Nuclear Physics from lattice QCD at strong coupling

We study numerically the strong coupling limit of lattice QCD with one flavor of massless staggered quarks. We determine the complete phase diagram as a function of temperature and chemical potential, including a tricritical point. We clarify the nature of the low temperature dense phase, which is strongly bound nuclear matter. This strong binding is explained by the nuclear potential, which we measure. Finally, we determine, from this first-principle limiting case of QCD, the masses of atomic nuclei up to A=12 "carbon".Comment: 4 pages, 5 figures; v2: references added, minor changes, published versio

Temporal pattern of Klebsiella pneumoniae carbapenemase (KPC) on surface of an intensive care unit of a large hospital

Background: Carbapenem-resistant Enterobacteriaceae are an increasing cause of healthcare-associated infections worldwide. Patients with infections caused by Klebsiella pneumoniae resistant to carbapenems (KPC) have significant increases in both allcause mortality and 30-day mortality. The aims of this study was to investigate the prevalence of KPC on environmental samples collected during and after an outbreak caused by KPC in an intensive care unit (ICU) of a teaching hospital. Methods: Between 2010 and 2014 we conducted a total of 132 environmental monitoring campaigns from different critical surface of ICU ward in a Teaching Hospital Policlinico Umberto I. Samples were collected on surfaces in patient rooms and health care area. All samples were cultured and K. pneumoniae isolates were identified by standard microbiological techniques. The presumptive colonies were confirmed and tested for antibiotic resistance by an automated system. K. pneumoniae resitant to carbapenems were tested for carbapenemase production by modified Hodge test. Results: A total of 2526 environmental samples were collected from November 2010 to July 2014. Of those, 111 resulted positive for K. pneumoniae while KPC were 95 (85.6% of all K. pneumoniae, 3.8% of total samples). KPC was recovered in all patient rooms with similar proportion (5.1-5.6%) with the exception of patient 6 bed room where it was lower (2.4%). The pathogen was not recovered in rooms dedicated to healthcare personnel and doctors. Among surfaces, the highest proportion of KPC resulted on bedrail (6.8%), more than double than other surfaces. Washbasins had nearly half of samples KPC positive (1.2%). Conclusions: Despite previous studies suggested that environment plays a minor role in the transmission of carbapenem-resistant enterobacteriaceae, our data highlighted that surfaces represents a significant reservoir for KPC possibly supporting transiently contamination of hands of healthcare workers in our ICU. Our results confirm that KPC are more likely found on surfaces closer to the patient than on those situated further away

A cross-sectional study on prevalence and predictors of burnout among a sample of pharmacists employed in pharmacies in Central Italy

Burnout is defined as an occupational phenomenon linked to chronic workplace stress that has not been successfully managed and included among the factors influencing health status or contact with health services. Although several studies were performed for assessing this phenomenon, there is a lack of data on the prevalence of burnout and associated predictors, due to different definitions of the syndrome and heterogeneity of assessment methods. One of the well-known evidences on burnout is related to the highest risk professions, which include policemen, firemen, teachers, psychologists, medical students, nurses, physicians, and other health professionals, such as pharmacists. Objective. The aims of the present study were to (1) assess the occurrence of burnout syndrome among a sample of pharmacists employed in public and private pharmacies located in Rome province (Latium Region; central Italy); (2) evaluate the role of some potential predictors for the development of the syndrome. Materials and Methods. A questionnaire elaborated ad hoc was administered online to 2,000 members of the Association of Professional Pharmacists of Rome and its province and employed in public or private pharmacies. The questionnaire included the 14-item Shirom-Melamed Burnout Measure (SMBM) tool and questions on demographic characteristics and working conditions. Results. Physical exhaustion was the burnout dimension with the highest score; besides, approximately 11% of the studied pharmacists were categorized as having clinically relevant burnout levels (≥4.40). Several of the investigated variables significantly influenced the single burnout dimensions at the univariate analyses; multivariate analyses demonstrated that alcohol consumption and workplace location have a significant independent role on the overall SMBM index, while working time significantly influences clinically relevant burnout level. Conclusions. The results revealed that pharmacists are at risk of burnout, and thus, it is necessary to perform specific preventive intervention for managing this occupational threat

Mean-field calculations of exotic nuclei ground states

We study the predictions of three mean-field theoretical approaches in the description of the ground state properties of some spherical nuclei far from the stability line. We compare binding energies, single particle spectra, density distributions, charge and neutron radii obtained with non-relativistic Hartree-Fock calculations carried out with both zero and finite-range interactions, and with a relativistic Hartree approach which uses a finite-range interaction. The agreement between the results obtained with the three different approaches indicates that these results are more related to the basic hypotheses of the mean-field approach rather than to its implementation in actual calculations.Comment: 16 pages, 12 figures, 2 tables, accepted for publication in Physical Review

Two-nucleon emission in the longitudinal response

The contribution of the two-nucleon emission in the longitudinal response for inclusive electron scattering reactions is studied. The model adopted to perform the calculations is based upon Correlated Basis Function theory but it considers only first order terms in the correlation function. The proper normalization of the wave function is ensured by considering, in addition to the usually evaluated two-point diagrams, also the three-point diagrams. Results for the 12C nucleus in the quasi-elastic region are presented.Comment: 7 pages, 4 Postscript figure

Association between work related stress and health related quality of life: the impact of socio-demographic variables. A cross sectional study in a region of central Italy

The aim of this work is investigate relationship between health-related quality of life and work-related stress and the impact of gender, education level, and age on this relationship. A cross-sectional study was conducted among workers of various setting in Rome and Frosinone. Work-related stress was measured with a demand-control questionnaire and health-related functioning by SF (short form)-12 health survey. There were 611 participants. Men reported high mental composite summary (MCS) and physical composite summary (PCS). In multivariate analysis age, gender (p < 0.001) and job demand (0.045) predicted low PCS. Low MCS predicted poor PCS. Job demand and educational level resulted negatively associated with MCS. In an analysis stratified for age, gender, and educational level, gender and age resulted effect modifier for MCS, gender and education level for PCS. In women increase of decision latitude predict (p = 0.001) an increase in MCS; a low job demand predict high MCS in male (p ≤ 0.001). In younger workers, a lower level of job demand predicted high MCS (<0.001). For PCS, gender and education level resulted effect modifier. In women, high decision latitude predicted higher PCS (p = 0.001) and lower level of job demand results in higher PCS (p ≤ 0.001). Higher educational level resulted predictor of low PCS. Management of risk about work-related stress should consider socio-demographic factors

Relativistic analysis of the 208Pb(e,e'p)207Tl reaction at high momentum

The recent 208Pb(e,e'p)207Tl data from NIKHEF-K at high missing momentum (p_m>300 MeV/c) are compared to theoretical results obtained with a fully relativistic formalism previously applied to analyze data on the low missing momentum (p_m < 300 MeV/c) region. The same relativistic optical potential and mean field wave functions are used in the two p_m-regions. The spectroscopic factors of the various shells are extracted from the analysis of the low-p_m data and then used in the high-p_m region. In contrast to previous analyses using a nonrelativistic mean field formalism, we do not find a substantial deviation from the mean field predictions other than that of the spectroscopic factors, which appear to be consistent with both low- and high-p_m data. We find that the difference between results of relativistic and nonrelativistic formalisms is enhanced in the p_m<0 region that will be interesting to explore experimentally.Comment: 12 pages, LaTeX+Revtex, included 3 postscript figures. To appear in the Physical Review C (Rapid Communications

Pre-chamber ignition mechanism: Experiments and simulations on turbulent jet flame structure

This work investigates the effects of premixed combustion kinematics in pre-chamber volumes on the development of emitted hot jets from the igniter. The effects of fuel type, orifice diameter, and ignition location are evaluated experimentally, with high-speed OH* and CH* chemiluminescence imaging, and computationally with Large-Eddy Simulations (LES). The imaging experiments allowed for simultaneous viewing of combustion processes within a quartz chamber and of the developing jet flow. Results from these experiments provided insight on the temporal evolution of the jet relative to the growth of an ignited kernel within the chamber, as well as information on the emission or lack of emission of radical species from the chamber. Computational results provided data on the temporal behavior of the pressure within the chamber and profiles of the high velocity flow through the orifice. These results, combined, have shown that dependent on the strain rate and effective orifice size, local quenching of radical species at the orifice occurs which fundamentally change whether hot products, reactive layers, or both are present in the turbulent jet emission. The dynamic structure and composition of the turbulent jet controls its relevance as an effective ignition source

Pseudo-outbreak of Mycobacterium gordonae in a teaching hospital: importance of strictly following decontamination procedures and emerging issues concerning sterilization

Aim of this study was to investigate a pseudo-outbreak of Mycobacterium gordonae analyzing isolates detected from clinical and environmental samples. Mycobacterium gordonae was detected in 7 out of 497 broncho-alveolar lavage (BAL) samples after bronchoscopy procedure in patients admitted to a teaching hospital between January and April 2013. During this pseudo-outbreak clinical, epidemiological, environmental and molecular investigations were performed. None of the patients met the criteria for non-tuberculous mycobacterial (NTM) lung disease and were treated for M. gordonae lung disease. Environmental investigation revealed M. gordonae in 3 samples: in tap water and in the water supply channel of the washer disinfector. All the isolates were subjected to genotyping by pulsed-field gel electrophoresis (PFGE). The PFGE revealed that only patients' isolates presented the same band pattern but no correlation with the environmental strain was detected. Surveillance of the outbreak and the strict adherence to the reprocessing procedure and its supplies resulted afterwards in no detection of M. gordonae in clinical respiratory samples. Clinical surveillance of patients was crucial to establish the start of NTM treatment. Regular screening of tap water and endoscopic equipment should be adopted to compare the clinical strains with the environmental ones when an outbreak occurs

Human exposure to antibiotic resistant-Escherichia coli through irrigated lettuce

Antibiotic resistant bacteria (ARB) have been found on fresh fruit and vegetables globally. These types of ARB infections are spreading rapidly and are a major human health threat. A quantitative human exposure assessment model was created using scenario analysis to investigate the potential human exposure to antibiotic resistant Escherichia coli (AR-E. coli) through the consumption of lettuce irrigated with surface water. Scientific literature and site specific data were collected to model each process from farm to fork to calculate the concentration of AR-E. coli on the lettuce at the point of human consumption. The processes examined were the adhesion, colonisation and viability of bacteria on the lettuce; the effect of different post-harvest cleaning processes; the effect of consuming the lettuce before, on or after the expiry date; and the effect of the consumer washing the lettuce. The results show the mean human exposure levels ranged between 1.00 × 10−2 and 1.35 × 106 colony forming units (CFU) of AR-E. coli per 100 g of surface water irrigated lettuce for the different scenarios investigated. The mean probability of illness from consuming 100 g of lettuce contaminated with potential pathogenic antibiotic-sensitive E. coli was between 1.46 × 10−9 to 1.88 × 10−2. A back calculation revealed that in order for the EC No 1441/2007 regulation to be exceeded (≥1000 CFU/g of E. coli on lettuce at the manufacturing stage), the mean contamination levels required in the irrigation water would need to be 2.7, 3.1 or 4.8 log CFU/ml using the post-harvest treatments of washing with water, rapid cooling with water and washing with a chlorine solution respectively. The information generated from this model could help to set guidelines for producers on maximum permissible AR-E. coli contamination levels in irrigation water and provides recommendations on the best post-harvest treatment to use. Keywords: Antibiotic resistance, Escherichia coli, Irrigation, Human exposure, Lettuc