Spatially resolved variations of the IMF mass normalization in early-type galaxies as probed by molecular gas kinematics

We here present the first spatially-resolved study of the IMF in external galaxies derived using a dynamical tracer of the mass-to-light ratio. We use the kinematics of relaxed molecular gas discs in seven early-type galaxies (ETGs) selected from the ATLAS3D survey to dynamically determine mass-to-light ratio (M/L) gradients. These M/L gradients are not very strong in the inner parts of these objects, and galaxies that do show variations are those with the highest specific star formation rates. Stellar population parameters derived from star formation histories are then used in order to estimate the stellar initial mass function function (IMF) mismatch parameter, and shed light on its variation within ETGs. Some of our target objects require a light IMF, otherwise their stellar population masses would be greater than their dynamical masses. In contrast, other systems seem to require heavier IMFs to explain their gas kinematics. Our analysis again confirms that IMF variation seems to be occurring within massive ETGs. We find good agreement between our IMF normalisations derived using molecular gas kinematics and those derived using other techniques. Despite this, we do not see find any correlation between the IMF normalisation and galaxy dynamical properties or stellar population parameters, either locally or globally. In the future larger studies which use molecules as tracers of galaxy dynamics can be used to help us disentangle the root cause of IMF variation

Relative incidence and predictors of pulmonary arterial hypertension complicating type 2 diabetes: The Fremantle Diabetes Study Phase I

Aims: To determine the relative incidence and predictors of pulmonary arterial hypertension (PAH) in type 2 diabetes. Methods: Hospitalizations for/with and death from/with PAH, and all-cause mortality, were ascertained from validated databases for participants from the longitudinal, community-based Fremantle Diabetes Study Phase I (FDS1; n = 1287) and age-, sex- and zip code-matched people without diabetes (n = 5153) between entry (1993–1996) and end-2017. Incidence rates (IRs) and IR ratios (IRRs) were calculated. Cox proportional hazards and competing risk models generated cause-specific (cs) and subdistribution (sd) hazard ratios (HRs) for incident PAH. Results: In the pooled cohort (mean age 64.0 years, 49% males), 49 (3.8%) of the type 2 diabetes participants and 133 (2.6%) of those without diabetes developed PAH during 106,556 person-years of follow-up (IRs (95% CI) 262 (194– 346) and 151 (127–179) /100,000 person-years, respectively; IRR 1.73 (1.22–2.42), P = 0.001). Type 2 diabetes was associated with an unadjusted csHR of 1.97 (1.42–2.74) and sdHR of 1.44 (1.04–2.00) (P ≤ 0.03); after adjustment for age, sex, and co-morbidities, these were 1.43 (0.83–2.47) and 1.36 (0.97–1.91), respectively (P ≥ 0.07). Conclusions: Type 2 diabetes is associated with an increased risk of PAH but this is no longer significant after adjustment for other explanatory variables and the competing risk of death. © 2020 Elsevier Inc. All rights reserved

Subcellular mRNA localisation at a glance.

mRNA localisation coupled to translational regulation provides an important means of dictating when and where proteins function in a variety of model systems. This mechanism is particularly relevant in polarised or migrating cells. Although many of the models for how this is achieved were first proposed over 20 years ago, some of the molecular details are still poorly understood. Nevertheless, advanced imaging, biochemical and computational approaches have started to shed light on the cis-acting localisation signals and trans-acting factors that dictate the final destination of localised transcripts. In this Cell Science at a Glance article and accompanying poster, we provide an overview of mRNA localisation, from transcription to degradation, focusing on the microtubule-dependent active transport and anchoring mechanism, which we will use to explain the general paradigm. However, it is clear that there are diverse ways in which mRNAs become localised and target protein expression, and we highlight some of the similarities and differences between these mechanisms.This work was supported by a Wellcome Trust Senior Research Fellowship to I.D. supporting R.M.P. [grant number: 096144], a studentship from the Wellcome Trust to A.D. [grant number: 097304], the University of Cambridge, ISSF to T.T.W. [grant number 097814].This is the final version of the article. It first appeared from the Company of Biologists via http://dx.doi.org/10.1242/jcs.11427

Clinical and parasitological response to oral chloroquine and primaquine in uncomplicated human Plasmodium knowlesi infections

Background: Plasmodium knowlesi is a cause of symptomatic and potentially fatal infections in humans. There are no studies assessing the detailed parasitological response to treatment of knowlesi malaria infections in man and whether antimalarial resistance occurs. Methods: A prospective observational study of oral chloroquine and primaquine therapy was conducted in consecutive patients admitted to Kapit Hospital, Sarawak, Malaysian Borneo with PCR-confirmed single P. knowlesi infections. These patients were given oral chloroquine for three days, and at 24 hours oral primaquine was administered for two consecutive days, primarily as a gametocidal agent. Clinical and parasitological responses were recorded at 6-hourly intervals during the first 24 hours, daily until discharge and then weekly to day 28. Vivax malaria patients were studied as a comparator group. Results: Of 96 knowlesi malaria patients who met the study criteria, 73 were recruited to an assessment of the acute response to treatment and 60 completed follow-up over 28 days. On admission, the mean parasite stage distributions were 49.5%, 41.5%, 4.0% and 5.6% for early trophozoites, late trophozoites, schizonts and gametocytes respectively. The median fever clearance time was 26.5 [inter-quartile range 16-34] hours. The mean times to 50% (PCT50) and 90% (PCT90) parasite clearance were 3.1 (95% confidence intervals [CI] 2.8-3.4) hours and 10.3 (9.4-11.4) hours. These were more rapid than in a group of 23 patients with vivax malaria 6.3 (5.3-7.8) hours and 20.9 (17.6-25.9) hours; P = 0.02). It was difficult to assess the effect of primaquine on P. knowlesi parasites, due to the rapid anti-malarial properties of chloroquine and since primaquine was administered 24 hours after chloroquine. No P. knowlesi recrudescences or re-infections were detected by PCR. Conclusions: Chloroquine plus primaqine is an inexpensive and highly effective treatment for uncomplicated knowlesi malaria infections in humans and there is no evidence of drug resistance. Further studies using alternative anti-malarial drugs, including artemisinin derivatives, would be desirable to define optimal management strategies for P. knowlesi.Publisher PDFPeer reviewe

A Supercooled Spin Liquid State in the Frustrated Pyrochlore Dy2Ti2O7

A "supercooled" liquid develops when a fluid does not crystallize upon cooling below its ordering temperature. Instead, the microscopic relaxation times diverge so rapidly that, upon further cooling, equilibration eventually becomes impossible and glass formation occurs. Classic supercooled liquids exhibit specific identifiers including microscopic relaxation times diverging on a Vogel-Tammann-Fulcher (VTF) trajectory, a Havriliak-Negami (HN) form for the dielectric function, and a general Kohlrausch-Williams-Watts (KWW) form for time-domain relaxation. Recently, the pyrochlore Dy2Ti2O7 has become of interest because its frustrated magnetic interactions may, in theory, lead to highly exotic magnetic fluids. However, its true magnetic state at low temperatures has proven very difficult to identify unambiguously. Here we introduce high-precision, boundary-free magnetization transport techniques based upon toroidal geometries and gain a fundamentally new understanding of the time- and frequency-dependent magnetization dynamics of Dy2Ti2O7. We demonstrate a virtually universal HN form for the magnetic susceptibility, a general KWW form for the real-time magnetic relaxation, and a divergence of the microscopic magnetic relaxation rates with precisely the VTF trajectory. Low temperature Dy2Ti2O7 therefore exhibits the characteristics of a supercooled magnetic liquid; the consequent implication is that this translationally invariant lattice of strongly correlated spins is evolving towards an unprecedented magnetic glass state, perhaps due to many-body localization of spin.Comment: Version 2 updates: added legend for data in Figures 4A and 4B; corrected equation reference in caption for Figure 4

Evidence of boosted 13CO/12CO ratio in early-type galaxies in dense environments

We present observations of $^{13}$CO(1-0) in 17 Combined Array for Research in Millimeter Astronomy (CARMA) Atlas3D early-type galaxies (ETGs), obtained simultaneously with $^{12}$CO(1-0) observations. The $^{13}$CO in six ETGs is sufficiently bright to create images. In these 6 sources, we do not detect any significant radial gradient in the $^{13}$CO/$^{12}$CO ratio between the nucleus and the outlying molecular gas. Using the $^{12}$CO channel maps as 3D masks to stack the $^{13}$CO emission, we are able to detect 15/17 galaxies to $>3\sigma$ (and 12/17 to at least 5$\sigma$) significance in a spatially integrated manner. Overall, ETGs show a wide distribution of $^{13}$CO/$^{12}$CO ratios, but Virgo cluster and group galaxies preferentially show a $^{13}$CO/$^{12}$CO ratio about 2 times larger than field galaxies, although this could also be due to a mass dependence, or the CO spatial extent ($R_{\rm CO}/R_{\rm e}$). ETGs whose gas has a morphologically-settled appearance also show boosted $^{13}$CO/$^{12}$CO ratios. We hypothesize that this variation could be caused by (i) the extra enrichment of gas from molecular reprocessing occurring in low-mass stars (boosting the abundance of $^{13}$C to $^{12}$C in the absence of external gas accretion), (ii) much higher pressure being exerted on the midplane gas (by the intracluster medium) in the cluster environment than in isolated galaxies, or (iii) all but the densest molecular gas clumps being stripped as the galaxies fall into the cluster. Further observations of $^{13}$CO in dense environments, particularly of spirals, as well as studies of other isotopologues, should be able to distinguish between these hypotheses.Comment: 13 pages, 3 tables, 7 figures, accepted by MNRA

Localized Translation of gurken/TGF-α mRNA during Axis Specification Is Controlled by Access to Orb/CPEB on Processing Bodies.

In Drosophila oocytes, gurken/TGF-α mRNA is essential for establishing the future embryonic axes. gurken remains translationally silent during transport from its point of synthesis in nurse cells to its final destination in the oocyte, where it associates with the edge of processing bodies. Here we show that, in nurse cells, gurken is kept translationally silent by the lack of sufficient Orb/CPEB, its translational activator. Processing bodies in nurse cells have a similar protein complement and ultrastructure to those in the oocyte, but they markedly less Orb and do not associate with gurken mRNA. Ectopic expression of Orb in nurse cells at levels similar to the wild-type oocyte dorso-anterior corner at mid-oogenesis is sufficient to cause gurken mRNA to associate with processing bodies and translate prematurely. We propose that controlling the spatial distribution of translational activators is a fundamental mechanism for regulating localized translation.This work was supported by a studentship from the Wellcome Trust (grant 097304 to A.D.), a Wellcome Trust Senior Research Fellowship (grant 096144 to I.D and supporting R.M.P), the University of Cambridge, ISSF (grant 097814 to T.T.W), and Wellcome Trust Strategic Awards 091911 and 107457 supporting advanced microscopy at Micron Oxford (http://micronoxford.com).This is the author accepted manuscript. The final version is available from Cell Press via http://dx.doi.org/10.1016/j.celrep.2016.02.03

Star Formation in Nearby Early-Type Galaxies: The Radio Continuum Perspective

We present a 1.4 GHz Karl G. Jansky Very Large Array (VLA) study of a sample of early-type galaxies (ETGs) from the volume- and magnitude-limited ATLAS-3D survey. The radio morphologies of these ETGs at a resolution of 5" are diverse and include sources that are compact on sub-kpc scales, resolved structures similar to those seen in star-forming spiral galaxies, and kpc-scale radio jets/lobes associated with active nuclei. We compare the 1.4 GHz, molecular gas, and infrared (IR) properties of these ETGs. The most CO-rich ATLAS-3D ETGs have radio luminosities consistent with extrapolations from H_2-mass-derived star formation rates from studies of late-type galaxies. These ETGs also follow the radio-IR correlation. However, ETGs with lower molecular gas masses tend to have less radio emission relative to their CO and IR emission compared to spirals. The fraction of galaxies in our sample with high IR-radio ratios is much higher than in previous studies, and cannot be explained by a systematic underestimation of the radio luminosity due to the presence extended, low-surface-brightness emission that was resolved-out in our VLA observations. In addition, we find that the high IR-radio ratios tend to occur at low IR luminosities, but are not associated with low dynamical mass or metallicity. Thus, we have identified a population of ETGs that have a genuine shortfall of radio emission relative to both their IR and molecular gas emission. A number of mechanisms may conspire to cause this radio deficiency, including a bottom-heavy stellar initial mass function, weak magnetic fields, a higher prevalence of environmental effects compared to spirals and enhanced cosmic ray losses.Comment: accepted for publication in MNRA