A case study for spacegate point-to-point transportation: Evaluation of a reference end-to-end mission operations and assessment of the associated safety aspects

The ALTEC-conducted Spacegate feasibility study addresses the opportunities offered by the sub-orbital flight with special emphasis to future generation transportation. Pursuing the same systemic methodology of the initial Spacegate definition activities, this paper focuses on some specific aspects of suborbital operations and outlines a top level end-to-end operating cycle for a reference suborbital mission spanning from pre-flight, to flight, re-entry and post landing operations and associated Ground Segment. Special focus is given to identification of suitable locations in Italy for suborbital operations, and to liftoff and re-entry phases; the results of specific simulations are also reported, showing some lift off options and the feasibility of the spiral shaped descent maneuver that improves the pilot controllability of the vehicle during the re-entry phase. Further, this paper outlines within the selected reference mission, the main safety aspects considered as driving factors in planning and implementing future generation transportation; areas such as launch/landing range and relevant risk management/mitigation policies, as well as selection of safety driving criteria in the definition of trajectories and space transition corridors, and capabilities to monitor the vehicle ascent and re-entry will be assessed. Safety regulations will also be evaluated to protect launch range, drive spaceport site selection and consequently the ability of the spaceport to accommodate large numbers of passengers and participants, as well as a number of simultaneous operations such as training, vehicle integration tasks, and passenger preparation for flight. For human flight in general, and in particular for commercial point to point activities at this early stage, it is vital to minimize risk since a fatal accident at the very beginning of flights will put the entire business in jeopardy. The regulatory challenges with regards to safety will also be outlined in this paper, related to executing Spacegate activities in Europe and collaborations with the involved Agencies in the USA and Europe (FAA, ENAC, ENAV, SESAR, EASA) will be explored; in particular, some initiatives have already been started, that include active ALTEC participation to the IAASS Space Safety Technical Committee (SSTC) that was created to contribute to the advancement of the Safety in the area of the "Commercial Suborbital Flight"

Impact of sarcopenia on outcomes after pancreatectomy for malignancy

Background: Sarcopenia, which is a subclinical loss of skeletal muscle mass as measured by cross-sectional imaging, is commonly observed in patients with malignancy. Few studies have examined the association between the presence of sarcopenia and outcome following surgery. The aim of this study is to evaluate the prevalence of sarcopenia and to investigate its impact on short- and long-term outcomes in patients who underwent pancreatectomy for malignancy. Materials and Methods: A retrospective review of a pancreatectomy database was performed. Skeletal muscle index (SMI) was measured on preoperative cross-sectional imaging in 144 patients undergoing pancreatectomy for cancer between 2007 and 2014. Sarcopenia was defined, according to the international consensus, as an SMI <52.4 cm2 /m2 and <38.9 cm2 /m2 for men and women respectively. The prevalence and impact of sarcopenia on morbidity, mortality, disease-free and overall survivals was assessed relative to other clinicopathological factors. Results: Mean age was 67.15 years and 51% was female. Pancreatic adenocarcinoma represents 66.7% of all cases. Pancreaticoduodenectomy was performed in 114 cases (79.2%). Margin status was R0 in 76.9%. Mean BMI was 24.85 Kg/m2 and mean SMI was 35,43 cm2 /m2 . One hundred and eight (74.5%) were sarcopenic, 37 (43.5%) were overweight/ obese and 43 (29.7%) were both (p = 0.041). Sarcopenia was significantly related to histology, sex, BMI and albumin. Overall morbidity and 90-days mortality were 50.7% and 9.1% respectively. The median follow up was 21 months. Overall and disease-free survival rate were 25,44 months and 11,84 months respectively. Sarcopenia was associated to a not statistically significant increased risk of overall morbidity, mortality and shorter disease- free and overall survivals after pancreatic surgery for cancer. Conclusions: Sarcopenia was found in 74.5% of cancer patients underwent pancreatectomy. It is an occult condition in overweight/obese patients but can be identified using CT scans. This condition, as defined by international consensus, is not associated with worse short-term and long-term outcomes after surgery

Liberdade Religiosa E Paz

queremos acrescentar outro direito específico, mas indicar uma condição de vida que inclua em si não apenas o gozo efetivo de todos os direitos fundamentais, mas também viver em uma sociedade decente no que diz respeito à justiça e segurança, um grau satisfatório de desenvolvimento social e econômico, um clima social e político marcado pelo reconhecimento de diferentes identidades, confiança mútua e diálogo em um regime de pluralismo

O DIREITO FUNDADO E O RETORNO DA RAZÃO PRÁTICA NA SOCIEDADE PÓS-MODERNA

Artigo traduzido com autorização do autor pelo Dr. Antonio Alves de Carvalho e Dr. José Roberto Bonome, professores no curso de Direito da Universidade Evangélica de Goiás, pesquisadores e tradutores no NPDU da faculdade de Direito da Unievangelica – Anápolis – Goiás

Acoustic recordings of rough-toothed dolphin (Steno bredanensis) offshore Eastern Sicily (Mediterranean Sea)

Author Posting. © Acoustical Society of America, 2019. This article is posted here by permission of Acoustical Society of America for personal use, not for redistribution. The definitive version was published in Journal of the Acoustical Society of America 146(3), (2019): EL286-EL292, doi:10.1121/1.5126118.ough-toothed dolphin's abundance and distribution is largely unknown worldwide and evaluation of its conservation status in the Mediterranean Sea is necessary. A rough-toothed dolphin was sighted offshore Eastern Sicily (Mediterranean Sea) in July 2017 and acoustic data were acquired in the same area of Watkins, Tyack, Moore, and Notarbartolo di Sciara [(1987). Mar. Mamm. Sci. 3, 78–82]. An automatic detection algorithm was developed to identify the echolocation clicks recorded within both datasets and a recurrent inter-click interval value was identified during the new encounter. Distinctive whistle classes were also identified with similar contour shapes within both datasets.The research has been partially funded by ONR Award (No. N00014-16-1-3017) and National Natural Science Foundation of China (Nos. 41422604 and 41306169). The authors declare that they have no conflict of interest. They wish to thank Professor Gianni Pavan for the software seapro. F.C. wants to thank the President's International Fellowship Initiative (PIFI) of the Chinese Academy of Sciences. F.C. and V.S. contributed equally to this work.2020-03-2

Differentiating Vogt-Koyanagi-Harada syndrome from recurrent optic neuritis: a case report and review of the literature concerning Hispanic patients

Abstract Background First recognized at the beginning of twentieth century and named after three authors who independently described some affected patients, Vogt-Koyanagi-Harada syndrome is a rare multisystemic autoimmune disease targeting melanin-containing tissues of the eye, meninges, inner ear and skin. It predominantly affects Asian people, but also people with darker skin pigmentation such as Native Americans and Hispanics (Mestizos), whose ancestors moved from Asia across the Bering strait to North America and further down to Central and South America. Heterogenous presentation is observed, especially among different ethnic groups. Here we describe the case of an Hispanic South American patient presenting with multiple visual relapses and thus mimicking recurrent optic neuritis; we provide insights into the differential diagnosis and a brief review of the literature concerning the epidemiology of Vogt-Koyanagi-Harada syndrome in Hispanic patients compared with other ethnic groups. Case presentation A 34-year-old Ecuadorian woman presented over years with multiple relapses involving the visual system. She was investigated in both neurologic and ophthalmic clinical settings. Brain Magnetic Resonance Imaging, cerebrospinal fluid examination, Spectral Domain Optical Coherence Tomography and Fluorescein Angiography were performed. She was misdiagnosed first as an optic neuritis pointing to a demyelinating disorder, then as a posterior scleritis. Due to the protean manifestations of Vogt-Koyanagi-Harada syndrome and the incomplete clinical presentation at the beginning, the right diagnosis was made only at a later disease stage using retrospective criteria. Conclusions Hispanic patients often present without extraocular symptoms in early phases of the disease and they have globally lower rates of intertegumentary signs compared to Asian patients. The diagnosis of a multisystemic disease such as Vogt-Koyanagi-Harada syndrome is a challenge involving specialists operating in different medical fields; especially in urban multiethnic populations, rare etiologies of common symptoms have to be taken into account when performing a differential diagnosis

Partition Functions of Non-Abelian Quantum Hall States

Partition functions of edge excitations are obtained for non-Abelian Hall states in the second Landau level, such as the anti-Read-Rezayi state, the Bonderson-Slingerland hierarchy and the Wen non-Abelian fluid, as well as for the non-Abelian spin-singlet state. The derivation is straightforward and unique starting from the non-Abelian conformal field theory data and solving the modular invariance conditions. The partition functions provide a complete account of the excitation spectrum and are used to describe experiments of Coulomb blockade and thermopower.Comment: 42 pages, 3 figures; published version; minor corrections to sect. 4.