Aborto inseguro: determinantes sociais e iniquidades em saúde em uma população vulnerável, São Paulo, Brasil

This cross-sectional population-based study in a peripheral low-income community in São Paulo, Brazil, aimed to estimate the prevalence of unsafe abortion and identify the socio-demographic characteristics associated with it and its morbidity. The article discusses the study's results, based on univariate and multiple multinomial logistic regression analyses. The final regression models included: age at first intercourse 2 sex partners in the previous year (OR = 3.63); more live born children than the woman's self-reported ideal number (OR = 3.09); acceptance of the abortion due to insufficient economic conditions (OR = 4.07); black ethnicity/color (OR = 2.67); and low schooling (OR = 2.46), all with p 2 (OR = 3,63); número de filhos nascidos vivos > ideal (OR = 3,09); aceitação do aborto por falta de condições econômicas (OR = 4,07); etnia negra/cor preta (OR = 2,67); e escolaridade baixa (OR = 2,46), todos com p < 0,05. Foi utilizada na discussão uma abordagem voltada aos determinantes sociais da saúde, segundo conceito e modelo adotados pela WHO, e às iniquidades em saúde por esses geradas na ocorrência do aborto inseguro. Verificou-se que o aborto inseguro e características sociodemográficas são influenciados pelos determinantes sociais da saúde descritos, gerando nessa população iniquidades em saúde de proporções diversas.Universidade Federal de São Paulo (UNIFESP)UNIFESPSciEL

Epidemiology of unsafe abortion in a poverty stricken environment Favela Inajar de Souza, São Paulo, Brazil

This article compares the results of a survey carried out recently in a poverty stricken environment in São Paulo, Brazil - a country where abortion is illegal in most circumstances- to data from Cuba - where abortion is safe and legal, and data registries are reliable. A cross-sectional survey was conducted in a community in the north side of the city, called Favela Inajar de Souza, with the purpose of estimating the frequency of unsafe, clandestine abortions and identifying socio-demographic characteristics and morbidity related to abortion in a poor population. All women aged 15 to 54 years that lived in this community (Census) were interviewed for this survey. The Chi-Square Test and the Fisher exact test were used for categorical variables, and analysis of variance was used for numeric variables. Throughout the analysis, the statistical significance level of 5% (p<0.05) was adopted. A high number of unsafe abortions and a high rate of post-abortion complications were detected in the studied population - the community of Favela Inajar. With regard to induced abortions, the only common features between the two populations were age and civil status. As opposed to what happens in Cuba, the analysis of the data from Favela Inajar shows that there were statistically significant associations between unsafe abortion and: income, educational level, internal migration and ethnicity. These findings indicate that this population is particularly vulnerable to unsafe abortion in face of the several forms of structural violence present in Brazil, which produce social inequity. The performance of safe and legal abortion, as is the case in Cuba, would change this scenario. Legalization of abortion in Brazil would mostly benefit poor women.Procurou-se, neste trabalho, comparar os Resultados de Pesquisa recente, realizada em São Paulo, Brasil, país em que o aborto é ilegal em quase todas as circunstâncias, com dados referentes a Cuba, país onde o aborto é legal e seguro, dispondo de registros confiáveis. Essa pesquisa foi sediada em uma comunidade da Zona Norte da cidade de São Paulo, Favela Inajar de Souza: um estudo transversal que teve por objetivo estimar a freqüência de Abortos Inseguros, bem como determinar as características sociodemográficas e a morbidade associadas a tal ocorrência, em uma população em situação de pobreza. Foram entrevistadas todas as mulheres entre 15 e 54 anos residentes na comunidade (Censo). Na análise dos dados foram empregados o teste exato de Fisher e o teste qui-quadrado para as variáveis categóricas, e a análise de variância (ANOVA) para as variáveis numéricas. Em toda a análise adotou-se um nível de significância de 5%, com p < 0,05. Encontrou-se, na população estudada, Favela Inajar, um alto número de abortos inseguros e alta porcentagem de complicações pós-aborto. Em comum com Cuba, quanto ao Aborto Induzido foi observada semelhança de perfil somente em relação à Idade e ao Estado Civil. Nos Resultados foram constatadas também - contrariamente ao que ocorre em Cuba - associações estatisticamente significativas entre Aborto Inseguro e Renda/Escolaridade (baixas), Aborto Inseguro e Etnia/Cor, Aborto Inseguro e Não Apoio do Parceiro, e Aborto Inseguro e Migração Interna - o que torna essa população especialmente vulnerável ao aborto inseguro frente às violências estruturais, geradoras de iniqüidade, vigentes no Brasil. O aborto legal e seguro, tal como em Cuba, transformaria essa realidade. A legalização do aborto beneficiaria, sobretudo, as mulheres pobres.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de Medicina PreventivaUNIFESP, EPM, Depto. de Medicina PreventivaSciEL

Prevalência e características sociodemográficas de mulheres com aborto provocado em uma amostra da população da cidade de São Paulo, Brasil

Objectives:This study aims at estimating the prevalence of women with induced abortion among women of childbearing age (15-49 years) who had any previous pregnancy, in the city of São Paulo, Brazil, in the last quarter of 2008, and identifying the sociodemographic characteristics (SC) associated with it. Methods:A cross-sectional survey was carried out. The dependent variable was dichotomized as: no abortion and induced abortion. The independent variables were: age, paid work/activity, familial monthly income, schooling, marital status, contraceptive use and number of live births. Statistical analysis was performed using log-binomial regression models with approximation of Poisson to estimate the prevalance ratios (PR). Results:Of all women with any previous pregnancy (n = 683), 4.5% (n = 31) reported induced abortion. The final multivariate model showed that having now between 40 and 44 years (PR = 2.76, p = 0.0043), being single (PR = 2.79, p = 0.0159), having 5 or more live births (PR = 3.97, p = 0.0013), current oral contraception or IUD use (PR = 2.70, p = 0.454) and using a non effective (or of low efficacy) contraceptive method (PR = 4.18, p = 0.0009) were sociodemographic characteristics associated with induced abortion in this population. Conclusions:Induced abortion seems to be used to limit fertility, more precisely after having reached the desired number of children. The inadequate use or non-use of effective contraceptive methods, and / or the use of contraceptivenon effective, exposed also the women to the risk of unintended pregnancies and, therefore, induced abortions. In addition, when faced with a pregnancy, single women were more likely to have an abortion than married women.Objetivos:O presente estudo busca estimar a prevalência de mulheres com aborto provocado dentre as mulheres em idade fértil (15 a 49 anos de idade) que apresentaram alguma gestação prévia, residentes na cidade de São Paulo, Brasil, no último trimestre de 2008, bem como identificar essa ocorrência em função de algumas características sociodemográficas (CSD).Métodos:Trata-se de um estudo transversal. A variável dependente aborto foi dicotomizada em: aborto provocado (AP) e nenhum aborto (NA). As variáveis independentes utilizadas foram: idade, atividade remunerada, renda mensal familiar, escolaridade, estado conjugal, uso de método(s) contraceptivo(s) e número de filhos nascidos vivos. A análise estatística foi realizada por meio de modelos de regressão log-binomial com aproximação de Poisson para avaliar as razões de prevalência (RP).Resultados:Dentre o total de mulheres com alguma gestação prévia (n = 683), 4,5% (n = 31) declararam algum AP. O modelo log-binomial final mostrou que idade atual entre 40 e 44 anos de idade (RP = 2,76; p = 0,0043), estado conjugal solteira (RP = 2,79; p = 0,0159), número de filhos nascidos vivos igual ou maior que 5 (RP = 3,97; p = 0,0013, uso de contraceptivo não eficaz ou de baixa eficácia (RP = 4,18; p = 0,0009) e uso atual de contraceptivo oral ou dispositivo intrauterino (RP = 2,70; p = 0,454) foram as características que se apresentaram mais fortemente associadas à ocorrência de AP entre as mulheres dessa população.Conclusões:O aborto provocado é utilizado para limitar a fecundidade, mais precisamente após atingir-se o número desejado de filhos. O uso inadequado, ou o não-uso, de contraceptivos eficazes e/ou a utilização de contraceptivos não eficazes, ou de baixa eficácia, também promovem a resolução pelo aborto, assim como o fato de as mulheres solteiras enfrentarem uma gestação sozinhas.Universidade Federal de São Paulo (UNIFESP) Department of Preventive MedicineCentro Universitário de GuaxupéUNIFESP, Department of Preventive MedicineSciEL

Saúde Reprodutiva, fecundidade e aborto provocado: análise de seis inquéritos populacionais realizados em São Paulo, Brasil

O Aborto Inseguro é, ainda, um grave problema de Saúde Pública e sua solução, um desafio a exigir medidas urgentes que passam, fatalmente, pelo processo de descriminalização do aborto. Conhecer o perfil das mulheres que recorrem ao aborto provocado, especialmente ao clandestino, inseguro, é de suma importância tanto para a área de Saúde Pública, em particular para a Saúde Reprodutiva, quanto para a área de Demografia. A partir da análise de 6 (seis) inquéritos populacionais, conduzidos em populações diferentes quanto à renda e quanto às características sociodemográficas, em São Paulo, nos últimos anos, as autoras procuram aproximar-se desse perfil.Unsafe abortion is still a major public health issue and its solution is a challenge, implicating in the enforcement of urgent measures which necessarily include the decriminalization of abortion. The knowledge of the profile of women who recourse to induced abortion, especially the ones who are submitted to clandestine, unsafe abortions, is essential for the areas of Public Health and Demography. The authors intend, in this study, to outline this profile by analyzing 6 (six) population surveys, conducted in samples of women living in São Paulo, who had distinct income and sociodemographic characteristics

Impact of Rehabilitation on Breast Cancer Related Fatigue: A Pilot Study

Breast cancer fatigue (BCF) is a complex and multidimensional condition characterized by a persistent sense of physical and/or mental stiffness, resulting in a substantial impairment of health-related quality of life in breast cancer survivors. Aim of this prospective cohort study was to evaluate the feasibility and the effectiveness of a 4-week rehabilitation protocol on BCF, muscle mass, strength, physical performance, and quality of life in breast cancer (BC) survivors. We recruited adult BC women with a diagnosis of BCF, according to the International Classification of Diseases 10 criteria, referred to the Outpatient Service for Oncological Rehabilitation of a University Hospital. All participants performed a specific physical exercise rehabilitative protocol consisting of 60-min sessions repeated 2 times/week for 4 weeks. All outcomes were evaluated at the baseline (T0), at the end of the 4-week rehabilitation treatment (T1), and at 2 months follow up (T2). The primary outcome measure was the Brief Fatigue Inventory (BFI); secondary outcomes included: Fat-Free Mass and Fat Mass, assessed by Bioelectrical Impedance Analysis (BIA); Hand Grip Strength Test (HGS); Short Physical Performance Battery (SPPB); 10-meter walking test (10 MWT); 6-min walking test (6 MWT); European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ\u2013C30). Thirty-six women (mean age: 55.17 \ub1 7.76 years) were enrolled in the study. Significant reduction of BCF was observed both after the 4-week rehabilitation treatment (T1) (BFI: 5.4 \ub1 1.6 vs. 4.2 \ub1 1.7; p = 0.004) and at the follow-up visit (T2) (BFI: 5.4 \ub1 1.6 vs. 4.4 \ub1 1.6; p = 0.004). Moreover, significant differences (p < 0.001) HGS, SPPB, 10 MWT, 6 MWT, and EORTC QLQ-C30 were found at T1, while at T2 all the outcome measures were significantly different (p < 0.05) from the baseline. The rehabilitation protocol seemed to be feasible, safe, and effective in reducing BCF, improving muscle mass and function, and improving HRQoL in a cohort of BC survivors. The results of this study could improve awareness of this underestimated disease, suggesting the definition of a specific therapeutic exercise protocol to reduce BCF

Genetic predisposition to hemophagocytic lymphohistiocytosis: Report on 500 patients from the Italian registry.

BACKGROUND: Hemophagocytic lymphohistiocytosis (HLH) is a rare life-threatening disease affecting mostly children but also adults and characterized by hyperinflammatory features. A subset of patients, referred to as having familial hemophagocytic lymphohistiocytosis (FHL), have various underlying genetic abnormalities, the frequencies of which have not been systematically determined previously. OBJECTIVE: This work aims to further our understanding of the pathogenic bases of this rare condition based on an analysis of our 25 years of experience. METHODS: From our registry, we have analyzed a total of 500 unselected patients with HLH. RESULTS: Biallelic pathogenic mutations defining FHL were found in 171 (34%) patients; the proportion of FHL was much higher (64%) in patients given a diagnosis during the first year of life. Taken together, mutations of the genes PRF1 (FHL2) and UNC13D (FHL3) accounted for 70% of cases of FHL. Overall, a genetic diagnosis was possible in more than 90% of our patients with FHL. Perforin expression and the extent of degranulation have been more useful for diagnosing FHL than hemophagocytosis and the cytotoxicity assay. Of 281 (56%) patients classified as having "sporadic" HLH, 43 had monoallelic mutations in one of the FHL-defining genes. Given this gene dosage effect, FHL is not strictly recessive. CONCLUSION: We suggest that the clinical syndrome HLH generally results from the combined effects of an exogenous trigger and genetic predisposition. Within this combination, different weights of exogenous and genetic factors account for the wide disease spectrum that ranges from HLH secondary to severe infection to FHL.Supported by grants from Associazione Italiana Ricerca Istiocitosi (AIRI), Associazione Ciemmeesse-Girotondo per il Meyer, Ministero della Salute (Bando Malattie Rare RF-TOS-2008-1219488), and the Seventh Framework Programme (FP7) of the European Commission (“FIGHT-HLH” Project no. 306124 to M.A.). Disclosure of potential conflict of interest: D. Pende receives royalties paid to her institution. G. M. Griffiths has received research support from the Wellcome Trust. L. Luzzatto is on the Alexion Pharmaceuticals SAB and has received consultancy fees from GlaxoSmithKline.This is the final version of the article. It first appeared from Elsevier via http://dx.doi.org/10.1016/j.jaci.2015.06.04

AIRO Breast Cancer Group Best Clinical Practice 2022 Update

Introduction: Breast cancer is the most common tumor in women and represents the leading cause of cancer death. Radiation therapy plays a key-role in the treatment of all breast cancer stages. Therefore, the adoption of evidence-based treatments is warranted, to ensure equity of access and standardization of care in clinical practice.Method: This national document on the highest evidence-based available data was developed and endorsed by the Italian Association of Radiation and Clinical Oncology (AIRO) Breast Cancer Group.We analyzed literature data regarding breast radiation therapy, using the SIGN (Scottish Intercollegiate Guidelines Network) methodology (www.sign.ac.uk). Updated findings from the literature were examined, including the highest levels of evidence (meta-analyses, randomized trials, and international guidelines) with a significant impact on clinical practice. The document deals with the role of radiation therapy in the treatment of primary breast cancer, local relapse, and metastatic disease, with focus on diagnosis, staging, local and systemic therapies, and follow up. Information is given on indications, techniques, total doses, and fractionations.Results: An extensive literature review from 2013 to 2021 was performed. The work was organized according to a general index of different topics and most chapters included individual questions and, when possible, synoptic and summary tables. Indications for radiation therapy in breast cancer were examined and integrated with other oncological treatments. A total of 50 questions were analyzed and answered.Four large areas of interest were investigated: (1) general strategy (multidisciplinary approach, contraindications, preliminary assessments, staging and management of patients with electronic devices); (2) systemic therapy (primary, adjuvant, in metastatic setting); (3) clinical aspects (invasive, non-invasive and micro-invasive carcinoma; particular situations such as young and elderly patients, breast cancer in males and cancer during pregnancy; follow up with possible acute and late toxicities; loco-regional relapse and metastatic disease); (4) technical aspects (radiation after conservative surgery or mastectomy, indications for boost, lymph node radiotherapy and partial breast irradiation).Appendixes about tumor bed boost and breast and lymph nodes contouring were implemented, including a dedicated web application. The scientific work was reviewed and validated by an expert group of breast cancer key-opinion leaders.Conclusions: Optimal breast cancer management requires a multidisciplinary approach sharing therapeutic strategies with the other involved specialists and the patient, within a coordinated and dedicated clinical path. In recent years, the high-level quality radiation therapy has shown a significant impact on local control and survival of breast cancer patients. Therefore, it is necessary to offer and guarantee accurate treatments according to the best standards of evidence-based medicine