Utilization of parallel processing in solving the inviscid form of the average-passage equation system for multistage turbomachinery

A procedure is outlined which utilizes parallel processing to solve the inviscid form of the average-passage equation system for multistage turbomachinery along with a description of its implementation in a FORTRAN computer code, MSTAGE. A scheme to reduce the central memory requirements of the program is also detailed. Both the multitasking and I/O routines referred to are specific to the Cray X-MP line of computers and its associated SSD (Solid-State Disk). Results are presented for a simulation of a two-stage rocket engine fuel pump turbine

The dynamics of innovation and social capital in social enterprises: a relational sense-making perspective

We develop a relational sense-making framework in order to understand the ways in which knowledge and information, when transferred across social networks, enable or inhibit the innovation process and its sustainability within social enterprises. Our model comprises four main elements: (i) Social capital, (ii) the Innovation, (iii) the Process, and (iv) Adoption and ongoing support (SIPA). Collective understanding through sense-making and sense-giving is fundamental to the successful management and sustainability of innovation projects. The social capital which emerges and develops may incorporate formal and/or informal group(s) linked by particular interests, common goals and/or shared agenda(s). Broadly speaking, the innovation may be directed towards either a problem or an opportunity for the collective. The ‘black box’ process through which different views and interests are presented, interpreted and collective sense-making occurs in the further development and uptake of innovation is by its nature: multifaceted, complex and non-linear. The temporal fragility of certain innovations necessitates ongoing support and acceptance in order to achieve longer-term sustainability. The iterative relations between these elements of social capital, innovation, process and adoption occur within a social, political and economic context in which sense-making and sense-giving of individuals and groups often compete. A key objective of our research is, therefore, to tease out the extent to which and the ways in which social relationships and networks, innovation intentions and technology development are influenced by social capital dynamics within organizations, social enterprises in particular

Auxiliary field formalism for dilute fermionic atom gases with tunable interactions

We develop the auxiliary field formalism corresponding to a dilute system of spin-1/2 fermions. This theory represents the Fermi counterpart of the BEC theory developed recently by F. Cooper et al. [Phys. Rev. Lett. 105, 240402 (2010)] to describe a dilute gas of Bose particles. Assuming tunable interactions, this formalism is appropriate for the study of the crossover from the regime of Bardeen-Cooper-Schriffer (BCS) pairing to the regime of Bose-Einstein condensation (BEC) in ultracold fermionic atom gases. We show that when applied to the Fermi case at zero temperature, the leading-order auxiliary field (LOAF) approximation gives the same equations as those obtained in the standard BCS variational picture. At finite temperature, LOAF leads to the theory discussed by by Sa de Melo, Randeria, and Engelbrecht [Phys. Rev. Lett. 71, 3202(1993); Phys. Rev. B 55, 15153(1997)]. As such, LOAF provides a unified framework to study the interacting Fermi gas. The mean-field results discussed here can be systematically improved upon by calculating the one-particle irreducible (1-PI) action corrections, order by order.Comment: 12 pages, 5 figure

On the forward cone quantization of the Dirac field in "longitudinal boost-invariant" coordinates with cylindrical symmetry

We obtain a complete set of free-field solutions of the Dirac equation in a (longitudinal) boost-invariant geometry with azimuthal symmetry and use these solutions to perform the canonical quantization of a free Dirac field of mass $M$. This coordinate system which uses the 1+1 dimensional fluid rapidity $\eta = 1/2 \ln [(t-z)/(t+z)]$ and the fluid proper time $\tau = (t^2-z^2)^{1/2}$ is relevant for understanding particle production of quarks and antiquarks following an ultrarelativistic collision of heavy ions, as it incorporates the (approximate) longitudinal "boost invariance" of the distribution of outgoing particles. We compare two approaches to solving the Dirac equation in curvilinear coordinates, one directly using Vierbeins, and one using a "diagonal" Vierbein representation

Factors associated with dog ownership and contact with dogs in a UK community

BACKGROUND: Dogs are popular pets in many countries. Identifying differences between those who own dogs or have contact with dogs, and those who do not, is useful to those interested in the human-animal bond, human health and for provision of veterinary services. This census-based, epidemiological study aimed to investigate factors associated with dog ownership and contact with dogs, in a semi-rural community of 1278 households in Cheshire, UK. RESULTS: Twenty-four percent of households were identified as dog-owning and 52% owned a pet of some type. Multivariable logistic regression suggested that households were more likely to own a dog if they had more occupants (five or more); if they had an adult female household member; or if they owned a horse. The age structure of the households was also associated with dog ownership, with households containing older children (between six and 19 years of age) and young adults (between 20 and 29 years of age), more likely to own dogs. We also found that dog owning households were more likely to be multi-dog households than single-dog if they also owned a cat or a bird, or if the household contained a person of 20–29 years old. Dog owners reported increased contact with dogs, other than their own, compared to those that did not own dogs and this contact appeared to be mainly through walking. CONCLUSION: Some household types are more likely to own a dog than others. This study supports the suggestion that dogs are more common in families who have older children (6–19 years), as has been generally observed in other countries. Dog owners are also more likely to have contact with dogs other than their own, compared with those not owning a dog

First Detection of HCO+^+ Absorption in the Magellanic System

We present the first detection of HCO$^+$ absorption in the Magellanic System. Using the Australia Telescope Compact Array (ATCA), we observed 9 extragalactic radio continuum sources behind the Magellanic System and detected HCO$^+$ absorption towards one source located behind the leading edge of the Magellanic Bridge. The detection is located at LSR velocity of $v=214.0 \pm 0.4\rm\,km\,s^{-1}$, with a full width at half maximum of $\Delta v=4.5\pm 1.0\rm\,km\,s^{-1}$ and optical depth of $\tau(\rm HCO^+)=0.10\pm 0.02$. Although there is abundant neutral hydrogen (HI) surrounding the sightline in position-velocity space, at the exact location of the absorber the HI column density is low, $<10^{20}\rm\,cm^{-2}$, and there is little evidence for dust or CO emission from Planck observations. While the origin and survival of molecules in such a diffuse environment remains unclear, dynamical events such as HI flows and cloud collisions in this interacting system likely play an important role.Comment: Accepted for publication in ApJ. 6 pages, 2 figures, 2 table

Subdomain Location of Mutations in Cardiac Actin Correlate with Type of Functional Change

Determining the molecular mechanisms that lead to the development of heart failure will help us gain better insight into the most costly health problem in the Western world. To understand the roles that the actin protein plays in the development of heart failure, we have taken a systematic approach toward characterizing human cardiac actin mutants that have been associated with either hypertrophic or dilated cardiomyopathy. Seven known cardiac actin mutants were expressed in a baculovirus system, and their intrinsic properties were studied. In general, the changes to the properties of the actin proteins themselves were subtle. The R312H variant exhibited reduced stability, with a Tm of 53.6°C compared to 56.8°C for WT actin, accompanied with increased polymerization critical concentration and Pi release rate, and a marked increase in nucleotide release rates. Substitution of methionine for leucine at amino acid 305 showed no impact on the stability, nucleotide release rates, or DNase-I inhibition ability of the actin monomer; however, during polymerization, a 2-fold increase in Pi release was observed. Increases to both the Tm and DNase-I inhibition activity suggested interactions between E99K actin molecules under monomer-promoting conditions. Y166C actin had a higher critical concentration resulting in a lower Pi release rate due to reduced filament-forming potential. The locations of mutations on the ACTC protein correlated with the molecular effects; in general, mutations in subdomain 3 affected the stability of the ACTC protein or affect the polymerization of actin filaments, while mutations in subdomains 1 and 4 more likely affect protein-protein interactions

A global view of the oncogenic landscape in nasopharyngeal carcinoma : an integrated analysis at the genetic and expression levels

Previous studies have reported that the tumour cells of nasopharyngeal carcinoma (NPC) exhibit recurrent chromosome abnormalities. These genetic changes are broadly assumed to lead to changes in gene expression which are important for the pathogenesis of this tumour. However, this assumption has yet to be formally tested at a global level. Therefore a genome wide analysis of chromosome copy number and gene expression was performed in tumour cells micro-dissected from the same NPC biopsies. Cellular tumour suppressor and tumour-promoting genes (TSG, TPG) and Epstein-Barr Virus (EBV)-encoded oncogenes were examined. The EBV-encoded genome maintenance protein EBNA1, along with the putative oncogenes LMP1, LMP2 and BARF1 were expressed in the majority of NPCs that were analysed. Significant downregulation of expression in an average of 76 cellular TSGs per tumour was found, whilst a per-tumour average of 88 significantly upregulated, TPGs occurred. The expression of around 60% of putative TPGs and TSGs was both up-and down-regulated in different types of cancer, suggesting that the simplistic classification of genes as TSGs or TPGs may not be entirely appropriate and that the concept of context-dependent onco-suppressors may be more extensive than previously recognised. No significant enrichment of TPGs within regions of frequent genomic gain was seen but TSGs were significantly enriched within regions of frequent genomic loss. It is suggested that loss of the FHIT gene may be a driver of NPC tumourigenesis. Notwithstanding the association of TSGs with regions of genomic loss, on a gene by gene basis and excepting homozygous deletions and high-level amplification, there is very little correlation between chromosomal copy number aberrations and expression levels of TSGs and TPGs in NPC

The correlation of early flow disturbances with the development of infrainguinal graft stenosis: A 10-year study of 341 autogenous vein grafts

AbstractPurpose: Although duplex surveillance of infrainguinal bypass grafts is widely accepted, the optimal frequency and intensity of graft surveillance remains controversial. Earlier reports have suggested that grafts can be stratified into high-risk and low-risk groups based on the presence or absence of early graft flow disturbances. The purpose of this study was to provide long-term data in determining whether early graft flow disturbances detected by means of duplex scanning can predict the development of intrinsic vein graft stenosis. Methods: We reviewed a series of patients undergoing prospective duplex graft surveillance after autogenous infrainguinal bypass grafting procedures from 1987 to 1997. Patients included in the study underwent at least one duplex scan within 3 months of graft implantation and were observed for a minimum of 6 months. Grafts were categorized as abnormal when a focal flow disturbance with a peak systolic velocity greater than 150 cm/s was identified within 3 months of graft implantation. Results: Of 341 vein grafts in 296 patients who met inclusion criteria, 89 grafts (26%) required revision for intrinsic stenosis; the mean follow-up period was 35 months (range, 6 months to 10 years). Early flow disturbances were detected in 84 (25%) grafts. Grafts with early flow disturbances were more likely to ultimately require revision (43% vs 21%; P = .0001) and required initial revision earlier (8 months vs 16 months; P = .019). Eighty-two percent of initial graft revisions occurred in the first 2 postoperative years; 69% occurred in the first year. However, an annual 2% to 4% incidence of late-appearing graft stenosis persisted during long-term follow-up. An additional 24 patients (7% of grafts) required an inflow or outflow reconstruction. Conclusion: Grafts with early postoperative flow disturbances detected by means of duplex scanning have nearly three times the incidence of graft-threatening stenosis and an earlier requirement for revision, when compared with normal grafts. This suggests that the biology and etiology of these lesions may differ. These data support not only aggressive efforts to detect early graft lesions to stratify grafts at highest risk, but also continued lifelong graft surveillance to detect late-appearing lesions, inflow and outflow disease progression, and maximize graft patency. (J Vasc Surg 1999;30:8-15.