Diseño de una propuesta de aula para la enseñanza del concepto de límite de una función aplicando el ambiente geométrico dinámico geogebra

La enseñanza del concepto de límite es fundamental en los estudiantes de educación media, su aprendizaje es esencial para el análisis matemático, rama de la matemática que es prioritaria en las carreras de ingeniería y administración, en las diferentes universidades colombianas. Este trabajo muestra el diseño de una propuesta de aula direccionada a la enseñanza de límite de funciones en un punto, a través de actividades guiadas y haciendo uso de las Tecnologías de la Información y Comunicación, con el propósito de obtener un aprendizaje significativo y duradero del mismo.Abstract: The teaching of the limit concept is fundamental for the middle level students; its learning is essential for mathematical analysis, branch of mathematics which is priority in the engineering and management careers the different colombian universities. This works shows the design of a classroom proposal directed to teaching limit of functions at a point through guided activities and by using the information and communication technologies with the porpose of getting a meaningful and lasting learning of itsel

Immigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native Patients

BackgroundPrevious studies comparing immigrant ethnic groups and native patients with IBD have yielded clinical and phenotypic differences. To date, no study has focused on the immigrant IBD population in Spain. MethodsProspective, observational, multicenter study comparing cohorts of IBD patients from ENEIDA-registry who were born outside Spain with a cohort of native patients. ResultsWe included 13,524 patients (1,864 immigrant and 11,660 native). The immigrants were younger (45 +/- 12 vs. 54 +/- 16 years, p < 0.001), had been diagnosed younger (31 +/- 12 vs. 36 +/- 15 years, p < 0.001), and had a shorter disease duration (14 +/- 7 vs. 18 +/- 8 years, p < 0.001) than native patients. Family history of IBD (9 vs. 14%, p < 0.001) and smoking (30 vs. 40%, p < 0.001) were more frequent among native patients. The most prevalent ethnic groups among immigrants were Caucasian (41.5%), followed by Latin American (30.8%), Arab (18.3%), and Asian (6.7%). Extraintestinal manifestations, mainly musculoskeletal affections, were more frequent in immigrants (19 vs. 11%, p < 0.001). Use of biologics, mainly anti-TNF, was greater in immigrants (36 vs. 29%, p < 0.001). The risk of having extraintestinal manifestations [OR: 2.23 (1.92-2.58, p < 0.001)] and using biologics [OR: 1.13 (1.0-1.26, p = 0.042)] was independently associated with immigrant status in the multivariate analyses. ConclusionsCompared with native-born patients, first-generation-immigrant IBD patients in Spain were younger at disease onset and showed an increased risk of having extraintestinal manifestations and using biologics. Our study suggests a featured phenotype of immigrant IBD patients in Spain, and constitutes a new landmark in the epidemiological characterization of immigrant IBD populations in Southern Europe