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17 research outputs found

Self-administered outpatient parenteral antimicrobial therapy (S-OPAT) for infective endocarditis: A safe and effective model

Prosthetic Valve Candida spp. Endocarditis: New Insights into Long-term Prognosis-The ESCAPE Study

Author: Aaron L.
Abgueguen P.
Accoceberry I.
Acebal J. G.
Alcolea E. C.
Almela M.
Alonso A.
Alonso L. J.
Alvarez
Alvarez M.
Alvarez N.
Amouroux I.
Amparomartinez
Antorrena I.
Aramburu J.
Aramendi J.
Arana J. C. G.
Arguero V. L.
Armero Y.
Arnaiz A.
Arribasleal J. M.
Asensio M. T.
Asensio V.
Azqueta M.
Bailon I. R.
Bano J. R.
Bastides F.
Baston V. R.
Belaustegui M. C.
Bellido C. M.
Bellisco S.
Bereciartua E.
Bermejo J.
Berrazueta J.
Blanco J. R.
Blasco A. C.
Blazquez A.
Bouchara J. -P.
Bougnoux M. E.
Bouza E.
Bravo-Ferrer J. M.
Brechot N.
Brunet M.
Calvo F. E.
Calzada J. L.
Camou F.
Campana Lazaro M.
Carrasco R.
Cartana R.
Castelo L.
Castillo C. A.
Castro B.
Centella T.
Cervera C.
Chandenier J.
Charlier C.
Chirouze C.
Ciezar A. P.
Climent V.
Costas C.
Cruz A. F.
Cuenca J.
Cuende A. M.
Cuerpo G.
Dannaoui E.
De Alarcon A.
De Benito N.
De Castro A.
De Cueto M.
De Egea V.
De La Hera J.
De La Maria C. G.
De La Morena Valenzuela G.
De La Torre Lima J.
De Zarate Z. O.
Del Mar Alonso M.
Del Rio A.
Del Vecchio M. G.
Delahaye F.
Diez J. G.
Duran M. D. C.
Duran R.
Duran R. M.
Echeverria T.
Esteban A. R.
Eworo A.
Falces C.
Farinas M.
Farinas-Alvarez C.
Fekkar A.
Fernandez A. L.
Ferry T.
Fita G.
Fontanet A.
Fourme T.
Fraile L. I.
Fuerte A.
Fuster D.
Gallego P.
Galvez E. H.
Gaminde E.
Garcia E.
Garcia L.
Garcia R. R.
Gatell J. M.
Georgieva R. I.
Goenaga M. A.
Goikoetxea J.
Gomez M. A. M.
Gonzalez J.
Gourriet F.
Gurgui M.
Gutierrez J. M. A.
Habib G.
Haro J. L.
Henry B.
Hermida J. M.
Hernandez J. L.
Hernandez M. K.
Houze S.
Idigoras P.
Iglesias J. M. R.
Iqbal-Mirza S. Z.
Iribarren J. A.
Iruretagoyena J. R.
Izquierdo R. G.
Jose Goiti J.
Lancon J. -P.
Lefort A.
Leoni M. E. G.
Lepe J. A.
Levast M.
Llamas P.
Llinares P.
Loeches B.
Lopez A. M.
Lopez F.
Lopez M. V. G.
Lopez-Soria L.
Lortholary O.
Luis Moya J.
Luque R.
Mainardi J. -L.
Marco F.
Marin M.
Marrero D. G.
Martin-Davila P.
Martinez B. P.
Martinez F. J.
Martinez-Selles M.
Matos J. A. U.
Mayo M. R.
Menarguez M. C.
Menciabajo P.
Menendez J. L.
Merino E.
Mestres C. A.
Million L.
Miro J. M.
Mollar J. C.
Montejo M.
Morales C.
Morales J. R.
Moreno A.
Moreno E. V.
Moreno M.
Munoz P.
Nacle M. B.
Nassar I.
Navas E.
Ninot S.
Noureddine M.
Oliva E.
Orden B.
Oteo J. A.
Ovize A.
Pacho C.
Pajaron M.
Palomo C.
Pare C.
Parra J. A.
Pau J. L.
Pavia P. G.
Perez J. L.
Perez P. M.
Pericas J. M.
Pericas R.
Pinilla B.
Pinto A.
Plazas J.
Pomar J. L.
Pons G.
Prieto A.
Quintana E.
Ramallo V. G.
Ramirez J.
Ramirez U.
Ramos A.
Regueiro B.
Regueiro D. S.
Reus S.
Reviejo C.
Rey E. M.
Rico C. G.
Rincon C.
Rivoisy C.
Roca J. J. H.
Rodriguez A. M.
Rodriguez R.
Rodriguez-Abella H.
Rodriguez-Creixems M.
Rogeaux O.
Romero M.
Rosas G.
Rovira I.
Ruiz S.
Saldana A.
Sanchez E.
Sanchez F. F.
Sanchez-Porto A.
Schaeffer L.
Sepulveda M. A.
Serrano P. E.
Sierra P. T.
Sitges M.
Solero M. M.
Soy D.
Strady C.
Suarez J. F.
Tarabini-Castellani P.
Teira R.
Tellez A.
Tenorio C. H.
Tijeira E.
Torres A. H.
Torrico A. M.
Toubas D.
Tric L.
Uriarte O. G.
Urkola X. K.
Valerio M.
Vallejo L.
Vazquez E. G.
Vega M.
Vena A.
Victoria Boado M.
Vila J.
Voces R.
Wallon M.
Wolff M.
Yarza A. I.
Yazdanpanah Y.
Zarauza J.
Zuazabal J. I.
Publication venue: place:JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
Publication date: 01/01/2018
Field of study

Background. Prosthetic valve endocarditis caused by Candida spp. (PVE-C) is rare and devastating, with international guidelines based on expert recommendations supporting the combination of surgery and subsequent azole treatment. Methods. We retrospectively analyzed PVE-C cases collected in Spain and France between 2001 and 2015, with a focus on management and outcome. Results. Forty-six cases were followed up for a median of 9 months. Twenty-two patients (48%) had a history of endocarditis, 30 cases (65%) were nosocomial or healthcare related, and 9 (20%) patients were intravenous drug users. "Induction" therapy consisted mainly of liposomal amphotericin B (L-amB)-based (n = 21) or echinocandin-based therapy (n = 13). Overall, 19 patients (41%) were operated on. Patients <66 years old and without cardiac failure were more likely to undergo cardiac surgery (adjusted odds ratios [aORs], 6.80 [95% confdence interval [CI], 1.59-29.13] and 10.92 [1.15-104.06], respectively). Surgery was not associated with better survival rates at 6 months. Patients who received L-amB alone had a better 6-month survival rate than those who received an echinocandin alone (aOR, 13.52; 95% CI, 1.03-838.10). "Maintenance" fluconazole therapy, prescribed in 21 patients for a median duration of 13 months (range, 2-84 months), led to minor adverse effects. Conclusion. L-amB induction treatment improves survival in patients with PVE-C. Medical treatment followed by long-term maintenance fluconazole may be the best treatment option for frail patients

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