Hormone replacement therapy

Martha Hickey, Jane Elliott, Sonia Louise Daviso

Statistical Modeling of Spatial Extremes

The areal modeling of the extremes of a natural process such as rainfall or temperature is important in environmental statistics; for example, understanding extreme areal rainfall is crucial in flood protection. This article reviews recent progress in the statistical modeling of spatial extremes, starting with sketches of the necessary elements of extreme value statistics and geostatistics. The main types of statistical models thus far proposed, based on latent variables, on copulas and on spatial max-stable processes, are described and then are compared by application to a data set on rainfall in Switzerland. Whereas latent variable modeling allows a better fit to marginal distributions, it fits the joint distributions of extremes poorly, so appropriately-chosen copula or max-stable models seem essential for successful spatial modeling of extremes.Comment: Published in at http://dx.doi.org/10.1214/11-STS376 the Statistical Science (http://www.imstat.org/sts/) by the Institute of Mathematical Statistics (http://www.imstat.org

Rejoinder to "Statistical Modeling of Spatial Extremes"

Rejoinder to "Statistical Modeling of Spatial Extremes" by A. C. Davison, S. A. Padoan and M. Ribatet [arXiv:1208.3378].Comment: Published in at http://dx.doi.org/10.1214/12-STS376REJ the Statistical Science (http://www.imstat.org/sts/) by the Institute of Mathematical Statistics (http://www.imstat.org

Post-Impact Thermal Evolution of Porous Planetesimals

Impacts between planetesimals have largely been ruled out as a heat source in the early Solar System, by calculations that show them to be an inefficient heat source and unlikely to cause global heating. However, the long-term, localized thermal effects of impacts on planetesimals have never been fully quantified. Here, we simulate a range of impact scenarios between planetesimals to determine the post-impact thermal histories of the parent bodies, and hence the importance of impact heating in the thermal evolution of planetesimals. We find on a local scale that heating material to petrologic type 6 is achievable for a range of impact velocities and initial porosities, and impact melting is possible in porous material at a velocity of > 4 km/s. Burial of heated impactor material beneath the impact crater is common, insulating that material and allowing the parent body to retain the heat for extended periods (~ millions of years). Cooling rates at 773 K are typically 1 - 1000 K/Ma, matching a wide range of measurements of metallographic cooling rates from chondritic materials. While the heating presented here is localized to the impact site, multiple impacts over the lifetime of a parent body are likely to have occurred. Moreover, as most meteorite samples are on the centimeter to meter scale, the localized effects of impact heating cannot be ignored.Comment: 38 pages, 9 figures, Revised for Geochimica et Cosmochimica Acta (Sorry, they do not accept LaTeX

Following microscopic motion in a two dimensional glass-forming binary fluid

The dynamics of a binary mixture of large and small discs are studied at temperatures approaching the glass transition using an analysis based on the topology of the Voronoi polygon surrounding each atom. At higher temperatures we find that dynamics is dominated by fluid-like motion that involves particles entering and exiting the nearest-neighbour shells of nearby particles. As the temperature is lowered, the rate of topological moves decreases and motion becomes localised to regions of mixed pentagons and heptagons. In addition we find that in the low temperature state particles may translate significant distances without undergoing changes in their nearest neig hbour shell. These results have implications for dynamical heterogeneities in glass forming liquids.Comment: 12 pages, 7 figure

Phase equilibrium modeling for high temperature metallization on GaAs solar cells

Recent trends in performance specifications and functional requirements have brought about the need for high temperature metallization technology to be developed for survivable DOD space systems and to enhance solar cell reliability. The temperature constitution phase diagrams of selected binary and ternary systems were reviewed to determine the temperature and type of phase transformation present in the alloy systems. Of paramount interest are the liquid-solid and solid-solid transformations. Data are being utilized to aid in the selection of electrical contact materials to gallium arsenide solar cells. Published data on the phase diagrams for binary systems is readily available. However, information for ternary systems is limited. A computer model is being developed which will enable the phase equilibrium predictions for ternary systems where experimental data is lacking

The pancreatic-polypeptide family of peptides: their role in the brain-gut axis

In this volume of Biomedical Reviews, Rogers and Hermann present an interesting model for the regulation of gastrointestinal function by two peptides, neuropeptide Y (NPY), and peptide YY (PYY), both of which belong to a related group of peptides known as the pancreatic polypeptide (PP)-fold family of peptides. In this review, largely of their own innovative work, they develop the hypothesis that PYY, acting as a humoral (hormonal) agent, may be a major inhibitory factor in the regulation of the upper gastrointestinal tract. In contrast, NPY would appear to be a major excitatory transmitter. How can two structurally homologous peptides produce such divergent actions?Biomedical Reviews 1997; 8: 70-72