The Relationship Between Oxidative Stress, Nitric Oxide, And Coronary Artery Disease

Aim: Oxidative stress and free radicals are known to have important roles in the development of atherosclerosis. Malondialdehyde (MDA), a carbonile group produced during lipid peroxidation, is used widely in determining oxidative stress. Nitric Oxide (NO) is a vasodilatator agent derived from the endothelium. The aim of our study was to investigate the relationship between MDA and NO in patient with coronary artery disease. Methods: Forty-five patients diagnosed with 50 % or more stenosis by coronary angiography were included in our study. Patients were separated as 1, 2 and 3 vessel-patients according to the number of vessels affected. Diabetics, smoking patients, patients with malignancy, renal and liver disease, and patients using nitrate preparation were excluded from the study. Forty-five healthy individuals, who had cardiological evaluation in the last year were identified as the control group. MDA, NO, and lipid measurements were performed accordingly. Results: Serum MDA levels were significantly higher in the CAD group when compared to the controls (p<0.001). No statistical difference was observed in terms of the spread of coronary artery disease and MDA levels. No significant relationship was determined between MDA and NO levels. NO was tended to be higher in the CAD group than the controls (p>0.05). No significant differences were observed in the comparison of NO levels between one, two and three vessel patients. NO levels were significantly higher in hypertensive CAD patients than the normotensive ones (p<0.05). Conclusion: In our study, MDA levels showed highly significant relation with coronary artery disease and NO serum levels were mildly increased in the patient group, however, MDA and NO showed no significant relation. The high MDA levels among all patients with CAD demonstrate a strong relationship between the oxidative stress and the coronary artery disease

The importance of the management of anaesthesia during surgery for sacrococcygeal teratoma in the newborn Sakrokoksigeal teratomlu yenidoǧanda ameliyat esnasi{dotless}nda anestezi yönetiminin önemi

Sacrococcygeal teratoma is the most common germ cell tumor in newborn infants. Teratomas with unknown etiology can cause problems in the management of surgery and anaesthesia during operation since they can reach high pressure levels due to increased blood supply. A sacrococcygeal teratoma was diagnosed with prenatal ultrasound and a 4050 g 40 week newborn, was born with C/S. The physical examination was unremarkable except for a solid mass the size of 15x10 cm in the sacrococcygeal region. Preoperative anaesthesia examination of the case was within normal limits and at the second day of her life the mass was excised. The invasive arterial and central venous pressures with esophageal temperature monitorization was assured and severe bradycardia, hypotension, and hypoxemia developed during the operation. With close invasive monitorization, the changes were realised immediately and treated effectively. The importance of invasive arterial and venous pressure monitoring in patients operated on during the neonatal period with giant sacrococcygeal teratoma, is highlighted in this report

Daily Practice of Mechanical Ventilation and Weaning in Turkish PICUs: A Multicenter Prospective Survey

Objectives