A New Genus of Miniaturized and Pug-Nosed Gecko from South America (Sphaerodactylidae: Gekkota)

Sphaerodactyl geckos comprise five genera distributed across Central and South America and the Caribbean. We estimated phylogenetic relationships among sphaerodactyl genera using both separate and combined analyses of seven nuclear genes. Relationships among genera were incongruent at different loci and phylogenies were characterized by short, in some cases zero-length, internal branches and poor phylogenetic support at most nodes. We recovered a polyphyletic Coleodactylus, with Coleodactylus amazonicus being deeply divergent from the remaining Coleodactylus species sampled. The C. amazonicus lineage possessed unique codon deletions in the genes PTPN12 and RBMX while the remaining Coleodactylus species had unique codon deletions in RAG1. Topology tests could not reject a monophyletic Coleodactylus, but we show that short internal branch lengths decreased the accuracy of topology tests because there were not enough data along these short branches to support one phylogenetic hypothesis over another. Morphological data corroborated results of the molecular phylogeny, with Coleodactylus exhibiting substantial morphological heterogeneity. We identified a suite of unique craniofacial features that differentiate C. amazonicus not only from other Coleodactylus species, but also from all other geckos. We describe this novel sphaerodactyl lineage as a new genus, Chatogekko gen. nov. We present a detailed osteology of Chatogekko, characterizing osteological correlates of miniaturization that provide a framework for future studies in sphaerodactyl systematics and biology

Intermediate progenitors support migration of neural stem cells into dentate gyrus outer neurogenic niches.

The hippocampal dentate gyrus (DG) is a unique brain region maintaining neural stem cells (NCSs) and neurogenesis into adulthood. We used multiphoton imaging to visualize genetically defined progenitor subpopulations in live slices across key stages of mouse DG development, testing decades old static models of DG formation with molecular identification, genetic-lineage tracing, and mutant analyses. We found novel progenitor migrations, timings, dynamic cell-cell interactions, signaling activities, and routes underlie mosaic DG formation. Intermediate progenitors (IPs, Tbr2+) pioneered migrations, supporting and guiding later emigrating NSCs (Sox9+) through multiple transient zones prior to converging at the nascent outer adult niche in a dynamic settling process, generating all prenatal and postnatal granule neurons in defined spatiotemporal order. IPs (Dll1+) extensively targeted contacts to mitotic NSCs (Notch active), revealing a substrate for cell-cell contact support during migrations, a developmental feature maintained in adults. Mouse DG formation shares conserved features of human neocortical expansion

BRCA1-BARD1: the importance of being in shape

The breast cancer type-1 susceptibility protein (BRCA1) contributes to genome integrity through homologous recombinational DNA repair and by protecting stalled replication forks from nucleolytic degradation. We recently discovered that fork protection requires a conformational change of BRCA1 unimportant to homologous recombination repair, indicating separate roles for BRCA1 in these pathways

Lesiones esqueléticas asociadas al síndrome de Papillon-Lefèvre

Se presentan dos casos de Síndrome de Papillon-Lefèvre que se asocian a osteolisis espontánea de los metatarsianos y las falanges de los dedos de los pies. Esta asociación no había sido descrita con anterioridad.Two case s of Papillon-Lefèvre syndrome associated with spontaneous osteolysis of the phalanges and metatarsals of the toe s are presented. This association has not been previously reported

M2LADS: A System for Generating MultiModal Learning Analytics Dashboards

In this article, we present a Web-based System called M2LADS, which supports the integration and visualization of multimodal data recorded in learning sessions in a MOOC in the form of Web-based Dashboards. Based on the edBB platform, the multimodal data gathered contains biometric and behavioral signals including electroencephalogram data to measure learners' cognitive attention, heart rate for affective measures, visual attention from the video recordings. Additionally, learners' static background data and their learning performance measures are tracked using LOGCE and MOOC tracking logs respectively, and both are included in the Web-based System. M2LADS provides opportunities to capture learners' holistic experience during their interactions with the MOOC, which can in turn be used to improve their learning outcomes through feedback visualizations and interventions, as well as to enhance learning analytics models and improve the open content of the MOOC

Luxación traumática bilateral de cadera

Se presenta un caso de luxación bilateral simultánea de caderas, una anterior y otra posterior, asociada a fractura del acetábulo derecho, fractura de la diáfisis femoral derecha y una subluxación del raquis cervical.A case of simultaneous bilateral anterior and posterior dislocation of the hip joints associated with a fracture of the right acetabulum and right femoral shaft, and a subluxation of the cervical spine, is reported

Nanoparticle-and liposome-carried drugs: New strategies for active targeting and drug delivery across blood-brain barrier

The blood-brain barrier (BBB), the unusual microvascular endothelial interface between the central nervous system (CNS) and the circulatory system, is a major hindrance to drug delivery in the brain parenchyma. Besides the absence of fenestrations and the abundance of tight junctions, ATP-binding cassette (ABC) transporters critically reduce drug entry within the CNS, as they carry many drugs back into the bloodstream. Nanoparticle-and liposome-carried drugs, because of their increased cellular uptake and reduced efflux through ABC transporters, have been developed in recent times to circumvent the low drug permeability of the BBB. This review discusses the role of ABC transporters in controlling drug penetration into the brain parenchyma, the rationale for using nanoparticle-and liposome-based strategies to increase drug delivery across the BBB and new therapeutic strategies for using nanoparticle-and liposome-carried drugs in different conditions, ranging from CNS tumors and neurodegenerative diseases to viral infections and epilepsy. © 2013 Bentham Science Publishers

Breit Equation with Form Factors in the Hydrogen Atom

The Breit equation with two electromagnetic form-factors is studied to obtain a potential with finite size corrections. This potential with proton structure effects includes apart from the standard Coulomb term, the Darwin term, retarded potentials, spin-spin and spin-orbit interactions corresponding to the fine and hyperfine structures in hydrogen atom. Analytical expressions for the hyperfine potential with form factors and the subsequent energy levels including the proton structure corrections are given using the dipole form of the form factors. Numerical results are presented for the finite size corrections in the 1S and 2S hyperfine splittings in the hydrogen atom, the Sternheim observable $D_{21}$ and the 2S and 2P hyperfine splittings in muonic hydrogen. Finally, a comparison with some other existing methods in literature is presented.Comment: 24 pages, Latex, extended version, title change