Mesoscopic continuous and discrete channels for quantum information transfer

We study the possibility of realizing perfect quantum state transfer in mesoscopic devices. We discuss the case of the Fano-Anderson model extended to two impurities. For a channel with an infinite number of degrees of freedom, we obtain coherent behavior in the case of strong coupling or in weak coupling off-resonance. For a finite number of degrees of freedom, coherent behavior is associated to weak coupling and resonance conditions

Double dot chain as a macroscopic quantum bit

We consider an array of N quantum dot pairs interacting via Coulomb interaction between adjacent dots and hopping inside each pair. We show that at the first order in the ratio of hopping and interaction amplitudes, the array maps in an effective two level system with energy separation becoming exponentially small in the macroscopic (large N) limit. Decoherence at zero temperature is studied in the limit of weak coupling with phonons. In this case the macroscopic limit is robust with respect to decoherence. Some possible applications in quantum information processing are discussed.Comment: Phys. Rev. A (in press

Early use of abiraterone and radium-223 in metastatic prostate cancer

[No abstract available

High-dose chemotherapy in a patient with coronavirus disease (COVID-19)

none5noopenDe Giorgi U.; Casadei C.; Bronte G.; Altini M.; Martinelli G.De Giorgi, U.; Casadei, C.; Bronte, G.; Altini, M.; Martinelli, G

Therapeutic challenges for cisplatin-resistant ovarian germ cell tumors

The majority of patients with advanced ovarian germ cell cancer are treated by cisplatin-based chemotherapy. Despite adequate first-line treatment, nearly one third of patients relapse and almost half develop cisplatin-resistant disease, which is often fatal. The treatment of cisplatin-resistant disease is challenging and prognosis remains poor. There are limited data on the efficacy of specific chemotherapeutic regimens, high-dose chemotherapy with autologous progenitor cell support and targeted therapies. The inclusion of patients in clinical trials is strongly recommended, especially in clinical trials on the most frequent male germ cell tumors, to offer wider therapeutic opportunities. Here, we provide an overview of current and potential new treatment options including combination chemotherapy, high-dose chemotherapy and molecular targeted therapies, for patients with cisplatin-resistant ovarian germ cell tumors