4 research outputs found
Synthesis of Stable Multifunctional Perfluorocarbon Nanoemulsions for Cancer Therapy and Imaging
Nanotechnology
provides a promising platform for drug-delivery
in medicine. Nanostructured materials can be designed with desired
superparamagnetic or fluorescent properties in conjunction with biochemically
functionalized moieties (i.e., antibodies, peptides, and small molecules)
to actively bind to target sites. These multifunctional properties
make them suitable agents for multimodal imaging, diagnosis, and therapy.
Perfluorohexane nanoemulsions (PFH-NEs) are novel drug-delivery vehicles
and contrast agents for ultrasound and photoacoustic imaging of cancer <i>in vivo</i>, offering higher spatial resolution and deeper penetration
of tissue when compared to conventional optical techniques. Compared
to other theranostic agents, our PFH-NEs are one of the smallest of
their kind (<100 nm), exhibit
minimal aggregation, long-term stability at physiological conditions,
and provide a noninvasive cancer imaging and therapy alternative for
patients. Here, we show, using high-resolution imaging and correlative
techniques, that our PFH-NEs, when in tandem with silica-coated gold
nanoparticles (scAuNPs), can be used as a drug-loaded therapeutic
via endocytosis and as a multimodal imaging agent for photoacoustic,
ultrasound, and fluorescence imaging of tumor growth
Synthesis of Stable Multifunctional Perfluorocarbon Nanoemulsions for Cancer Therapy and Imaging
Nanotechnology
provides a promising platform for drug-delivery
in medicine. Nanostructured materials can be designed with desired
superparamagnetic or fluorescent properties in conjunction with biochemically
functionalized moieties (i.e., antibodies, peptides, and small molecules)
to actively bind to target sites. These multifunctional properties
make them suitable agents for multimodal imaging, diagnosis, and therapy.
Perfluorohexane nanoemulsions (PFH-NEs) are novel drug-delivery vehicles
and contrast agents for ultrasound and photoacoustic imaging of cancer <i>in vivo</i>, offering higher spatial resolution and deeper penetration
of tissue when compared to conventional optical techniques. Compared
to other theranostic agents, our PFH-NEs are one of the smallest of
their kind (<100 nm), exhibit
minimal aggregation, long-term stability at physiological conditions,
and provide a noninvasive cancer imaging and therapy alternative for
patients. Here, we show, using high-resolution imaging and correlative
techniques, that our PFH-NEs, when in tandem with silica-coated gold
nanoparticles (scAuNPs), can be used as a drug-loaded therapeutic
via endocytosis and as a multimodal imaging agent for photoacoustic,
ultrasound, and fluorescence imaging of tumor growth