3,812 research outputs found

    The Dentist and the Missions

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    Roadway System Assessment Using Bluetooth-Based Automatic Vehicle Identification Travel Time Data

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    This monograph is an exposition of several practice-ready methodologies for automatic vehicle identification (AVI) data collection systems. This includes considerations in the physical setup of the collection system as well as the interpretation of the data. An extended discussion is provided, with examples, demonstrating data techniques for converting the raw data into more concise metrics and views. Examples of statistical before-after tests are also provided. A series of case studies were presented that focus on various real-world applications, including the impact of winter weather on freeway operations, the economic benefit of traffic signal retiming, and the estimation of origin-destination matrices from travel time data. The technology used in this report is Bluetooth MAC address matching, but the concepts are extendible to other AVI data sources

    Encapsulation of conducting polymers within zeolites

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    A homoleptic phosphine adduct of Tl(I)

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    A homoleptic phosphine adduct of thallium(I) supported by a tris(phosphino)borate ligand has been isolated and structurally characterized

    Tuning magnetic frustration on the diamond lattice of the A-site magnetic spinels CoAl2x_{2-x}Gax_xO4_4: Lattice expansion and site disorder

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    The spinels CoB2_2O4_4 with magnetic Co2+^{2+} ions on the diamond lattice A site can be frustrated because of competing near-neighbor (J1J_1) and next-near neighbor (J2J_2) interactions. Here we describe attempts to tune the relative strengths of these interactions by substitution on the non-magnetic B-site. The system we employ is CoAl2x_{2-x}Gax_xO4_4, where Al is systematically replaced by the larger Ga, ostensibly on the B site. As expected, Ga substitution expands the lattice, resulting in Co atoms on the A-site being pushed further from one other and thereby weakening magnetic interactions. In addition, Ga distributes between the B and the A site in a concentration dependent manner displacing an increasing amount of Co from the A site with increasing xx. This increased inversion, which is confirmed by neutron diffraction studies carried out at room temperature, affects magnetic ordering very significantly, and changes the nature of the ground state. Modeling of the magnetic coupling illustrates the complexity that arises from the cation site disorder.Comment: 9 pages, 10 figure

    Analysis of Peer Intersection Data for Arterial Traffic Signal Coordination Decisions

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    This is the author-accepted manuscript version of Day, C.M., T.M. Brennan, H. Premachandra, J.R. Sturdevant, and D.M. Bullock, “Analysis of Peer Data on Intersections for Decisions About Coordination of Arterial Traffic Signal,”Transportation Research Record: Journal of the Transportation Research Board, No. 2259, Transportation Research Board of the National Academies, Washington, D.C., pp. 23–36, 2011, copyright National Academy of Sciences.http://dx.doi.org/10.3141/2259-03 Its corresponding poster can be found here:http://docs.lib.purdue.edu/atspmw/2016/Posters/3

    Homology blocks of Plasmodium falciparum var genes and clinically distinct forms of severe malaria in a local population

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    Abstract Background The primary target of the human immune response to the malaria parasite Plasmodium falciparum, P. falciparum erythrocyte membrane protein 1 (PfEMP1), is encoded by the members of the hyper-diverse var gene family. The parasite exhibits antigenic variation via mutually exclusive expression (switching) of the ~60 var genes within its genome. It is thought that different variants exhibit different host endothelial binding preferences that in turn result in different manifestations of disease. Results Var sequences comprise ancient sequence fragments, termed homology blocks (HBs), that recombine at exceedingly high rates. We use HBs to define distinct var types within a local population. We then reanalyze a dataset that contains clinical and var expression data to investigate whether the HBs allow for a description of sequence diversity corresponding to biological function, such that it improves our ability to predict disease phenotype from parasite genetics. We find that even a generic set of HBs, which are defined for a small number of non-local parasites: capture the majority of local sequence diversity; improve our ability to predict disease severity from parasite genetics; and reveal a previously hypothesized yet previously unobserved parasite genetic basis for two forms of severe disease. We find that the expression rates of some HBs correlate more strongly with severe disease phenotypes than the expression rates of classic var DBLα tag types, and principal components of HB expression rate profiles further improve genotype-phenotype models. More specifically, within the large Kenyan dataset that is the focus of this study, we observe that HB expression differs significantly for severe versus mild disease, and for rosetting versus impaired consciousness associated severe disease. The analysis of a second much smaller dataset from Mali suggests that these HB-phenotype associations are consistent across geographically distant populations, since we find evidence suggesting that the same HB-phenotype associations characterize this population as well. Conclusions The distinction between rosetting versus impaired consciousness associated var genes has not been described previously, and it could have important implications for monitoring, intervention and diagnosis. Moreover, our results have the potential to illuminate the molecular mechanisms underlying the complex spectrum of severe disease phenotypes associated with malaria—an important objective given that only about 1% of P. falciparum infections result in severe disease.http://deepblue.lib.umich.edu/bitstream/2027.42/112650/1/12866_2013_Article_2116.pd
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