Current state and prospects for development of internet advertising in Kazakhstan

The world experience in the development of Internet advertising is summarized and systematized, the possibilities of its application and adaptation to the conditions of Kazakhstan are considered. The authors suggest innovative advertising technologies for Kazakhstani companies and advertising agencies. New formats and kinds of advertising tools give opportunities to expend budgets of companies more effectively, improving the quality of advertising as a whole, therefore to promote their goods and services more effectively. The implementation of the proposed recommendations will enrich the Kazakhstan’s science and raise advertising to a new level, it will be actively used in marketers’ work, will help popularize the new communication tools of Internet advertising, attract customers’ attention and promote goods and services of Kazakhstani companies more effectively with low budget.peer-reviewe

Pretsedent nomlarning o’zbek va ingliz badiiy matnlaridagi o’rni

Ushbu maqolada pretsedent nomlar badiiy matnlarda turli maqsadlarda qo’llanilishi tahlil qilinadi

Theoretical Studies of the Structure of the Metal-carbon Composites on the Base of Acryle-nitrile Nanopolimer

The presence of the metal compounds in the acryle-nitrile nanopolimer (PPAN) leads to the formation of the metal nanoparticles. The metal-carbon nanocomposites based on PPAN including pair connections with iron and cobalt has been theoretically investigated. The spatial configuration of the nanocomposite for each option of the arrangement of metal atoms has been received. The analysis of the received results for all options of the arrangement of the metal atoms allowed defining the binding energy of the systems and the width of the forbidden gap ΔЕg of the nanocomposite. The analysis of the electronic and energy struc-tures of the system found out that the introduction of the metal atoms leaded to the essential reduction of the width of the forbidden zone of the composite in comparison with the pure PPAN. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3628

Thermodynamic-diagram analysis of the Fe-Si-Al-Cr system with the construction of diagrams of phase relations

The Fe-Cr-Si and Fe-Cr-Al systems are the basic ones in the development of the technology for smelting a new complex alloy - aluminosilicochrome. Aluminosilicochromium can be used as a reducing agent for metallothermic production of low- and medium-carbon ferrochromium grades with subsequent use in the smelting of stainless steel grades. Construction of a diagram of the phase composition of a four-component system Fe-Si-Al-Cr, consisting of 4 three-component systems Fe-Si-Al, Fe-Cr-Si, Fe-Cr-Al, Si-Cr-Al. Three-component Fe-Si-Al system, which will be the base of the Fe-Si-Al-Cr tetrahedron. It is necessary to analyze the thermodynamic properties of compounds for binary and ternary systems

MODEL OF INNOVATIVE PROCESSES IN LOGISTIZATION

The study analyzes the actual problems of the logistics business processes of trade enterprises. A survey of respondents allows you to identify the most significant problems and get their development according to the method

Boron Monolayer χ3-type. Formation of the Vacancy Defect and Pinhole

This research is focused on a local vacancy defect formation and pinholes formation in a two-dimensional boron structure – boron monolayer χ3 - type. The main characteristics of defects formation have been carried out by using the semi-empirical quantum-chemical scheme MNDO. The variants of atomic configurations which give pinholes defect have been found

Modelling of the process of burning coke on catalyst grain

Based on the kinetic model of oxidative regeneration of coked catalysts, a two phases diffusion mathematical model of the process of oxidative regeneration of coked catalysts in a catalyst grain has been enhanced. A numerical analysis of the heating on the grain was carried out over a wide range of the initial oxygen concentration, inlet temperature, and gas flow velocity. It is established that the process of burning coke has a high parametric sensitivity to the initial oxygen concentration

Cytokinesproduction by blood immune cells in patients of different age groups with invasive ductal carcinoma of no special type and lymphatic metastases

The aim of this study was to evaluate production of cytokines by the blood immune cells in patients of different age groups with invasive non-specified type mammary ductal carcinoma, with or without metastases. Production of cytokines by periphery blood immunocompetent cells, either spontaneous and stimulated with polyclonal activators, was assessed in 82 patients with invasive mammary ductal carcinoma. The concentrations of IL-6, IL-8, IL-10, IL-17, IL-18, IL-1p, IL-1ra, TNFa, IFNy, G-CSF, GM-CSF, VEGF и MCP-1 were determined by solid-phase enzyme-linked immunosorbent assay. The patients were divided into 2 age groups: the first group consisted of 48 patients from 45 to 60 years old; the second group consisted of 34 older patients (61 to 75 years old). Metastases in local lymph nodes were documented in twenty patients from the first group and nine patients from the second group. The younger patients (45-60 years old) with metastases in local lymph nodes showed higher polyclonal activation index of IL-4 and IL-1ra production, when compared to the patients without lymphatic metastases. As for the older patients (61 to 75 years old), their polyclonal activation index of IL-6, IL-8, IL-1ra, G-CFS, GM-CSF production was significantly lower in cases of local lymph nodes metastases. The latter was due to higher level of spontaneous production, which suppressed the influence of polyclonal activators. The index of polyclonal activation upon production of cytokines in patients with lymphatic metastases was shown to be significantly higher for the age group of 45 to 60 years than in the age group of 61 to 75 years old. This fact suggested a highly stimulating effect of polyclonal activators in patients younger than 60 years. It was found that correlation between the index of polyclonal activation of cytokine production, and the indexes of ER, PR, HER2/NEU and Ki-67 receptor expression, which are used for the determination of molecular genetic subtype of the tumor, differ significantly for the distinct age groups

Characterization of Dysbiotic Changes of Skin Microbiota in Contact Sports Athletes

© 2017, Springer Science+Business Media New York.Contact sports athletes often suffer from various skin disorders (inflammatory diseases of bacterial and fungal origin, atopic dermatitis, psoriasis, etc.) resulting in long breaks in training which ruin athletic performance. Wrestling implies intense skin-to-skin contact that creates perfect conditions for transmission of the infectious agents. Following the standard rules of hygiene (showering and handwashing directly after each competition and training) does not exclude the possibility to get an infection from sparring partner. To characterize the skin microbial composition of wrestlers who do not have current manifestation of any skin disorders, the metagenomic analysis was performed. Absolute predominance of Bacillus genus in metagenomic profiles of wrestlers’ skin was observed in contrast with the existing literature data. Classic microbiological approaches allowed to detect hemolytic forms of microorganisms. Wrestlers’ skin appeared to be colonized with hemolytic bacilli, whereas the non-wrestler athletes did not have such bacteria on their skin. Such dysbiotic shifts in the microbial community may cause the emergence of skin diseases. Revealed properties could help to design highly effective antiseptics for the contact sports hygiene

A Polyadenylation Factor Subunit Implicated in Regulating Oxidative Signaling in Arabidopsis thaliana

BACKGROUND: Plants respond to many unfavorable environmental conditions via signaling mediated by altered levels of various reactive oxygen species (ROS). To gain additional insight into oxidative signaling responses, Arabidopsis mutants that exhibited tolerance to oxidative stress were isolated. We describe herein the isolation and characterization of one such mutant, oxt6. METHODOLOGY/PRINCIPAL FINDINGS: The oxt6 mutation is due to the disruption of a complex gene (At1g30460) that encodes the Arabidopsis ortholog of the 30-kD subunit of the cleavage and polyadenylation specificity factor (CPSF30) as well as a larger, related 65-kD protein. Expression of mRNAs encoding Arabidopsis CPSF30 alone was able to restore wild-type growth and stress susceptibility to the oxt6 mutant. Transcriptional profiling and single gene expression studies show elevated constitutive expression of a subset of genes that encode proteins containing thioredoxin- and glutaredoxin-related domains in the oxt6 mutant, suggesting that stress can be ameliorated by these gene classes. Bulk poly(A) tail length was not seemingly affected in the oxt6 mutant, but poly(A) site selection was different, indicating a subtle effect on polyadenylation in the mutant. CONCLUSIONS/SIGNIFICANCE: These results implicate the Arabidopsis CPSF30 protein in the posttranscriptional control of the responses of plants to stress, and in particular to the expression of a set of genes that suffices to confer tolerance to oxidative stress