Experimental demonstration of a novel heterogeneously integrated III-V on Si microlaser

In this work we present the first experimental demonstration of a novel class of heterogeneously integrated III-V-on-silicon microlasers. We first show that by coupling a silicon cavity to a III-V wire, the interaction between the propagating mode in the III-V wire and the cavity mode in the silicon resonator results in high, narrow band reflection back into the III-V waveguide, forming a so-called resonant mirror. By combining two such mirrors and providing optical gain in the III-V wire in between these 2 mirrors, laser operation can be realized. We simulate the reflectivity spectrum of such a resonant mirror using 3D FDTD and discuss the results. We also present experimental results of the very first optically pumped heterogeneously integrated resonant mirror laser. The fabricated device measures 55 mu m by 2 mu m and shows single mode laser emission with a side-mode suppression ratio of 37 dB

AmyPro: a database of proteins with validated amyloidogenic regions

Soluble functional proteins may transform into insoluble amyloid fibrils that deposit in a variety of tissues. Amyloid formation is a hallmark of age-related degenerative disorders. Perhaps surprisingly, amyloid fibrils can also be beneficial and are frequently exploited for diverse functional roles in organisms. Here we introduce AmyPro, an open-access database providing a comprehensive, carefully curated collection of validated amyloid fibril-forming proteins from all kingdoms of life classified into broad functional categories (http://amypro.net). In particular, AmyPro provides the boundaries of experimentally validated amyloidogenic sequence regions, short descriptions of the functional relevance of the proteins and their amyloid state, a list of the experimental techniques applied to study the amyloid state, important structural/functional/variation/mutation data transferred from UniProt, a list of relevant PDB structures categorized according to protein states, database cross-references and literature references. AmyPro greatly improves on similar currently available resources by incorporating both prions and functional amyloids in addition to pathogenic amyloids, and allows users to screen their sequences against the entire collection of validated amyloidogenic sequence fragments. By enabling further elucidation of the sequential determinants of amyloid fibril formation, we hope AmyPro will enhance the development of new methods for the precise prediction of amyloidogenic regions within proteins

Tuning silicon-on-insulator ring resonators with in-plane switching liquid crystals

We show that the resonance wavelength of silicon-on-insulator ring resonators can be tuned when a top cladding of liquid crystal is present. In-plane strip electrodes are used to generate an electric field that reorients the liquid crystal director in the plane parallel to the chip surface. This causes the resonance wavelength to shift toward longer wavelengths. The magnitude of this shift is about 1 nm, which is twice as large as previously reported shifts. The experimental results are verified extensively with our simulation tools, where a calculation of the director orientation is combined with a fully anisotropic mode solver. From this, we get a clear view of the mechanism behind the tuning. (C) 2010 Optical Society of Americ

Mapping mean total annual precipitation in Belgium, by investigating the scale of topographic control at the regional scale

Accurate precipitation maps are essential for ecological, environmental, element cycle and hydrological models that have a spatial output component. It is well known that topography has a major influence on the spatial distribution of precipitation and that increasing topographical complexity is associated with increased spatial heterogeneity in precipitation. This means that when mapping precipitation using classical interpolation techniques (e.g. regression, kriging, spline, inverse distance weighting, etc.), a climate measuring network with higher spatial density is needed in mountainous areas in order to obtain the same level of accuracy as compared to flatter regions. In this study, we present a mean total annual precipitation mapping technique that combines topographical information (i.e. elevation and slope orientation) with average total annual rain gauge data in order to overcome this problem. A unique feature of this paper is the identification of the scale at which topography influences the precipitation pattern as well as the direction of the dominant weather circulation. This method was applied for Belgium and surroundings and shows that the identification of the appropriate scale at which topographical obstacles impact precipitation is crucial in order to obtain reliable mean total annual precipitation maps. The dominant weather circulation is determined at 260°. Hence, this approach allows accurate mapping of mean annual precipitation patterns in regions characterized by rather high topographical complexity using a climate data network with a relatively low density and/or when more advanced precipitation measurement techniques, such as radar, aren't available, for example in the case of historical data