The effect of sertraline and 8-OH-DPAT on the PTZinduced seizure threshold: Role of the nitrergic system

Purpose Serotonin is a key regulatory neurotransmitter in the CNS which plays an important role in seizure through different receptors, especially the 5HT1A subtype. The role of sertraline through the 5HT1A receptor and nitric oxide interaction on the PTZ-induced seizure threshold was investigated in this study. Method In this study, 70 white male mice were randomly divided into 10 groups including intact control, sham-control and eight experimental groups which received sertraline, 8-OH-DPAT, WAY100635, WAY100635 + sertraline, WAY100635 + 8-OH-DPAT, L-NAME, L-NAME + sertraline and L-NAME + 8-OH-DPAT. After 14 days of treatment in different groups, the PTZ-induced seizure threshold was assessed and the measurement of nitric oxide metabolites in the brain tissue was done with the Greiss method. Results The seizure threshold was significantly increased in the sertraline and 8OH-DPAT receiving groups compared to the sham group (P < 0.001). In the presence of WAY100635, the effect of both sertraline and 8-OH-DPAT in raising the seizure threshold was more prominent (P < 0.001) but on the other hand, in the presence of L-NAME, an increase in the anticonvulsant effect of 8-OH-DPAT was observed, while L-NAME alone had no effect on the seizure threshold (P < 0.001). The NOX concentration was significantly decreased in the 8-OH-DPATtreated group (P < 0.01), while the WAY100657 reversed it and the combination of 8-OH-DPAT with L-NAME reduced the NOX levels (P < 0.001). Conclusions These findings support the anticonvulsant effect of SSRIs and selective 5HT1A receptors, although serotonin receptors other than 5HT1A subtype may be involved and also it is probable that some anticonvulsant effects of the sertraline and 8-OH-DPAT are through the modulation of nitrergic system. © 2016 British Epilepsy Associatio

Lagrangian tracers on a surface flow: the role of time correlations

Finite time correlations of the velocity in a surface flow are found to be important for the formation of clusters of Lagrangian tracers. The degree of clustering characterized by the Lyapunov spectrum of the flow is numerically shown to be in qualitative agreement with the predictions for the white-in-time compressible Kraichnan flow, but to deviate quantitatively. For intermediate values of compressibility the clustering is surprisingly weakened by time correlations.Comment: 4 pages, 5 figures, to be published in PR

Single-particle and collective excitations in a charged Bose gas at finite temperature

The main focus of this work is on the predictions made by the dielectric formalism in regard to the relationship between single-particle and collective excitation spectra in a gas of point-like charged bosons at finite temperature $T$ below the critical region of Bose-Einstein condensation. Illustrative numerical results at weak coupling ($r_s = 1$) are presented within the Random Phase Approximation. We show that within this approach the single-particle spectrum forms a continuum extending from the transverse to the longitudinal plasma mode frequency and leading to a double-peak structure as $T$ increases, whereas the density fluctuation spectrum consists of a single broadening peak. We also discuss the momentum distribution and the superfluidity of the gas.Comment: 15 pages, 5 figure

Application Procedures and Practices Futures Human Resource Planning

The most effective element of human resource development and organization of their most valuable asset is of very high importance of the human resource planning and extension and improvement of the level of complexity on the other hand, the progress, the amazing growth of technology, communications, and changes in the period and the emergence of new current problems in the International community, planning methods based on predictions somewhat dumb enough to not seem unreasonable and meet the real needs of the micro and macro levels is not.The inability to accurately predict the future and the growing complexity of the changes made The researchers took advantage of the capabilities and benefits of futures and fixed as it is necessary for planning and forecasting of scientific developments and the political, military, technology, consider.Future research into the human ability to imagine a future issue are considered and makes progress.Future studies, systematic process to identify opportunities and future needs, and to assist major organizations in making decisions, so future studies approach quickly spread among the communities and organizations and special place different areas of science, so in this article has been tried and tested techniques and methods of futures research and application of each of these methods in the field of human resource planning, which can be crucial in the development and promotion organization is explained and described

Early real-time estimation of the basic reproduction number of emerging or reemerging infectious diseases in a community with heterogeneous contact pattern: Using data from Hong Kong 2009 H1N1 Pandemic Influenza as an illustrative example

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