyses are needed to confirm that the topo-1 SNP rs6072249 and transcription factor interaction could be a part of tools to predict clinical outcome in mCRC patients treated with irinotecan-based regimens

Indigo (Cat5 & Sep5) System mechanical thrombectomy for acute mesenteric ischemia: an innovative approach for treatment of a severe but not so infrequent disease

Acute Mesenteric ischemia (AMI) is a severe and commonly underreported disease that has an annual incidence of 0.09-0.2% per patient year. However some studies have shown an increased incidence of AMI after performing an exhaustive analysis of 402 autopsies and surgeries (1970-1982 Malmo, Sweden). All mesenteric ischemia (MI) has and incidence of 12.9 cases of MI/10000 inhabitants/year, 67% thromboembolic SMA occlusion, 16% mesenteric venous thrombosis (MVT), 15% non-occlusive mesenteric ischemia (NOMI) and 2% have indeterminate cause. We present a patient with SMA treated satisfactorily with a new thromboaspiration system

Le smart cities in Francia

The article presents the French approach to smart cities. Unlike other countries (members of the European Union and other nations, such as the United States, India...) that prefer an approach that could be defined “interventionist”, in France there is currently no specific regulatory framework for smart cities, perhaps because local administration is undergoing an extensive reorganization and the role of inter-municipal structures and metropolitan areas (métropoles) is growing. The specificity of the French approach can be identified in the tendency to experiment permanently new forms of collaboration between the public and private sectors. This is certainly due to the centralized industrial fabric and the fact that large companies are holders of the majority of public contracts. Such companies are therefore privileged, long-time partners of local authorities and, on the latter’s behalf manage local public services. Two examples (Lyon and Issy-les-Moulineaux) and the success of their experiments seem to confirm this interpretation

The glucocorticoid PYED-1 disrupts mature biofilms of Candida spp. and inhibits hyphal development in Candida albicans

Invasive Candida infections have become a global public health problem due to the increase of Candida species resistant against antifungal therapeutics. The glucocorticoid PYED-1 (pregnadiene-11-hydroxy-16α,17α-epoxy-3,20-dione-1) has antimicrobial activity against various bacterial taxa. Consequently, it might be considered for the treatment of Candida infections. The antifungal activity of PYED-1 was evaluated against several fungal strains that were representative of the five species that causes the majority of Candida infections—namely, Candida albicans, Candida glabrata, Candida tropicalis, Candida parapsilosis and Candida krusei. PYED-1 exhibited a weak antifungal activity and a fungistatic effect on all five Candida species. On the other hand, PYED-1 exhibited a good antibiofilm activity, and was able to eradicate the preformed biofilms of all Candida species analyzed. Moreover, PYED-1 inhibited germ tube and hyphae formation of C. albicans and reduced adhesion of C. albicans to abiotic surfaces by up to 30%

Polarimetry of Li-rich giants

Protoplanetary nebulae typically present non-spherical envelopes. The origin of such geometry is still controversial. There are indications that it may be carried over from an earlier phase of stellar evolution, such as the AGB phase. But how early in the star's evolution does the non-spherical envelope appear? Li-rich giants show dusty circumstellar envelopes that can help answer that question. We study a sample of fourteen Li-rich giants using optical polarimetry in order to detect non-spherical envelopes around them. We used the IAGPOL imaging polarimeter to obtain optical linear polarization measurements in V band. Foreground polarization was estimated using the field stars in each CCD frame. After foreground polarization was removed, seven objects presented low intrinsic polarization (0.19 - 0.34)% and two (V859 Aql and GCSS 557) showed high intrinsic polarization values (0.87 - 1.16)%. This intrinsic polarization suggests that Li-rich giants present a non-spherical distribution of circumstellar dust. The intrinsic polarization level is probably related to the viewing angle of the envelope, with higher levels indicating objects viewed closer to edge-on. The correlation of the observed polarization with optical color excess gives additional support to the circumstellar origin of the intrinsic polarization in Li-rich giants. The intrinsic polarization correlates even better with the IRAS 25 microns far infrared emission. Analysis of spectral energy distributions for the sample show dust temperatures for the envelopes tend to be between 190 and 260 K. We suggest that dust scattering is indeed responsible for the optical intrinsic polarization in Li-rich giants. Our findings indicate that non-spherical envelopes may appear as early as the red giant phase of stellar evolution.Comment: to be published in A&A, 15 pages, 10 figures. Fig. 3 is available in ftp://astroweb.iag.usp.br/pub/antonio/4270/4270.fig3.pd

Remote Sensing: Useful Approach for Crop Nitrogen Management and Sustainable Agriculture

Soil fertility is among the most important criteria that affect crop yield and quality. Nitrogen stress due to the low soil fertility and the lack of nitrogen availability is a major factor limiting the crop productivity in arid and semiarid environments, where fertilization is not optimized in terms of timing and quantity. Managing nitrogen fertilization is one of the most important criteria in the precision agriculture, which helps to improve crop production, environment conditions, and farmer’s economy. It is very important to apply N fertilizers with efficient methods allowing to the nutrient use efficiency and avoiding nitrogen losses and environment contamination. Nowadays, remote sensing methods using spectral and thermal approaches have been proposed as potential indicators to rapid identification of crop nitrogen status by providing information about vegetation canopy properties across large areas. The use of remote sensing methods to schedule nitrogen fertilization can help farmers to practice a more sustainable agriculture, minimizing risks of losing the harvest by providing an adequate rate of nitrogen when the crops’ needs and at a specific location

Real Decreto del Rey nuestro señor, don Carlos Tercero, (que Dios guarde) en que con su real magnanimidad, y justificada clemencia, se ha servido consignar diez millones de Reales al año, comenzando desde el presente, para ir pagando los creditos, contraidos por la Corona, en el reynado de su augustissimo padre el Sr. Don Phelipe Quinto (que de Dios goze) hasta su total extinción, destinando aora, ademas de esta consignacion, cinquenta millones de reales para repartir promptamente entre todos los interesados, y instruccion, que en su consequencia ha formado de orden de S.M

Creu xil. a l'inici del textCòpia de l'original reimprès a Sevilla el mateix anyLloc i data del text: "Buen-Retiro, veinte y dos de Febrero de mil setecientos y sesenta" signat "El Marquès de Squilace"ReclamsSign.: A2Reial Decret del Rei nostre senyor, don Carles Tercer, (que Déu guardi) en que amb la seva reial magnificència, i justificada clemència, s'ha servit consignar deu milions de Reials l'any, començant des del present, per anar pagant els crèdits, contraguts per la Corona, en el regnat del seu agustíssim pare el Sr. Don Felip Cinquè (que Déu guardi) (….).