Using of Binominal Method for the Purpose of Determination of Confidence Intervals for Prediction of Invasive Ductal Breast Carcinoma Metastases

The study was performed using surgical and biopsy material based on histopathological study, which was conducted at the Chernivtsy Regional Clinical Oncology Centre. In the cases of verified diagnosis of ductal breast carcinoma was studied the size of the primary tumour node and metastasis in lymphogenous features of regional lymph node according to classification system TNM. All cases were divided by categories T and N. Using statistical data was conducted the analysis in patients of verified diagnosis of ductal breast carcinoma in Chernivtsy region. We determined the features of metastasis to regional lymph nodes under according to the classification pTNM and confidence intervals calculated according to percent binomial method with p=0.05. After receiving the results the data were compared to predict metastasis. Using statistical data were conducted the analysis in women of Chernivtsi region with verified diagnosis of ductal breast cancer. We determined the features of metastasis classification according pTNM and confidence intervals of percent according to binominal method with p=0.05. All observations of histopathological conclusions were conducted on the basis of Chernivtsy Regional Clinical Oncology Centre

Non-Linear Identification of Judgmental Forecasts Effects at SKU-Level

Prediction of demand is a key component within supply chain management. Im- proved accuracy in forecasts affects directly all levels of the supply chain, reduc- ing stock costs and increasing customer satisfaction. In many application areas, demand prediction relies on statistical software which provides an initial forecast subsequently modified by the expert’s judgment. This paper outlines a new method- ology based on State Dependent Parameter (SDP) estimation techniques to identify the non-linear behaviour of such managerial adjustments. This non-parametric SDP estimate is used as a guideline to propose a non-linear model that corrects the bias introduced by the managerial adjustments. One-step-ahead forecasts of SKU sales sampled monthly from a manufacturing company are utilized to test the proposed methodology. The results indicate that adjustments introduce a non-linear pattern undermining accuracy. This understanding can be used to enhance the design of the Forecasting Support System in order to help forecasters towards more efficient judgmental adjustments

Sustainment of High-Beta Mirror Plasma by Neutral Beams

The report presents two experiments carried out in Budker Institute for obtaining the maximum plasma beta (ratio of the plasma pressure to magnetic field pressure) in axially symmetric magnetic field. The experiments are based on injection of powerful focused neutral beams with high neutral power density in the plasma. The produced fast ion population significantly increases the plasma pressure. It the axially symmetric GDT experiment (Gas Dynamic Trap) the plasma beta exceeded 0.6 at the fast ion turning points. The CAT experiment (Compact Axisymmetric Toroid) is being prepared for obtaining a plasmoid with extremely high diamagnetism in axially symmetric magnetic field. Reversal of magnetic field in the plasmoid is possible in this experiment

ACMEOLOGICAL APPROACH TO CAREER MANAGEMENT OF PEDAGOGICAL WORKERS

The article discusses the career management of teachers in the context of the acmeological approach and in the context of the emerging national system of teacher growth. The characteristic of the national system of teacher growth and its importance for ensuring the quality of education and career advancement of teachers is presented.В статье рассматривается управление карьерой педагогических работников в контексте акмеологического подхода и в условиях формирующейся национальной системы учительского роста. Представлена характеристика национальной системы учительского роста и ее значение для обеспечения качества образования и карьерного продвижения педагогических работников

Radiometric Bimolecular Beacons for Sensitive Detection of RNA in Single Living Cells

Numerous studies have utilized molecular beacons (MBs) to image RNA expression in living cells; however, there is growing evidence that the sensitivity of RNA detection is significantly hampered by their propensity to emit false-positive signals. To overcome these limitations, we have developed a new RNA imaging probe called ratiometric bimolecular beacon (RBMB), which combines functional elements of both conventional MBs and siRNA. Analogous to MBs, RBMBs elicit a fluorescent reporter signal upon hybridization to complementary RNA. In addition, an siRNA-like doublestranded domain is used to facilitate nuclear export. Accordingly, live-cell fluorescent imaging showed that RBMBs are localized predominantly in the cytoplasm, whereas MBs are sequestered into the nucleus. The retention of RBMBs within the cytoplasmic compartment led to \u3e15-fold reduction in false-positive signals and a significantly higher signal-to-background compared with MBs. The RBMBs were also designed to possess an optically distinct reference fluorophore that remains unquenched regardless of probe confirmation. This reference dye not only provided a means to track RBMB localization, but also allowed single cell measurements of RBMB fluorescence to be corrected for variations in probe delivery. Combined, these attributes enabled RBMBs to exhibit an improved sensitivity for RNA detection in living cells

Production of high brightness H- beam by charge exchange of hydrogen atom beam in sodium jet

Production of H{sup -} beam for accelerators applications by charge exchange of high brightness hydrogen neutral beam in a sodium jet cell is experimentally studied in joint BNL-BINP experiment. In the experiment, a hydrogen-neutral beam with 3-6 keV energy, equivalent current up to 5 A and 200 microsecond pulse duration is used. The atomic beam is produced by charge exchange of a proton beam in a pulsed hydrogen target. Formation of the proton beam is performed in an ion source by four-electrode multiaperture ion-optical system. To achieve small beam emittance, the apertures in the ion-optical system have small enough size, and the extraction of ions is carried out from the surface of plasma emitter with a low transverse ion temperature of {approx}0.2 eV formed as a result of plasma jet expansion from the arc plasma generator. Developed for the BNL optically pumped polarized ion source, the sodium jet target with recirculation and aperture diameter of 2 cm is used in the experiment. At the first stage of the experiment H{sup -} beam with 36 mA current, 5 keV energy and {approx}0.15 cm {center_dot} mrad normalized emittance was obtained. To increase H{sup -} beam current ballistically focused hydrogen neutral beam will be applied. The effects of H{sup -} beam space-charge and sodium-jet stability will be studied to determine the basic limitations of this approach

Plant wastes in wood concrete manufacturing

The urgency of plant waste application for effective construction materials is proved. It is proposed to manufacture concrete wood with a composite aggregate of a straw and flax boon mixture. Test results of main physical and mechanical characteristics are provided