Repercusiones metabólicas de los ácidos grasos trans de la dieta sobre el desarrollo y la composición tisular en la rata / Elvira Larqué Daza ; directores Salvador Zamora Navarro, Angel Gil Hernández.

Tesis-Universidad de Murcia.MEDICINA ESPINARDO. DEPOSITO. MU-Tesis 605.Consulte la tesis en: BCA. GENERAL. ARCHIVO UNIVERSITARIO. T.M.-1885

Buscando alternativas a los suplementos clásicos de DHA para embarazadas

La suplementación con ácido docosahexaenoico {DHA) durante el embarazo ha sido recomendada por diversos organismos debido a su importante papel en el desarrollo cognitivo y visual, sobre todo durante la infancia. Actualmente, existen diversas fuentes grasas que pueden ser utilizadas para la suplementación con DHA durante la gestación y que difieren en la estructura lipídica en la que se encuentra el DHA: fosfolípido {FL) o triglicérido (TG), entre otras. El objetivo principal de esta tesis doctoral fue estudiar si la administración de FL ricos en DHA durante la gestación es una mejor fuente, con mayor biodisponibilidad para la placenta e incorporación en el feto, especialmente en el cerebro fetal, que la administración clásica de DHA en forma de TG. Para ello, llevamos a cabo un experimento in vivo en ratas gestantes

Docosahexaenoic acid supplementation during pregnancy as phospholipids or triglycerides produces different placental uptake but similar fetal brain accretion in neonatal piglets

The great variety of n-3 long chain polyunsaturated fatty acid sources raises the question of the most adequate for using as a docosahexaenoic acid (DHA) supplement during pregnancy. Placental and fetal availability of different DHA sources remains unclear. We investigated DHA availability in maternal lipoproteins, placenta and fetal tissues in pregnant sows fed DHA as phospholipid (PL) or triglyceride (TG) to identify the best DHA source during this period. Pregnant Iberian sows were fed with diets containing 0.8% DHA of total fatty acids as PL from egg yolk or TG from algae oil during the last third of gestation (40 days). Maternal tissues, placentas and fetal tissues were obtained at delivery and DHA quantified by gas-chromatography. MFSD2a carrier expression was analysed in both placenta and fetal brain by western blotting. Sows fed DHA-PL diet showed higher DHA incorporation in plasma LDL but not in plasma total lipids. No differences were found in DHA content between groups in maternal liver, adipose tissue or brain. Placental tissue incorporated more DHA in both total lipids and PL fraction in sows fed DHA-PL. However, this did not lead to an enhanced DHA accretion either in fetal plasma, fetal liver or fetal brain. MFSD2a expression was similar between both experimental groups. Maternal DHA supplementation during pregnancy in sow either as PL or TG produces similar DHA accretion in fetal tissues but not in placenta. Both fat sources are equally available for fetal brain

Child Head Circumference and Placental MFSD2a Expression Are Associated to the Level of MFSD2a in Maternal Blood During Pregnancy

©. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by /4.0/ This document is the Published Manuscript version of a Published Work that appeared in final form in [Frontiers in Endocrinology]. To access the final edited and published work see[10.3389/fendo.2020.00038

The Evolving Microbiome from Pregnancy to Early Infancy: A Comprehensive Review

©. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by /4.0/ This document is the Published Manuscript version of a Published Work that appeared in final form in [Nutrients]. To access the final edited and published work see [10.3390/nu12010133