Incorporación de la ceniza de madera como filler para la elaboración del concreto f´c: 210kg/cm2, Piura 2022

La presente investigación tiene como finalidad ayudar de manera favorable en el cuidado del medio ambiente, ya que al utilizar este desecho estamos minimizando el impacto al medio ambiente. De tal manera nuestra investigación se caracteriza por ser de tipo aplicada y diseño experimental, donde se realizará un diseño de mezclas para la obtener un concreto convencional F’c=210 kg/cm2 con Cemento Pacasmayo (Tipo Ms), agregado grueso de la Cantera María José del Norte “Sojo”, y agregado fino de la Cantera “Cerromocho”. En la investigación se propone el uso de la ceniza de madera como material sustituyente del cemento para la elaboración de concreto. Tiene como objetivo Evaluar la incorporación de la ceniza de madera como filler en la elaboración de concreto f´c=210kg/cm2. Luego de adquirir todos los materiales a utilizar, se realizó el diseño del concreto f’c= 210 kg/cm² para luego realizar los cálculos de sustitución de ceniza por cemento, seguidamente se hizo el vaciado de las 36 probetas, curándolas en un tiempo de 7, 14 y 28 días; Por lo tanto, se concluye que al reemplazar al 5% de cemento por ceniza la resistencia que se obtuvo a los tres periodos de curado fueron las siguientes: f’c= 163 kg/cm2, f’c= 214 kg/cm2 y f’c= 235 kg/cm2 a los 7,14 y 28 días de curado, al reemplazar el 10% de cemento por ceniza la resistencia que se obtuvo a los tres periodos de curado fueron las siguientes: f’c=159kg/cm2, f’c=206kg/cm2 y f’c=229 kg/cm2 a los 7,14 y 28 días de curado y al reemplazar el 15% de cemento por ceniza la resistencia del concreto disminuyo en comparación al concreto convencional donde se obtuvo una resistencia de f’c=159kg/cm2, f’c=206kg/cm2 y f’c=229 kg/cm2 a los 7, 14 y 28 días de curado. De tal manera la proporción adecuada que se debe emplear para la elaboración de concreto f’c=210kg/cm2 es adicionando el 10% de ceniza de madera en reemplazo parcial del cemento

Identification and utilization of arbitrary correlations in models of recombination signal sequences

BACKGROUND: A significant challenge in bioinformatics is to develop methods for detecting and modeling patterns in variable DNA sequence sites, such as protein-binding sites in regulatory DNA. Current approaches sometimes perform poorly when positions in the site do not independently affect protein binding. We developed a statistical technique for modeling the correlation structure in variable DNA sequence sites. The method places no restrictions on the number of correlated positions or on their spatial relationship within the site. No prior empirical evidence for the correlation structure is necessary. RESULTS: We applied our method to the recombination signal sequences (RSS) that direct assembly of B-cell and T-cell antigen-receptor genes via V(D)J recombination. The technique is based on model selection by cross-validation and produces models that allow computation of an information score for any signal-length sequence. We also modeled RSS using order zero and order one Markov chains. The scores from all models are highly correlated with measured recombination efficiencies, but the models arising from our technique are better than the Markov models at discriminating RSS from non-RSS. CONCLUSIONS: Our model-development procedure produces models that estimate well the recombinogenic potential of RSS and are better at RSS recognition than the order zero and order one Markov models. Our models are, therefore, valuable for studying the regulation of both physiologic and aberrant V(D)J recombination. The approach could be equally powerful for the study of promoter and enhancer elements, splice sites, and other DNA regulatory sites that are highly variable at the level of individual nucleotide positions

Prospective Estimation of Recombination Signal Efficiency and Identification of Functional Cryptic Signals in the Genome by Statistical Modeling

The recombination signals (RS) that guide V(D)J recombination are phylogenetically conserved but retain a surprising degree of sequence variability, especially in the nonamer and spacer. To characterize RS variability, we computed the position-wise information, a measure correlated with sequence conservation, for each nucleotide position in an RS alignment and demonstrate that most position-wise information is present in the RS heptamers and nonamers. We have previously demonstrated significant correlations between RS positions and here show that statistical models of the correlation structure that underlies RS variability efficiently identify physiologic and cryptic RS and accurately predict the recombination efficiencies of natural and synthetic RS. In scans of mouse and human genomes, these models identify a highly conserved family of repetitive DNA as an unexpected source of frequent, cryptic RS that rearrange both in extrachromosomal substrates and in their genomic context

Multiple, conserved cryptic recombination signals in VH gene segments: detection of cleavage products only in pro–B cells

Receptor editing is believed to play the major role in purging newly formed B cell compartments of autoreactivity by the induction of secondary V(D)J rearrangements. In the process of immunoglobulin heavy (H) chain editing, these secondary rearrangements are mediated by direct VH-to-JH joining or cryptic recombination signals (cRSs) within VH gene segments. Using a statistical model of RS, we have identified potential cRSs within VH gene segments at conserved sites flanking complementarity-determining regions 1 and 2. These cRSs are active in extrachromosomal recombination assays and cleaved during normal B cell development. Cleavage of multiple VH cRSs was observed in the bone marrow of C57BL/6 and RAG2:GFP and μMT congenic animals, and we determined that cRS cleavage efficiencies are 30–50-fold lower than a physiological RS. cRS signal ends are abundant in pro–B cells, including those recovered from μMT mice, but undetectable in pre– or immature B cells. Thus, VH cRS cleavage regularly occurs before the generation of functional preBCR and BCR. Conservation of cRSs distal from the 3′ end of VH gene segments suggests a function for these cryptic signals other than VH gene replacement

Influencia de la adición de ceniza de cascarilla de arroz en las propiedades mecánicas de un concreto hidráulico para un pavimento rígido, Trujillo 2020

El presente proyecto de investigación que se realizó en la Universidad Privada del Norte de Trujillo, sede San Isidro, tuvo como finalidad estudiar la influencia de la adición de Ceniza de Cascarilla de Arroz (CCA) en las propiedades mecánicas del concreto, con el fin de obtener resultados positivos que ayuden a comprender la influencia de dicha puzolana artificial en el concreto y así lograr la optimización de costos. Para realizar dicha investigación se emplearon diferentes porcentajes de CCA (5%,10% y 15%) añadidos al concreto, los cuales fueron estudiados bajo una serie de ensayos estandarizados y normados, entre ellos están el ensayo de resistencia a la compresión (NTP 339.034), velocidad de succión capilar (IRAM 1871) y Profundidad de penetración de agua bajo presión (Norma UNE-EN 12390-8:2009). Los resultados finales del presente proyecto fueron que la utilización de la ceniza de cascarilla de arroz (CCA) mejora la resistencia a la Compresión del diseño al 15% (CCA) a la edad de 56 días en 320.11 kg/cm2 respecto al diseño patrón, además se encontró que la velocidad de succión capilar del diseño al 5%, 10% y 15% de CCA fue de 1.18 [g/(m².s½)], 1.05 [g/(m².s½)] y 0.96 [g/(m².s½)] respectivamente. También se encontró que los diseños de 5%, 10%, 15% de CCA no cumple con la profundidad media y profundidad máxima especificada en la norma EHE-08

Abating the Feminization of Poverty: Changing the Rules Governing Post - Decree Modification of Child Support Obligations

El crecimiento estimado para el mercado mundial de espacios de coworking será de 17% para el año 2020, respecto del año anterior (Desmag, 2018), lo cual muestra el dinamismo de esta nueva forma de trabajar a nivel mundial. En el 2013 se registró la primera empresa de coworking en el Perú denominada Comunal, luego ingresaron al mercado otras marcas internacionales y locales. El punto en común entre todas las opciones actuales es que sus modelos de negocios están enfocados en generar comodidad, modernidad y ahorro a sus arrendatarios.  El presente Plan de Negocios tiene como objetivo desarrollar una nueva propuesta de espacios compartidos, denominada Prime Coworking. Este espacio generará ahorro a emprendedores, pequeñas y medianas empresas, siguiendo las tendencias locales e internacionales. Esto se logrará ofreciendo ambientes cómodos, modernos e implementados para la actividad empresarial, y sobre todo que contribuyan a incentivar la retención de sus trabajadores mediante capacitaciones en habilidades blandas. Por último, con la evaluación del proyecto se concluye que el negocio es viable, dado que para una inversión total de 1 007 160 soles se genera un valor actual neto de 338 mil soles. La inversión será financiada con un aporte de los socios de 705 010 soles que generará un valor para el accionista de 311 000 soles, para un periodo de valoración de 5 años y con un payback de 3.6 años.Coworking spaces global market growth is estimated to be 17% YoY by 2020, (Desmag, 2018), which shows the increasing demand for this new way of working worldwide. In 2013, the first coworking company in Peru called Comunal was registered, then other international and local brands entered the local market. The common point among all market competitors is that their business models are focused on generating comfort, a trendy style and operating savings to their tenants. This Business Plan aims to develop a new proposal for shared spaces, called Prime Coworking, that follows local and international trends and generates savings to entrepreneurs, small and medium enterprises. It does this by offering comfortable, modern and fully implemented environments for doing business and especially by encouraging the engagement of their employees through training in soft skills. Lastly, after our project evaluation it is concluded that the business is profitable, given a total investment of 1 007 160 soles, and an NPV of 338 thousand soles. This investment will be financed with equity of 705 010 soles in shares that will generate a shareholder value of 311 000 soles, for a period of 5 years with a payback of 3.6 years.Trabajo de investigació

Study protocol for THINK : a multinational open-label phase I study to assess the safety and clinical activity of multiple administrations of NKR-2 in patients with different metastatic tumour types

Introduction: NKR-2 are autologous T cells genetically modified to express a chimeric antigen receptor (CAR) comprising a fusion of the natural killer group 2D (NKG2D) receptor with the CD3 zeta signalling domain, which associates with the adaptor molecule DNAX-activating protein of 10 kDa (DAP10) to provide co-stimulatory signal upon ligand binding. NKG2D binds eight different ligands expressed on the cell surface of many tumour cells and which are normally absent on non-neoplastic cells. In preclinical studies, NKR-2 demonstrated long-term antitumour activity towards a breadth of tumour indications, with maximum efficacy observed after multiple NKR-2 administrations. Importantly, NKR-2 targeted tumour cells and tumour neovasculature and the local tumour immunosuppressive microenvironment and this mechanism of action of NKR-2 was established in the absence of preconditioning. Methods and analysis: This open-label phase I study will assess the safety and clinical activity of NKR-2 treatment administered three times, with a 2-week interval between each administration in different tumour types. The study will contain two consecutive segments: a dose escalation phase followed by an expansion phase. The dose escalation study involves two arms, one in solid tumours (five specific indications) and one in haematological tumours (two specific indications) and will include three dose levels in each arm: 3x10(8), 1x10(9) and 3x10(9) NKR-2 per injection. On the identification of the recommended dose in the first segment, based on dose-limiting toxicity occurrences, the study will expand to seven different cohorts examining the seven different tumour types separately. Clinical responses will be determined according to standard Response Evaluation Criteria In Solid Tumors (RECIST) criteria for solid tumours or international working group response criteria in haematological tumours. Ethics approval and dissemination: Ethical approval has been obtained at all sites. Written informed consent will be taken from all participants. The results of this study will be disseminated through presentation at international scientific conferences and reported in peer-reviewed scientific journals

Improving efficiency of analysis jobs in CMS

Hundreds of physicists analyze data collected by the Compact Muon Solenoid (CMS) experiment at the Large Hadron Collider using the CMS Remote Analysis Builder and the CMS global pool to exploit the resources of the Worldwide LHC Computing Grid. Efficient use of such an extensive and expensive resource is crucial. At the same time, the CMS collaboration is committed to minimizing time to insight for every scientist, by pushing for fewer possible access restrictions to the full data sample and supports the free choice of applications to run on the computing resources. Supporting such variety of workflows while preserving efficient resource usage poses special challenges. In this paper we report on three complementary approaches adopted in CMS to improve the scheduling efficiency of user analysis jobs: automatic job splitting, automated run time estimates and automated site selection for jobs