25,242 research outputs found
Erythrocyte as a link between basic and clinical research
© 2011 – IOS Press and the authorsWe review the major hemorheological experimental studies that show the erythrocyte aggregation as a link between basic and clinical research. The results of the clinical cross-sectional and longitudinal studies presented here will highlight the possible association between erythrocyte aggregation and plasma fibrinogen. Basic studies conducted in vitro are also mentioned as for its relevance in answering questions raised in clinical settings, as well as and in understanding the underlying influent factors in the erythrocyte tendency to aggregate and disaggregate.This work was supported by
“Fundação para a Ciência e Tecnologia
How good are MatLab, Octave and Scilab for Computational Modelling?
In this article we test the accuracy of three platforms used in computational
modelling: MatLab, Octave and Scilab, running on i386 architecture and three
operating systems (Windows, Ubuntu and Mac OS). We submitted them to numerical
tests using standard data sets and using the functions provided by each
platform. A Monte Carlo study was conducted in some of the datasets in order to
verify the stability of the results with respect to small departures from the
original input. We propose a set of operations which include the computation of
matrix determinants and eigenvalues, whose results are known. We also used data
provided by NIST (National Institute of Standards and Technology), a protocol
which includes the computation of basic univariate statistics (mean, standard
deviation and first-lag correlation), linear regression and extremes of
probability distributions. The assessment was made comparing the results
computed by the platforms with certified values, that is, known results,
computing the number of correct significant digits.Comment: Accepted for publication in the Computational and Applied Mathematics
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Physical properties of the Schur complement of local covariance matrices
General properties of global covariance matrices representing bipartite
Gaussian states can be decomposed into properties of local covariance matrices
and their Schur complements. We demonstrate that given a bipartite Gaussian
state described by a covariance matrix \textbf{V}, the
Schur complement of a local covariance submatrix of it can be
interpreted as a new covariance matrix representing a Gaussian operator of
party 1 conditioned to local parity measurements on party 2. The connection
with a partial parity measurement over a bipartite quantum state and the
determination of the reduced Wigner function is given and an operational
process of parity measurement is developed. Generalization of this procedure to
a -partite Gaussian state is given and it is demonstrated that the
system state conditioned to a partial parity projection is given by a
covariance matrix such as its block elements are Schur complements
of special local matrices.Comment: 10 pages. Replaced with final published versio
Uniform approximation for the overlap caustic of a quantum state with its translations
The semiclassical Wigner function for a Bohr-quantized energy eigenstate is
known to have a caustic along the corresponding classical closed phase space
curve in the case of a single degree of freedom. Its Fourier transform, the
semiclassical chord function, also has a caustic along the conjugate curve
defined as the locus of diameters, i.e. the maximal chords of the original
curve. If the latter is convex, so is its conjugate, resulting in a simple fold
caustic. The uniform approximation through this caustic, that is here derived,
describes the transition undergone by the overlap of the state with its
translation, from an oscillatory regime for small chords, to evanescent
overlaps, rising to a maximum near the caustic. The diameter-caustic for the
Wigner function is also treated.Comment: 14 pages, 9 figure
Evidence that the degree of band 3 phosphorylation modulates human erythrocytes nitric oxide efflux – in vitro model of hyperfibrinogenemia
© 2011 – IOS Press and the authors. All rights reservedRecent evidence has shown that plasma fibrinogen, a major cardiovascular risk factor, interacts with the erythrocyte membrane and acts to influence blood flow via erythrocyte nitric oxide (NO) modulation. In the present pioneer in-vitro study, whole blood samples were harvested from healthy subjects and aliquots were incubated in the absence (control aliquots) and presence of fibrinogen at different degrees of band 3 phosphorylation, and the levels of NO, nitrite, nitrate and S-nitroglutathione (GSNO) were determined.
Hyperfibrinogenemia interferes with erythrocyte NO mobilization without changing its efflux in a way that seems to be dependent of the degree of band 3 phosphorylation. In presence of higher fibrinogen concentrations the NO efflux is reinforced when band 3 is phosphorylated (p < 0.001). Higher levels of nitrite, nitrate and GSNO were documented (p < 0.05). However, the mechanisms by which fibrinogen signalling modulates erythrocyte function remain to be clarified and are currently under study. These conditions may be considered an approach to be followed in blood storage for transfusions.This study was supported by grants from the FCT - Fundação para a Ciência e a Tecnologia (project reference PTDC/SAU-OSM/73449/2006
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