Design guidelines for web readability

Reading is fundamental to interactive-system use, but around 800 million of people might struggle with it due to literacy difficulties. Few websites are designed for high readability, as readability remains an underinvestigated facet of User Experience. Existing readability guidelines have multiple issues: they are too many or too generic, poorly worded, and often lack cognitive grounding. This paper developed a set of 61 readability guidelines in a series of workshops with design and dyslexia experts. A user study with dyslexic and average readers further narrowed the 61-guideline set down to a core set of 12 guidelines - an acceptably small set to keep in mind while designing. The core-set guidelines address reformatting - such as using larger fonts and narrower content columns, or avoiding underlining and italics - and may well aply to the interactive system other than websites. © 2017 Copyright is held by the owner/author(s)

Design, synthesis and biological activity of selective hCAs inhibitors based on 2-(benzylsulfinyl)benzoic acid scaffold

A large library of derivatives based on the scaffold of 2-(benzylsulfinyl)benzoic acid were synthesised and tested as atypical inhibitors against four different isoforms of human carbonic anhydrase (hCA I, II, IX and XII, EC 4.2.1.1). The exploration of the chemical space around the main functional groups led to the discovery of selective hCA IX inhibitors in the micromolar/nanomolar range, thus establishing robust structure-activity relationships within this versatile scaffold. HPLC separation of some selected chiral compounds and biological evaluation of the corresponding enantiomers was performed along with molecular modelling studies on the most active derivatives

Dust remobilization in fusion plasmas under steady state conditions

The first combined experimental and theoretical studies of dust remobilization by plasma forces are reported. The main theoretical aspects of remobilization in fusion devices under steady state conditions are analyzed. In particular, the dominant role of adhesive forces is highlighted and generic remobilization conditions - direct lift-up, sliding, rolling - are formulated. A novel experimental technique is proposed, based on controlled adhesion of dust grains on tungsten samples combined with detailed mapping of the dust deposition profile prior and post plasma exposure. Proof-of-principle experiments in the TEXTOR tokamak and the EXTRAP-T2R reversed-field pinch are presented. The versatile environment of the linear device Pilot-PSI allowed for experiments with different magnetic field topologies and varying plasma conditions that were complemented with camera observations.Comment: 16 pages, 11 figures, 3 table

Photometric metallicity for 694233 Galactic giant stars from Gaia DR3 synthetic Stromgren photometry. Metallicity distribution functions of halo sub-structures

We use the calibrations by Calamida et al. and by Hilker et al., and the standardised synthetic photometry in the v, b, and y Stromgren passbands from Gaia DR3 BP/RP spectra, to obtain photometric metallicities for a selected sample of 694233 old Galactic giant stars having |b|>20.0 and parallax uncertainties lower than 10%. The zero point of both sets of photometric metallicities has been shifted to to ensure optimal match with the spectroscopic [Fe/H] values for 44785 stars in common with APOGEE DR17, focusing on the metallicity range where they provide the highest accuracy. The metallicities derived in this way from the Calamida et al. calibration display a typical accuracy of ~0.1 dex and 1 sigma precision ~0.2 dex in the range -2.2 <=[Fe/H]<= -0.4, while they show a systematic trend with [Fe/H] at higher metallicity, beyond the applicability range of the relation. Those derived from the Hilker et al. calibration display, in general, worse precision, and lower accuracy in the metal-poor regime, but have a median accuracy < 0.05 dex for [Fe/H]>= -0.8. These results are confirmed and, consequently, the metallicities validated, by comparison with large sets of spectroscopic metallicities from various surveys. The newly obtained metallicities are used to derive metallicity distributions for several previously identified sub-structures in the Galactic halo with an unprecedented number of stars. The catalogue including both sets of metallicities and the associated uncertainties is made publicly available.Comment: Accepted for publication by Astronomy & Astrophysics. Latex. 20 pages, 21 color figures. The catalogue will be publicly available at CDS. In the meanwhile it is available upon request to the first autho

Metal-poor stars with disc-like orbits. Traces of the Galactic Disc at very early epochs?

We use photometric metallicity estimates for about 700000 stars in the surroundings of the Sun, with very accurate distances and 3-D motions measures from Gaia DR3, to explore the properties of the metal-poor (-2.0<[Fe/H]<= -1.5; MP) and very metal-poor ([Fe/H]<= -2.0; VMP) stars with disc kinematics in the sample. We confirm the presence of a significant fraction of MP and VMP stars with disc-like orbits and that prograde orbits are prevalent among them, with prograde to retrograde ratio P/R ~3. We highlight for the first time a statistically significant difference in the distribution of the Z-component of the angular momentum (L_Z) and orbital eccentricity between prograde and retrograde disc-like MP stars. The same kind of difference is found also in the VMP subsample, albeit at a much lower level of statistical significance, likely due to the small sample size. We show that prograde disc-like MP and VMP stars display an additional component of the |L_Z| distribution with respect to their retrograde counterpart. This component is at higher |L_Z| with respect to the main peak of the distribution, possibly hinting at the presence of a pristine prograde disc in the Milky Way. This hypothesis is supported by the results of the analysis of a large sub-sample dominated by stars born in-situ. Also in this case the prevalence of prograde stars is clearly detected at [Fe/H]<= -1.5 and their |L_Z| distribution is more skewed toward high |L_Z| values than their retrograde counterpart. This suggests that the seed of what will eventually evolve into the main disc components of the Milky Way may have been already in place in the earliest phases of the Galaxy assembly.Comment: Accepted by A&A. Latex, 7 pages, 6 colour figure

Adhesive force distributions for tungsten dust deposited on bulk tungsten and beryllium-coated tungsten surfaces

Comprehensive measurements of the adhesive force for tungsten dust adhered to tungsten surfaces have been performed with the electrostatic detachment method. Monodisperse spherical dust has been deposited with gas dynamics techniques or with gravity mimicking adhesion as it naturally occurs in tokamaks. The adhesive force is confirmed to follow the log-normal distribution and empirical correlations are proposed for the size-dependence of its mean and standard deviation. Systematic differences are observed between the two deposition methods and attributed to plastic deformation during sticking impacts. The presence of thin beryllium coatings on tungsten surfaces is demonstrated to barely affect adhesion

The MODEST questions: challenges and future directions in stellar cluster research

We present a review of some of the current major challenges in stellar cluster research, including young clusters, globular clusters, and galactic nuclei. Topics considered include: primordial mass segregation and runaway mergers, expulsion of gas from clusters, the production of stellar exotica seen in some clusters (eg blue stragglers and extreme horizontal--branch stars), binary populations within clusters, the black--hole population within stellar clusters, the final parsec problem, stellar dynamics around a massive black hole, and stellar collisions. The Modest Questions posed here are the outcome of discussions which took place at the Modest-6A workshop held in Lund, Sweden, in December, 2005. Modest-6A was organised as part of the activities of the Modest Collaboration (see www.manybody.org for further details

Excessive daytime sleepiness and hepatic encephalopathy: It is worth asking

The relationship between hepatic encephalopathy (HE) and the sleep-wake disturbances exhibited by patients with cirrhosis remains debated. The aim of this study was to examine the usefulness of sleep-wake interview within the context of HE assessment. One-hundred-and-six cirrhotic patients were asked three yes/no questions investigating the presence of difficulty falling asleep, night awakenings and daytime sleepiness. All underwent formal HE assessment, quantitative electroencephalography and standardised psychometry. Fifty-eight were monitored for 8 +/- 6 months in relation to the occurrence of HE. Patients complaining of daytime sleepiness (n = 75, 71 %) had slower EEGs than those who did not report it (relative alpha power: 37 +/- 19 vs. 48 +/- 17 %, p &lt; 0.05). In addition, daytime sleepiness was associated with the presence of portal-systemic shunt (79 vs. 57 %, p &lt; 0.05) and HE history (72 vs. 45 %, p &lt; 0.05). Finally, the absence of excessive daytime sleepiness had a Negative Predictive Value of 92 % (64-100) in relation to the development of HE during the follow-up period. These data support the appropriateness of adding a yes/no question on the presence of excessive daytime sleepiness to routine assessment of patients with cirrhosis, to help identify those who do not need further, formal HE screening

Diffusion bonding effects on the adhesion of tungsten dust on tungsten surfaces

Abstract High temperature excursions have the potential to strongly enhance the room temperature adhesion of tokamak dust. Planar tungsten substrates containing adhered nearly monodisperse spherical tungsten dust have been exposed to linear plasmas and vacuum furnaces. Prolonged thermal treatments of varying peak temperature and constant duration were followed by room temperature adhesion measurements with the electrostatic detachment method. Adhesive forces have been observed to strongly depend on the thermal pre-history, greatly increasing above a threshold temperature. Adhesive forces have been measured up to an order of magnitude larger than those of untreated samples. This enhancement has been attributed to atomic diffusion that slowly eliminates the omnipresent nanometer-scale surface roughness, ultimately switching the dominant interaction from long-range weak van der Waals forces to short-range strong metallic bonding