Involuntary unemployment and the marginal welfare cost of taxation in Belgium.

Belgium; Cost; Welfare;

Dynamic compressive strength and crushing properties of expanded polystyrene foam for different strain rates and different temperatures

In this study, static and dynamic compression and crushing tests were conducted on expanded polystyrene (EPS) foam for material characterisation at high strain rates. This was done to obtain the stress strain curve for different temperatures and densities. An influence of the strain rate on the experimental data was shown. The resulting curves for modelling were extracted from the experimental data, which were obtained from high speed drop tower tests. The methodology for the processing of the experimental data for use in the finite element (FE) modelling was presented. The foam material model of LSDyna was used to simulate the dynamic compression process. This model is dedicated to modelling crushable foam with optional damping, tension cut-off, and strain rate effects. The adjustment of the material parameters for successful modelling has been reported. This FE model of EPS foam was validated with experimental data using impact on a "kerbstone" support. This model can be applied for simulation of dynamic loads on a bicycle helmet It is useful for designing a reliable bicycle helmet geometry for different types of accidents. (C) 2016 Elsevier Ltd. All rights reserved

Dietary polyphenols targeting arterial stiffness : Interplay of contributing mechanisms and gut microbiome-related metabolism

Publisher Copyright: © 2019 by the authors. Licensee MDPI, Basel, Switzerland.Increased arterial stiffness is a degenerative vascular process, progressing with age that leads to a reduced capability of arteries to expand and contract in response to pressure changes. This progressive degeneration mainly affects the extracellular matrix of elastic arteries and causes loss of vascular elasticity. Recent studies point to significant interference of dietary polyphenols with mechanisms involved in the pathophysiology and progression of arterial stiffness. This review summarizes data from epidemiological and interventional studies on the effect of polyphenols on vascular stiffness as an illustration of current research and addresses possible etiological factors targeted by polyphenols, including pathways of vascular functionality, oxidative status, inflammation, glycation, and autophagy. Effects can either be inflicted directly by the dietary polyphenols or indirectly by metabolites originated from the host or microbial metabolic processes. The composition of the gut microbiome, therefore, determines the resulting metabolome and, as a consequence, the observed activity. On the other hand, polyphenols also influence the intestinal microbial composition, and therefore the metabolites available for interaction with relevant targets. As such, targeting the gut microbiome is another potential treatment option for arterial stiffness.publishersversionPeer reviewe

Impact of impaired fractional flow reserve after coronary interventions on outcomes: a systematic review and meta-analysis

BACKGROUND: FFR is routinely used to guide percutaneous coronary interventions (PCI). Visual assessment of the angiographic result after PCI has limited efficacy. Even when the angiographic result seems satisfactory FFR after a PCI might be useful for identifying patients with a suboptimal interventional result and higher risk for poor clinical outcome who might benefit from additional procedures. The aim of this meta-analysis was to investigate available data of studies that examined clinical outcomes of patients with impaired vs. satisfactory fractional flow reserve (FFR) after percutaneous coronary interventions (PCI). METHODS: This meta-analysis was carried out according to the Cochrane Handbook for Systematic Reviews. The Mantel-Haenszel method using the fixed-effect meta-analysis model was used for combining the results. Studies were identified by searching the literature through mid-January, 2016, using the following search terms: fractional flow reserve, coronary circulation, after, percutaneous coronary intervention, balloon angioplasty, stent implantation, and stenting. Primary endpoint was the rate of major adverse cardiac events (MACE). Secondary endpoints included rates of death, myocardial infarction (MI), repeated revascularisation. RESULTS: Eight relevant studies were found including a total of 1337 patients. Of those, 492 (36.8 %) had an impaired FFR after PCI, and 853 (63.2 %) had a satisfactory FFR after PCI. Odds ratios indicated that a low FFR following PCI was associated with an impaired outcome: major adverse cardiac events (MACE, OR: 4.95, 95 % confidence interval [CI]: 3.39–7.22, p <0.001); death (OR: 3.23, 95 % CI: 1.19–8.76, p = 0.022); myocardial infarction (OR: 13.83, 95 % CI: 4.75–40.24, p <0.0001) and repeated revascularisation (OR: 4.42, 95 % CI: 2.73–7.15, p <0.0001). CONCLUSIONS: Compared to a satisfactory FFR, a persistently low FFR following PCI is associated with a worse clinical outcome. Prospective studies are needed to identify underlying causes, determine an optimal threshold for post-PCI FFR, and clarify whether simple additional procedures can influence the post-PCI FFR and clinical outcome. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12872-016-0355-7) contains supplementary material, which is available to authorized users

Pareto optimality of noncooperative equilibrium in a time dependent multi-period game

status: publishe

Wage indexation and the exchange rate regime: A strategic analysis

The output and inflation effects of various kinds of shocks depend to a large extent oil the degree of wage indexation and on the degree of foreign exchange market intervention. In this paper we focus on the strategic interactions which arise if the degree of wage indexation belongs to the strategy space of a large trade union. The foreign exchange market intervention rule and the indexation parameter are then the outcome of a game between the government and the trade union.status: publishe